This project will use conventional and inducible KO mice for Neuroplastin and plasma membrane Ca2+ ATPases to characterize the impact of disturbed Ca2+ clearance on T cell signaling and assess possible Ca2+-independent roles of Neuroplastin (collaborations with A04, A29N, B19 and Z01). Supported by projects B14 and A25, Nptn -/- T cells will be challenged in in vivo models for selected aspects of immune activation.
DFG Programme
Collaborative Research Centres