Targeting of central peptide receptors via nasal ligand application to modulate food intake (A03)

• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology ; Biochemistry
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838

We aim to understand the mechanisms of intranasal drug-application strategies for the transfer of potential peptide drugs to the central nerve system. As in the hypothalamus, NPY, melanocortin 4 and ghrelin receptors are strongly expressed, we hypothesize that single or a combination of these peptides can be used for the modulation of food intake. Furthermore, we aim to learn more on nasal application in general, on possible routes of transport (e.g., axonal versus venous) and possibilities to direct and influence these routes by chemical modifications. We want to find out, which parts of the brain can be addressed by this pathway, and whether this is a suitable approach for peptides addressing brain areas. Finally, we aim to compare physiological effects of nasal, subcutaneous and central applications in suitable animal models.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1052: Obesity Mechanisms
• Applicant Institution: Universität Leipzig
• Project Heads: Professor Dr. Ingo Bechmann, since 7/2021; Professorin Dr. Annette G. Beck-Sickinger; Privatdozentin Dr. Nora Klöting-Blüher, until 6/2021; Dr. Angela Schulz, until 12/2016