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Professorin Dr. Katharina Zarnack

Address Julius-Maximilians-Universität Würzburg
Biozentrum der Universität Würzburg
Lehrstuhl für Bioinformatik
Am Hubland
97074 Würzburg

Projects

As Applicant
- Current projects
  - Alternative splicing of CD19 mRNA in pediatric leukemia and CART-19 therapy resistance - Regulators, genetic variants and cryptic isoforms (Research Grants)
  - A joint experimental and computational approach to study the functions of the RNA-binding protein PURA and its role in the neurodevelopmental disease PURA Syndrome (Research Grants)
- Completed projects
  - Deciphering the molecular code of protein-RNA binding during mRNA localisation (Research Units)
  - Combination of transcriptome-wide and structural approaches to study SHE binding to RNA localization elements in budding yeast (Research Units)
  - Mechanistic and functional characterization of Makorin 1 mRNPs (Priority Programmes)
As Project Head
- Current projects
  - Sources and consequences of intrinsic genomic instability across human cell types (Collaborative Research Centres)
  - The role of arcRNAs and nuclear condensate dynamics in the splicing response to hypoxia (CRC/Transregios)
- Completed projects
  - Dissecting the regulatory mechanisms of alternative polyadenylation and nuclear retention of mRNAs by SR proteins (Collaborative Research Centres)
  - Elucidating protein-RNA interactions in circRNA biogenesis and function (CRC/Transregios)
As Cooperation Partner
- Completed projects
  - mRNP assembly at the 3' splice site studied by functional genomics and structural biology (Priority Programmes)

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