Project Details

Professor Dr. Mark Helm

Address Johannes Gutenberg-Universität Mainz
Institut für Pharmazeutische und Biomedizinische Wissenschaften
Staudinger Weg 5
55128 Mainz

Projects

As Applicant
- Current projects
  - Dihydrouridine RNA modification marks: written and erased by the same enzyme (Research Grants)
- Completed projects
  - Das Versagen molekularer Qualitätsstempel in mitochondrialen Myopathien: Modifikationsenzyme überwachen Strukturbildung und Steady-State Level von mitochondrialer tRNA Ser(UCN) (Research Grants)
  - Modulation von Strukturdynamik und post-transkritionellen Modifikationen in mitochondrialen Ribonukleinsäuren durch pathogene Mutationen (Research Grants)
  - RNA-Substrate Sepcificity of Dnmt2 (Research Units)
  - High-throughput technology for detection of RNA modifications (Research Grants)
  - Immune-modulating nucleotide modifications within tRNA (Research Grants)
  - The epitranscriptome in Drosophila melanogaster (Research Grants)
  - Detection and Identification of new RNA modifications (Priority Programmes)
  - Coordination Funds (Priority Programmes)
  - Identification and characterization of RNA modifications with immune-modulatory properties acting on Toll-like receptors (Priority Programmes)
As Leader
- Completed projects
  - Massenspektrometer mit Hochleistungs-Flüssigchromatographie (HPLC-MS) (Major Research Instrumentation)
  - Triple-quadrupol mass spectrometer (LC-MS) (Major Research Instrumentation)
As Spokesperson
- Current projects
  - TRR 319: RMaP: RNA Modification and Processing (CRC/Transregios)
- Completed projects
  - SPP 1784: Chemical Biology of native Nucleic Acid Modifications (Priority Programmes)
As Project Head
- Current projects
  - Modulation of the tumor microenvironment by addressing inhibitory (immune) cells via time-programmed and self-regulating liposome (Collaborative Research Centres)
  - Dynamics of modifications and processing of RNAs in the flavivirus replication cycle (CRC/Transregios)
  - Novel modification mapping techniques and efficient RNA-Seq data management (CRC/Transregios)
  - C03 Mass spectrometry of RNA and proteins in modified RNPs (CRC/Transregios)
  - Central Task of the Collaborative Research Center (CRC/Transregios)
- Completed projects
  - RNA-loaded functionalized nanoparticles for inhibition of tumour-associated regulatory T cells and antigen loading of human dendritic cells (Collaborative Research Centres)
  - Liposomes and polymersomes with multifunctional endgroups: targeting and controlled release (Collaborative Research Centres)

Servicenavigation

Hauptnavigation

Professor Dr. Mark Helm

Additional Information

Servicenavigation

Hauptnavigation

Professor Dr. Mark Helm

Additional Information

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