Plasticity and cell type-specific function of OTUB1 in infection (A05)

• Subject Area: Immunology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925

A05 defined that the deubiquitinating enzyme (DUB) CYLD aggravates listeriosis by inhibiting protective signaling pathways, whereas the DUB A20 ameliorates listeriosis by enabling the survival of CD8+ memory T cells. Employing a newly established conditional OTUB1-/- mouse strain, A05 identified that the DUB OTUB1 regulates JAK-, TLR11- and YB-1-mediated signaling. In the next funding period, A05 will focus on OTUB1 in (1) T cells, (2) DCs, (3) macrophages and (4) hepatocytes in listeriosis to determine the cell type-specific molecular function (cooperation with B19, B26) and plasticity (cooperation with A01, A04, A30N, Z01) of OTUB1 under inflammatory conditions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 854: Molecular Organisation of Cellular Communications within the Immune System
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professor Dr. Michael Naumann; Professor Dr. Dirk Schlüter