Professor Dr. Björn Schumacher

Address Universitätsklinikum Köln
CECAD Forschungszentrum
Institute for Genome Stability in Ageing and Disease
Joseph-Stelzmann-Straße 26
50931 Köln

Projects

As Applicant
- Current projects
  - Investigation of the molecular mechanisms of premature lung aging and enhanced susceptibility for chronic lung diseases in a postnatal stress model (Research Grants)
  - Coordination Funds (Research Units)
  - Mechanical-stress induced DNA damage and genome mechanoprotection in cellular and organismal homeostasis (Research Units)
  - Epigenetic regulation of the cellular homeostasis amid transcription-blocking DNA damage during development and aging (Research Units)
  - Sex-specific contributions to genetic inheritance (Reinhart Koselleck Projects)
  - Age-related neurodegeneration: From DNA damage to proteostasis loss, shifting the paradigm (Research Grants)
  - Molecular physio-pathological mechanisms of Mediatorpathies associated to transcription-coupled repair (Research Grants)
  - Mechanisms of surveillance and repair of retrotransposon-mediated DNA damage in arrested and aging oocytes (Research Grants)
- Completed projects
  - Characterization of graphene immune-impacts through omics approaches and genotoxic analysis (Research Grants)
  - Targeting transcription-coupled DNA damage responses in CLL (Clinical Research Units)
  - DNA damage response pathways in podocytes: novel targets to treat focal segmental glomerulosclerosis (Clinical Research Units)
  - Mutation analysis of somatic signalling modifiers of the DNA damage response in germ cells (Research Grants)
  - Hereditary Consequences of Small RNAs (Research Grants)
  - Somatic regulation of germ cell apoptosis (Research Grants)
As Spokesperson
- Current projects
  - FOR 5504: Physiological causes and consequences of genome instability (Research Units)
As Participating Researcher
- Current projects
  - EXC 2030: CECAD - Excellent in Aging Research (Clusters of Excellence (ExStra))
- Completed projects
  - EXC 229: Cellular Stress Responses in Aging-Associated Diseases (Clusters of Excellence)
  - GRK 2407: Inflammatory and cellular stress signaling: Switches to vascular dysfunction (Research Training Groups)
As Project Head
- Current projects
  - The role of limbal stem cells in corneal (lymph)angiogenesis, inflammation and UV-induced pterygium pathogenesis (Collaborative Research Centres)
  - The role of chromatin structure regulation in the susceptibility to transcription-blocking lesions (Collaborative Research Centres)
  - Integrated Research Training Group (Collaborative Research Centres)
- Completed projects
  - Mechanisms of innate immune responses to DNA damage (Collaborative Research Centres)
  - KFO 286: Exploiting Defects in the DNA Damage Response for the Treatment of Chronic Lymphocytic Leukemia (Clinical Research Units)
  - UV-induced DNA damage in photoaging and skin homeostasis (Collaborative Research Centres)
As Co-Investigator
- Current projects
  - The role of ABCB5-expressing limbal epithelial stem cells in corneal lymphangiogenic privilege and pterygium pathogenesis (Research Units)