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The role of MAPK pathways in influenza virus replication and bacterial super-infection (B02)

Subject Area Virology
Term from 2012 to 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054
 
Influenza viruses are barrier breaking pathogens that exploit cellular pathways to promote their replication. We have identified the Raf/MEK/ERK MAPK pathway to play a crucial role in virus replication and showed that this dependency could be used for a novel anti-influenza approach using MEK inhibitors. In the new funding period, we will not only further study the role of the pathway in ERK-mediated vRNP nuclear export but also explore a newly identified contribution of immunomodulatory activity of MEK inhibitors to prevent virus and even super-infecting bacteria from breaking the immune barrier against infections.
DFG Programme Collaborative Research Centres
Applicant Institution Universität Münster
 
 

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