Project Details
Projekt
Targeting disease-causing cells by DNA hypomethylation in juvenile myelomonocytic leukaemia (C05)
Subject Area
Hematology, Oncology
Term
from 2012 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 192904750
Juvenile myelomonocytic leukaemia (JMML) is a myeloproliferative disorder of early childhood and it is standard practice to prepare every patient for a haematopoietic stem cell transplant (HSCT) as the only curative therapy. However, the risk of relapse is high. We will characterise the early cellular effects of DNA hypomethylation in JMML leukaemia-initiating cells (LICs) by integrated DNA methylation profiling in our xenograft model, and will validate their clinical significance in primary patient material. Our ultimate goal is to identify mechanisms that help to overcome resistance of JMML LICs to azacitidine and HSCT.
DFG Programme
Collaborative Research Centres
Applicant Institution
Albert-Ludwigs-Universität Freiburg
Project Head
Professor Dr. Christian Flotho
