Epigenetic effects of NFE2 and JAK2V617F mutations in MPN (B02)

• Subject Area: Public Health, Healthcare Research, Social and Occupational Medicine
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 192904750

We have defined distinct classes of NFE2 mutations in patients with myeloproliferative neoplasms (MPN) and could demonstrate that elevated expression of the transcription factor NFE2 in MPN patients is regulated by epigenetic pathways. Now we will integrate changes in the transcriptome and histone modifications conferred by wt-NFE2 and the NFE2 mutations, to understand how NFE2 alters the epigenetic landscape to promote leukemic transformation. These data will allow us to discriminate between two alternative pathophysiological models of disease initiation and progression.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 992: Medical Epigenetics (MEDEP) - From Basic Mechanisms to Clinical Applications
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Heike L. Pahl