TRR 37:  Mikro- und Nanosysteme in der Medizin - Rekonstruktion biologischer Funktionen

• Fachliche Zuordnung: Medizin ; Biologie ; Materialwissenschaft und Werkstofftechnik
• Förderung: Förderung von 2007 bis 2012
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 18489454

• Erstellungsjahr: 2005

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Micro- and nanopatterned star poly(ethylene glycol) (PEG) materials prepared by UV-based imprint lithography. Langmuir. 23:7841- 6. 2007
  Lensen MC, Mela P, Mourran A, Groll J, Heuts J, Rong HT, Moller M
  (Siehe online unter https://doi.org/10.1021/la7007683)
• Effect of solvent isotopic replacement on the structure evolution of gold nanorods. J Phys Chem C. 112:13483-7. 2008
  Keul HA, Moeller M, Bockstaller MR
  (Siehe online unter https://doi.org/10.1021/jp803799k)
• Imidazolium-based ionic liquids as efficient shape-regulating solvents for the synthesis of gold nanorods. Angew Chem Int Ed Engl. 47:7639-43. 2008
  Ryu HJ, Sanchez L, Keul HA, Raj A, Bockstaller MR
  (Siehe online unter https://doi.org/10.1002/anie.200802185)
• Green laser light activates the inner ear. J Biomed Opt. 14. 2009
  Wenzel GI, Balster S, Zhang KY, Lim HH, Reich U, Massow O, Lubatschowski H, Ertmer W, Lenarz T, Reuter G
  (Siehe online unter https://doi.org/10.1117/1.3174389)
• Intracardiac injection of erythropoietin induces stem cell recruitment and improves cardiac functions in a rat myocardial infarction model. J Cell Mol Med. 13:664-79. 2009
  Klopsch C, Furlani D, Gabel R, Li WZ, Pittermann E, Ugurlucan M, Kundt G, Zingler C, Titze U, Wang WW, Ong LL, Wagner K, Li RK, Ma N, Steinhoff G
  (Siehe online unter https://doi.org/10.1111/j.1582-4934.2008.00546.x)
• Nanomolding of PEG-based hydrogels with sub-10-nm resolution. Small. 5:2756-60. 2009
  Diez M, Mela P, Seshan V, Moller M, Lensen MC
  (Siehe online unter https://doi.org/10.1002/smll.200901313)
• Optoacoustic induced vibrations within the inner ear. Opt Express.17:23037-43. 2009
  Zhang KY, Wenzel GI, Balster S, Lim HH, Lubatschowski H, Lenarz T, Ertmer W, Reuter G
  (Siehe online unter https://doi.org/10.1364/oe.17.023037)
• Repetition rate dependency of reactive oxygen species formation during femtosecond laser-based cell surgery. J Biomed Opt. 14. 2009
  Baumgart J, Kuetemeyer K, Bintig W, Ngezahayo A, Ertmer W, Lubatschowski H, Heisterkamp A
  (Siehe online unter https://doi.org/10.1117/1.3253382)
• Synthesis, characterization, and visualization of highmolecular-weight poly(glycidol-graft-ϵ-caprolactone) starlike polymers. Macromolecules. 42:1031-6. 2009
  Hans M, Mourran A, Henke A, Keul H, Moeller M
  (Siehe online unter https://doi.org/10.1021/ma802391s)
• Three-Dimensional Biodegradable Structures Fabricated by Two-Photon Polymerization. Langmuir.25:3219-23. 2009
  Claeyssens F, Hasan EA, Gaidukeviciute A, Achilleos DS, Ranella A, Reinhardt C, Ovsianikov A, Xiao S, Fotakis C, Vamvakaki M, Chichkov BN, Farsari M
  (Siehe online unter https://doi.org/10.1021/la803803m)
• Biocompatibility of nanoactuators: stem cell growth on laser-generated nickel-titanium shape memory alloy nanoparticles. J Nanopart Res. 12:1733-42. 2010
  Barcikowski S, Hahn A, Guggenheim M, Reimers K, Ostendorf A
  (Siehe online unter https://doi.org/10.1007/s11051-009-9834-4)
• Circulating angiopoietins in idiopathic pulmonary arterial hypertension. Eur Heart J. 31:2291-300. 2010
  Kumpers P, Nickel N, Lukasz A, Golpon H, Westerkamp V, Olsson KM, Jonigk D, Maegel L, Bockmeyer CL, David S, Hoeper MM
  (Siehe online unter https://doi.org/10.1093/eurheartj/ehq226)
• Fs-laser-induced Ca2+ concentration change during membrane perforation for cell transfection. Opt Express.18:2219-29. 2010
  Baumgart J, Bintig W, Ngezahayo A, Lubatschowski H, Heisterkamp A
  (Siehe online unter https://doi.org/10.1364/oe.18.002219)
• Functionalization of Linear and Star-shaped Polyglycidols with Vinyl Sulfonate Groups and Their Reactions with Different Amines and Alcohols. Macromolecules.43:6295-301. 2010
  Haamann D, Keul H, Klee D, Moeller M
  (Siehe online unter https://doi.org/10.1021/ma100901q)
• Localized SDF-1alpha gene release mediated by collagen substrate induces CD117 stem cells homing. J Cell Mol Med.14:392-402. 2010
  Wang W, Li W, Ong LL, Furlani D, Kaminski A, Liebold A, Lutzow K, Lendlein A, Wang J, Li RK, Steinhoff G, Ma N
  (Siehe online unter https://doi.org/10.1111/j.1582-4934.2008.00624.x)
• Photoreactive Biodegradable Electrospun Fibers. Eur Cell Mater. 20:162. 2010
  Loesel R, Moeller M, Klee D
  
• Synthesis, characterization and in vitro degradation of 3D-microstructured poly(epsilon-caprolactone) resins. Polym Chem-Uk.1:1215-25. 2010
  Theiler S, Teske M, Keul H, Sternberg K, Moller M
  (Siehe online unter https://doi.org/10.1039/C0PY00097C)
• Thermoresponsive polyacrylates obtained via a cascade of enzymatic transacylation and FRP or NMP. Polym Chem-Uk.1:878-90. 2010
  Popescu D, Hoogenboom R, Keul H, Moeller M
  (Siehe online unter https://doi.org/10.1039/C0PY00051E)
• An advanced cone-and-plate reactor for the in vitro-application of shear stress on adherent cells. Clin Hemorheol Micro. 49:391-7. 2011
  Dreyer L, Krolitzki B, Autschbach R, Vogt P, Welte T, Ngezahayo A, Glasmacher B
  (Siehe online unter https://doi.org/10.3233/ch-2011-1488)
• Cell Origin of Human Mesenchymal Stem Cells Determines a Different Healing Performance in Cardiac Regeneration. PloS one. 6. 2011
  Gaebel R, Furlani D, Sorg H, Polchow B, Frank J, Bieback K, Wang WW, Klopsch C, Ong LL, Li WZ, Ma N, Steinhoff G
  (Siehe online unter https://doi.org/10.1371/journal.pone.0015652)
• Corneal Alterations during Combined Therapy with Cyclodextrin/Allopregnanolone and Miglustat in a Knock-Out Mouse Model of NPC1 Disease. PloS one. 6. 2011
  Hovakimyan M, Petersen J, Maass F, Reichard M, Witt M, Lukas J, Stachs O, Guthoff R, Rolfs A, Wree A
  (Siehe online unter https://doi.org/10.1371/journal.pone.0028418)
• Electrochemistry-controlled metal ion release from silicone elastomer nanocomposites through combination of different metal nanoparticles. J Mater Chem. 21:10287-9. 2011
  Hahn A, Gunther S, Wagener P, Barcikowski S
  (Siehe online unter https://doi.org/10.1039/C0JM04480F)
• Highly efficient 3D fluorescence microscopy with a scanning laser optical tomograph. Opt Express. 19:5419- 30. 2011
  Lorbeer RA, Heidrich M, Lorbeer C, Ramirez Ojeda DF, Bicker G, Meyer H, Heisterkamp A
  (Siehe online unter https://doi.org/10.1364/oe.19.005419)
• Intracardiac injection of matrigel induces stem cell recruitment and improves cardiac functions in a rat myocardial infarction model. J Cell Mol Med.15:1310-8. 2011
  Ou LL, Li WZ, Zhang Y, Wang WW, Liu J, Sorg H, Furlani D, Gaebel R, Mark P, Klopsch C, Wang L, Lutzow K, Lendlein A, Wagner K, Klee D, Liebold A, Li RK, Kong DL, Steinhoff G, Ma N
  (Siehe online unter https://doi.org/10.1111/j.1582-4934.2010.01086.x)
• Laser Printing of Stem Cells for Biofabrication of Scaffold-Free Autologous Grafts. Tissue Eng Part C-Me.17:79-87. 2011
  Gruene M, Deiwick A, Koch L, Schlie S, Unger C, Hofmann N, Bernemann I, Glasmacher B, Chichkov B
  (Siehe online unter https://doi.org/10.1089/ten.tec.2010.0359)
• Magnetic targeting strategies in gene delivery. Nanomedicine (Lond).6:1593-604. 2011
  Delyagina E, Li W, Ma N, Steinhoff G
  (Siehe online unter https://doi.org/10.2217/nnm.11.143)
• Metal ion release kinetics from nanoparticle silicone composites. J Control Release. 154:164-70. 2011
  Hahn A, Brandes G, Wagener P, Barcikowski S
  (Siehe online unter https://doi.org/10.1016/j.jconrel.2011.05.023)
• Osteopontin in patients with idiopathic pulmonary hypertension. Chest. 139:1010-7. 2011
  Lorenzen JM, Nickel N, Kramer R, Golpon H, Westerkamp V, Olsson KM, Haller H, Hoeper MM
  (Siehe online unter https://doi.org/10.1378/chest.10-1146)
• Patterning human stem cells and endothelial cells with laser printing for cardiac regeneration. Biomaterials. 32:9218-30. 2011
  Gaebel R, Ma N, Liu J, Guan J, Koch L, Klopsch C, Gruene M, Toelk A, Wang W, Mark P, Wang F, Chichkov B, Li W, Steinhoff G
  (Siehe online unter https://doi.org/10.1016/j.biomaterials.2011.08.071)
• Plexiform lesions in pulmonary arterial hypertension composition, architecture, and microenvironment. Am J Pathol.179:167-79. 2011
  Jonigk D, Golpon H, Bockmeyer CL, Maegel L, Hoeper MM, Gottlieb J, Nickel N, Hussein K, Maus U, Lehmann U, Janciauskiene S, Welte T, Haverich A, Rische J, Kreipe H, Laenger F
  (Siehe online unter https://doi.org/10.1016/j.ajpath.2011.03.040)
• Polyethylenimine-mediated gene delivery into human bone marrow mesenchymal stem cells from patients. J Cell Mol Med. 15:1989-98. 2011
  Wang W, Li W, Ou L, Flick E, Mark P, Nesselmann C, Lux CA, Gatzen HH, Kaminski A, Liebold A, Lutzow K, Lendlein A, Li RK, Steinhoff G, Ma N
  (Siehe online unter https://doi.org/10.1111/j.1582-4934.2010.01130.x)
• Synthesis and characterization of biodegradable polyester/polyether resins via Michael-type addition. Polym Chem-Uk. 2:2273-83. 2011
  Theiler S, Diamantouros SE, Jockenhoevel S, Keul H, Moeller M
  (Siehe online unter https://doi.org/10.1039/C1PY00262G)
• Three-dimensional laser micro- and nano-structuring of acrylated poly(ethylene glycol) materials and evaluation of their cytoxicity for tissue engineering applications. Acta biomaterialia.7:967-74. 2011
  Ovsianikov A, Malinauskas M, Schlie S, Chichkov B, Gittard S, Narayan R, Lobler M, Sternberg K, Schmitz KP, Haverich A
  (Siehe online unter https://doi.org/10.1016/j.actbio.2010.10.023)
• Authentication of primordial characteristics of the CLBL-1 cell line prove the integrity of a canine B-cell lymphoma in a murine in vivo model. PloS one. 7:e40078. 2012
  Rutgen BC, Willenbrock S, Reimann-Berg N, Walter I, Fuchs-Baumgartinger A, Wagner S, Kovacic B, Essler SE, Schwendenwein I, Nolte I, Saalmuller A, Murua Escobar H
  (Siehe online unter https://doi.org/10.1371/journal.pone.0040078)
• Confocal Laser Scanning Microscopy, a New In Vivo Diagnostic Tool for Schistosomiasis. PloS one. 7. 2012
  Fritzsche C, Stachs O, Holtfreter MC, Nohr-Luczak C, Guthoff RF, Reisinger EC
  (Siehe online unter https://doi.org/10.1371/journal.pone.0034869)
• Cytotoxicity and ion release of alloy nanoparticles. J Nanopart Res. 14. 2012
  Hahn A, Fuhlrott J, Loos A, Barcikowski S
  (Siehe online unter https://doi.org/10.1007/s11051-011-0686-3)
• DE 10 2007 004 906A1, dazu auch WO002008090225A1 und US 2009/0326432 A1. Augenimplantat. 2007. US000008206333B2
  Schmidt W, Sternberg K, Behrend D, Guthoff R and Schmitz KP
  
• Development of a micro-mechanical valve in a novel glaucoma implant. Biomedical microdevices. 2012
  Siewert S, Schultze C, Schmidt W, Hinze U, Chichkov B, Wree A, Sternberg K, Allemann R, Guthoff R, Schmitz KP
  (Siehe online unter https://doi.org/10.1007/s10544-012-9670-7)
• Erythropoietin attenuates the sequels of ischaemic spinal cord injury with enhanced recruitment of CD34(+) cells in mice. J Cell Mol Med. 16:1792-802. 2012
  Hirano K, Wagner K, Mark P, Pittermann E, Gabel R, Furlani D, Li W, Vollmar B, Yamada T, Steinhoff G, Ma N
  (Siehe online unter https://doi.org/10.1111/j.1582-4934.2011.01489.x)
• Everolimus in Combination with Cyclosporin A as Pre- and Posttransplantation Immunosuppressive Therapy in Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Tr. 18:1061-8. 2012
  Junghanss C, Rathsack S, Wacke R, Weirich V, Vogel H, Drewelow B, Mueller S, Altmann S, Freund M, Lange S
  (Siehe online unter https://doi.org/10.1016/j.bbmt.2011.12.522)
• Plexiform vasculopathy of severe pulmonary arterial hypertension and microRNA expression. J Heart Lung Transpl. 31:764-72. 2012
  Bockmeyer CL, Maegel L, Janciauskiene S, Rische J, Lehmann U, Maus UA, Nickel N, Haverich A, Hoeper MM, Golpon HA, Kreipe H, Laenger F, Jonigk D
  (Siehe online unter https://doi.org/10.1016/j.healun.2012.03.010)