Professor Dr. Christian Freund

Address Freie Universität Berlin
Institut für Chemie und Biochemie
Arbeitsgruppe Proteinbiochemie
Thielallee 63
14195 Berlin

Projects

As Applicant
- Current projects
  - Mechanism and in vitro reconstitution of tapasin-mediated peptide exchange (Research Grants)
- Completed projects
  - Struktur-Funktionsanalyse der GYF-Domäne (Research Grants)
  - GYF-Domänen-vermittelte Protein-Wechselwirkungen (Research Grants)
  - Regulatorische Tyrosin-Phosphorylierungen von Vav und ADAP bei der T-Zell-Rezeptor-vermittelten Integrinadhäsion (Research Grants)
  - GYF domain mediated protein: protein interactions (Research Units)
  - Mechanismus des durch HLA-DM und kleine Moleküle vermittelten MHCII:Peptid-Austausch (Research Grants)
  - Establishing strategies for sortase-catalyzed multi-peptide assemblies to profile T-cell selectivity (Priority Programmes)
  - Dynamic properties of MHC class II allotypes (Research Grants)
As Leader
- Completed projects
  - 700 MHz NMR Spektrometer (Major Research Instrumentation)
  - High resolution hybrid mass spectrometer (Major Research Instrumentation)
  - MALDI-TOF/TOF mass spectrometer (Major Research Instrumentation)
As Spokesperson
- Current projects
  - TRR 186: Molecular Switches: Spatio-temporal Control of Cellular Signal Transmission (CRC/Transregios)
- Completed projects
  - FOR 806: Interfering with Intracellular Protein-protein Interactions - Probing Protein Functions with Small Molecules (Research Units)
As Project Head
- Current projects
  - The palmitoylation switch in activated T cells (CRC/Transregios)
  - Switching antigens by the exchange catalyst HLA-DM (CRC/Transregios)
  - Central Coordination (CRC/Transregios)
- Completed projects
  - Regulatory phosphorylation of scaffolding proteins of the inside-out-signaling complex (Collaborative Research Centres)
  - Multivalent interactions of WW and SH2 domains containing proteins (Collaborative Research Centres)
  - Core service facilities for the SFB 765: NMR spectroscopy, surface plasmon resonance, quartz crystal microbalance, calorimetry, and mass spectrometry (Collaborative Research Centres)
  - Systematic characterization of phosphoinositide switches involved in T cell function (CRC/Transregios)
  - ADAPtive T cell migration into the stressed brain (Collaborative Research Centres)
  - Regulation of SH3 domain-based scaffolds in clathrin-mediated endocytosis (Collaborative Research Centres)
  - Proteomics platform for protein interaction mapping (Collaborative Research Centres)
As Participating Person
- Completed projects
  - Administration and central services (Research Units)