Exogenous and endogenous ligands of Toll-like receptors (TLR) alter differentiation, maturation and function of myeloid and lymphoid cells. In part this is due to alterations in the micro RNA (miR) expression profiles of these cells. miRs are thereby not only indicators but also direct initiators of adaption or maintenance of cellular functional phenotypes. Based on two model systems (tolerogenic TLR-APC and IL-10-producing B cells) the interrelationship between exogenous signals (TLR), endogenous signaling, intracellular regulation (miR) and phenotypic function will be analyzed.
DFG Programme
Collaborative Research Centres
