Stress dependent responses of mRNA 3´-end processing (05)

• Subject Area: Cell Biology
• Term: from 2012 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 201348542

The team of Andreas Kulozik and Matthias Hentze (TP05) found that stress induces alternative polyadenylation (APA) of mRNAs. The team will address the molecular mechanism and the physiological importance of this novel mode of stress-dependent gene regulation. Using global tools for the analysis, they aim at unraveling the key cis-acting sequences and trans-acting factors involved in ribotoxic, ER- and oxidative stress-induced APA.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1036: Cellular Surveillance and Damage Response
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Co-Applicant Institution: European Molecular Biology Laboratory (EMBL)
• Project Heads: Professor Dr. Matthias Hentze; Professor Andreas Eckhard Kulozik, Ph.D.