The basic composition of mammalian heterochromatin (A01)

Deregulation of most heterochromatin core components has been linked to complex human disorders that display a strong epigenetic contribution. We will reconstruct heterochromatin by insertion of repeat elements into inert genomic regions. In addition, the transcriptional response of repeat-rich heterochromatin by epigenetic inhibition of chromatin-modifying enzymes will be investigated. Together, these approaches will provide new insights into the genome-wide profile and adaptability of mammalian heterochromatin, as it will be relevant for normal and perturbed development.

DFG Programme Collaborative Research Centres

Subproject of SFB 992:  Medical Epigenetics (MEDEP) - From Basic Mechanisms to Clinical Applications

Applicant Institution Albert-Ludwigs-Universität Freiburg

Co-Applicant Institution Max-Planck-Institut für Immunbiologie und Epigenetik

Project Head Professor Dr. Thomas Jenuwein