Spatial modeling of gradient sensing exemplified for the yeast pheromone response (D08)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: from 2011 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 25065445

Yeast cells mate using pheromone secretion and sensing and directed protrusion formation. Employing a combination of fluorescence and atomic force microscopy with spatiotemporal mathematical modeling, we will investigate the role of functional modules in three types of processes: i) pattern formation of pheromones, ii) implementation of stable spatial cell response, and iii) induction and mechanics of cell shape change. On top, we study principles of mutual information exchange among the mating cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 740: From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Co-Applicant Institution: Humboldt-Universität zu Berlin
• Project Head: Professorin Dr. Edda Klipp