Influence of cold shock Y-box (YB) protein-1 on monocytic cell activation and inflammatory kidney diseases (A01)

• Subject Area: Nephrology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925

Cold shock proteins fulfill cell-specific tasks in inflammatory diseases. In YB-1 whole body knockout animals the inflammatory response is ablated and fibrosis reduced when experimental kidney diseases are induced. With cell-specific depletion of YB-1 in monocytes/granulocytes/macrophages the inflammatory cell recruitment is enhanced. The project addresses at the molecular level, how YB-1 affects the monocytic cell phenotype, which functions extracellular YB-1 executes and how the expression of the cold shock protein is regulated in circulating immune cells in inflammatory diseases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 854: Molecular Organisation of Cellular Communications within the Immune System
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Head: Professor Dr. Peter Rene Mertens