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Professor Dr. Reinhard Büttner

Address Uniklinik Köln
Institut für Pathologie
Kerpener Straße 62
50937 Köln

Projects

As Applicant
- Completed projects
  - Regulation von Differnzierung und programmierten Zelltod neuraler und neuroektodermaler Systeme durch den Transkriptionsfaktor AP-2 (Research Grants)
  - Genetische Mechanismen der Invasion und Metastasierung von Kolonkarzinomen (Research Grants)
  - Funktion des Gens der autosomal-rezessiven polyzystischen Nierenerkrankung (ARPKD) in der Organogenese (Research Grants)
  - Funktionelle Charakterisierung des Transkriptionsfaktors AP-2 delta (Research Grants)
  - Central diagnostics, genomics and biobanking (Clinical Research Units)
As Participating Researcher
- Completed projects
  - GRK 804: Analysis of Cellular Functions by Combinatorial Chemistry and Biochemistry (Research Training Groups)
As Project Head
- Current projects
  - Proteogenomic characterization of mantle cell lymphoma (Collaborative Research Centres)
  - Multiparametric analysis of lymphoma cells and their microenvironment (Collaborative Research Centres)
  - Predicting therapy response and relapse of aggressive B cell lymphomas (Collaborative Research Centres)
  - Predicting molecular mechanisms of adaptation to radio-chemotherapy in cancer (Collaborative Research Centres)
  - Translational Pathology Core (Collaborative Research Centres)
- Completed projects
  - The impact of the LIM domain proteins FHL2 and CRP2 on hepatic stellate cell activation and its crosstalk with TGF-beta signalling pathways in hepatic fibrogenesis (CRC/Transregios)
  - Oncogenic signaling pathways regulating invasive growth, metastasis and tumor microenvironment of small cell lung cancer (SCLC) (Collaborative Research Centres)
  - Histopathology platform for analysis of tumor microenvironment and immune cells infiltrates (Collaborative Research Centres)
  - Predicting patterns of adaptation to radio-chemotherapy in cancer (Collaborative Research Centres)
As Participating Person
- Completed projects
  - Deregulation von Zell-Matrix-Kontakten bei invasiven und metastatischen Melanomzellen; molekulare Funktion des Proteins MIA (Research Grants)
  - Deregulation von Zell-Matrix-Kontakten bei invasiven und metastatischen Melanomzellen; molekulare Funktion des Proteins MIA (Priority Programmes)
  - Aktivierung mesenchymaler Zellen durch FHL2-vermittelte Signaltransduktion bei intestinaler Reparatur (Clinical Research Units)
  - Funktionelle Analysen von Ets-Transkriptionsfaktoren sowie Ets-Fusionstranskripten in Prostatakarzinomen (Research Grants)
As Co-Investigator
- Completed projects
  - Understanding mechanisms of drug resistance and clonal evolution in diffuse large B cell lymphoma (Research Grants)

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