Antigen- and leukocyte-trafficking events guiding effective CD8+T lymphocyte differentiation (B04)

• Subject Area: Immunology
• Term: from 2011 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 165054336

"Time" and "location" are the defining parameters of leukocyte motility and migration. Systemic Listeria monocytogenes infection in mice provides a unique model to study leukocyte migration and interaction processes during the development of antibacterial immunity. We will use a combination of intravital imaging and ex vivo methods to study how leukocytes capture, handle and traffic bacteria within the splenic marginal zone. In addition, we will study how these events influence the induction of pathogen-specific T lymphocytes in the context of the overall developing antibacterial response.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease
• Applicant Institution: Ludwig-Maximilians-Universität München
• Co-Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Dirk Busch; Professor Admar Verschoor, Ph.D.