Professor Dr. Volker Dötsch

Address Goethe-Universität Frankfurt am Main
Institut für Biophysikalische Chemie
Max-von Laue-Straße 9
60438 Frankfurt am Main

Projects

As Applicant
- Current projects
  - Characterization of the p63/p73 hetero-tetramer using selective DARPins (Research Grants)
  - Characterization of the function of iASPP as a scaffolding protein for selected proteins involved in inflammation (Research Grants)
  - Mechanisms of surveillance and repair of retrotransposon-mediated DNA damage in arrested and aging oocytes (Research Grants)
- Completed projects
  - Analyse der molekularen Dynamik der Nukleotid-bindenden Domäne des ABC-Transporters HlyB mittels NMR (Research Grants)
  - Structural and functional characterization of the oligomerization - and c-terminal domains from members of the p53 protein family (Research Grants)
  - Structural, biochemical and genetic analysis of the newly discovered Apaf-1-binding protein CABY (Research Grants)
  - Untersuchung der Wechselwirkung von PCP Domänen mit Interaktionspartnern in Nicht-ribosomalen Peptidsynthetasen (Research Grants)
  - Strukturbestimmung von Proteorhodopsin mittels NMR Spektroskopie (Research Grants)
  - Investigation of structure and function of p63 in the quality control of oocytes (Reinhart Koselleck Projects)
  - Characterization of the interaction of Get3 with the membrane bound receptors Get1 and Get2 (Research Grants)
  - Structure determination of the membrane bound protease LspA by NMR spectroscopy (Research Grants)
  - Investigation of the interaction of p63 with p300 and iASPP in oocytes. (Research Grants)
  - Investigation of TAp63a with conformation-selective DARPins (Research Grants)
  - Investigation of mixed ubiquitin chains and chain conformations (Research Grants)
  - Structure determination of the closed dimeric conformation of TAp63α and investigation of its CK1 dependent activation (Research Grants)
  - Investigation of the disease mechanism causing Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome and Ectrodactyly-ectodermal dysplasia-clefting syndrome (Research Grants)
As Spokesperson
- Completed projects
  - EXC 115: Macromolecular Complexes (Clusters of Excellence)
As Project Head
- Current projects
  - Bacterial evasion of selective autophagy pathways (Collaborative Research Centres)
  - Integrated Research Training Group (IRTG) (Collaborative Research Centres)
- Completed projects
  - Strukturelle und funktionelle Analyse integraler Membranproteine (Collaborative Research Centres)
  - Structural and Functional Investigation of Membrane Proteins by Combined Approaches of Cell-Free Expression and NMR Spectroscopy (Collaborative Research Centres)
  - Cell-free synthesized G-protein coupled receptors in synthetic membranes and other hydrophobic environments (Collaborative Research Centres)
  - Structural characterization of domain-domain interactions in autophagy (Collaborative Research Centres)
As Participating Person
- Completed projects
  - Solid-state NMR Spectroscopy on Biomolecular Complexes at Lowest Temperatures and Highest Fields (Research Grants)
  - Charakterisierung der molekularen Protein-Interaktion zwischen dem SIAH1 und dem AF4 Protein durch NMR-Strukturaufklärung (Research Grants)
  - Structural and functional analysis of the human endothelin receptor system (Research Grants)
  - Molecular analysis of signal transduction mechanisms in the Rcs regulation (Research Grants)
As Cooperation Partner
- Completed projects
  - Determinants for regulation of precursor protein fate (Research Grants)
As Co-Investigator
- Current projects
  - Cryo-electron microscopy structures and functional analysis of cell-free synthesized G-protein coupled receptors in complex with their cognate G-proteins and cotranslationally inserted into nanodiscs. (Research Grants)
- Completed projects
  - Customizing cell-free labelling strategies for the NMR analysis of membrane proteins (Research Grants)