Charakterisisierung und Modulation der Inflammationsreaktion nach hämorrhagischem Schock in der chronischen alkoholinduzierten Fettleber

• Antragsteller: Professor Dr. Mark Lehnert
• Fachliche Zuordnung: Orthopädie, Unfallchirurgie, rekonstruktive Chirurgie
• Förderung: Förderung von 2010 bis 2013
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 164568778

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2005) Hemorrhage/resuscitation induced liver injury in the rat can be reduced by a peptide inhibitor of c-Jun N-terminal kinase. 9th Annual Meeting on Surgical Research/9. Chirurgische Forschungstage, Frankfurt, Posterpreis der dt. Gesellschaft für Chirurgie, Langenbeck's Archive of Surgery, Vol. 390, pp.1435-2443
  Lee V.S.Y, Lehnert M, Henrich D, Czerny C, Borsello T, Marzi I
  
• (2006). A peptide inhibitor of c-Jun N-terminal kinase applied after hemorrhagic shock reduces liver damage in rats. 10th Annual Meeting on Surgical Research/10. Chirurgische Forschungstage, Münster, Langenbeck's Archieves of Surgery, Vol. 391, pp.441-544
  Relja B, Henrich D, Czerny C, Borsello T, Lehnert M, Marzi I
  
• (2006). c-JUN NH2-terminal kinase mediates the hepatic stress response after rat hemorrhage/resuscitation. Twelfth Congress of the European Shock Society, Ulm, Germany. Shock, Vol. 26, Sup. 1, pp.1-41
  Relja B, Schwestka B, Sun-Young Lee V, Henrich D, Czerny C, Borsello T, Lehnert M, Marzi I
  
• (2007). Der HMG-CoA Reduktasehemmer Simvastatin reduziert den Leberschaden und die systemische Inflammation nach hämorrhagischem Schock bei Ratten. 11th Annual Meeting on Surgical Research/11. Chirurgische Forschungstage, Saarbrücken, Germany. Langenbeck's Archieves of Surgery, Vol. 392, pp.1435-2451
  Seyboth K, Relja B, Henrich D, Lehnert M, Marzi I
  
• (2007). Inhibition of c-JUN Nterminal kinase after hemorrhage but before resuscitation reduces liver damage, hepatic and systemic inflammation in rats. 7th World Congress on Trauma, Shock, Inflammation and Sepsis, Munich, Inflammation Research, Vol 56, Sup. 2, S93
  Lehnert M, Relja B, Henrich D, Borsello T Marzi I
  
• (2008). Binge like ethanol exposure augments the hemorrhage/resuscitation induced liver injury and the proinflammatory response in rats - effects of simvastatin pre-treatment. 6th Congress of the International Federation of Shock Societies & 31st Annual Conference on Shock, Cologne, Germany. Shock, Vol. 29(7), Sup. 1, pp.1-120
  Bormann F, Relja B, Höhn C, Henrich D, Czerny C, Lehnert M, Marzi I
  
• (2008). Hemorrhage/resuscitation induced mortality in rats is decreased both after binge ethanol consumption and simvastatin pretreatment whereas early proinflammatory changes become differentially activated. 6th Congress of the International Federation of Shock Societies & 31st Annual Conference on Shock, Cologne, Germany. Shock, Vol. 29(7), Sup. 1, pp.1-120
  Höhn C, Relja B, Bormann F, Henrich D, Czerny C, Lehnert M, Marzi I
  
• (2008). Increased susceptibility to liver injury after hemorrhage/resuscitation in rats acutely fed ethanol - role of pre-treatment with plant polyphenols. 6th Congress of the International Federation of Shock Societies & 31st Annual Conference on Shock, Cologne, Germany. Shock, Vol. 29(7), Sup. 1, pp.1-120
  Toettel E, Breig L, Relja B, Henrich D, Czerny C, Schneider H, Lehnert M, Marzi I
  
• (2008). Simvastatin dependent expression of heme oxygenase-1 prevents liver injury after hemorrhage/resuscitation in rats. 12th Annual Meeting on Surgical Research/12. Chirurgische Forschungstage: Chirurgische Forschung - Brückenschlag zwischen Klinik, Forschung und Industrie, Freiburg i. Breisgau, Germany. Langenbeck's Archieves of Surgery, Vol. 393, pp.1435-2443
  Relja B, Lehnert M, Seyboth K, Bormann F, Czerny C, Henrich D, Marzi I
  
• A peptide inhibitor of C-jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Shock 2008; 30(2):159-65
  Lehnert M, Relja B, Sun-Young Lee V, Schwestka B, Henrich D, Czerny C, Froh M, Borsello T, Marzi I
  
• (2009). Akute Alkoholbelastung verbessert das Überleben nach hämorrhagischem Schock und nachfolgender Reperfusion bei weiblichen Lewis-Ratten. Deutscher Kongress für Orthopädie und Unfallchirurgie, Berlin
  Lehnert M, Relja B, Riedl N, Czerny C, Henrich D, Marzi I
  
• Inhibition of c-JUN N-terminal kinase after hemorrhage but before resuscitation mitigates hepatic damage and the inflammatory response in rats. Shock
  Relja B, Schwestka B, Lee VSY, Henrich D, Czerny C, Borsello T, Marzi I, Lehnert M
  
• Simvastatin dependent ROCK modulation reduces mortality and hepatic injury after hemorrhage/resuscitation in rats
  Relja B, Lehnert M, Seyboth K, Bormann F, Höhn C, Czerny C, Henrich D, Marzi I