Stability and Violation of the Lymphoid and Myeloid Dichotomy in the Immune System (L)

• Subject Area: Immunology
• Term: from 2011 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 178696424

By combining fate mapping approaches and cell transplantations we could demonstrate that tissue macrophages in brain, skin, lung, liver, pancreas and spleen autonomous populations of embryonic or fetal origin. Despite being myeloid lineages, these tissue-resident cells can be distinguished from recruited bone marrow-derived macrophages by a lymphoid fate mapping mark. In the upcoming funding period we plan to expand our studies to identify the embryonic or fetal precursors of tissue macrophages, investigate the homeostasis of tissue macrophages in different organs and analyze the contributions and functions of tissue resident and recruited macrophages under challenge.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 938: Environment Specific Control of Immunological Reactivity
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Co-Applicant Institution: Deutsches Krebsforschungszentrum (DKFZ)
• Project Head: Professor Dr. Hans-Reimer Rodewald