Histone methylation is a crucial epigenetic event, involved in many pathological processes. In collaboration with B01 we characterised two new lysine methyltransferases (KMTs), named KMT9 and KMT10. In the next funding period we propose to set up a comprehensive assay platform for KMT9 and KMT10 including assays for cellular target engagement. The proposed work will greatly advance the knowledge on KMT9 and KMT10 function in physiology and pathology and uncover their potential in drug development.
DFG Programme
Collaborative Research Centres
