Universitätsklinikum Freiburg
Institut für Klinische Pathologie
Address
Breisacher Straße 115a
79106 Freiburg
Deutschland
GERiT
This institution in GERiT
79106 Freiburg
Projects
Research Fellowships
Completed projects
Characterizing the mechanisms controlling the rate of adipogenesis in vitro and in vivo
(Applicant
Tholen, Stefan
)
Effects of a microsporidian parasite on populations of its host
(Applicant
Lass, Sandra
)
Research Grants
Current projects
Artificial Intelligence based Multiomics for Personalized Outcome Prediction after Radiation Therapy in Primary Prostate Cancer Patients
(Applicant
Spohn, Simon
)
Characterization and mode of action of Cochlin LCCL domain as a new host-targeted immunostimulating therapy against bacterial infections
(Applicants
Nyström, Alexander
;
Schilling, Oliver
)
Proteom biology of peri-implant inflammation for perspective early detection
(Applicants
Fretwurst, Tobias
;
Kreutz, Clemens
)
Completed projects
Cell-matrix interactions of renal tubular epithelial cells: implications of cortical actin structures and the tubular basement
(Applicant
Schell, Christoph B.
)
Entwicklung einer Biochip-Technologieplattform für simultane Genexpressions- und Mutationsanalyse
(Applicants
Rühe, Jürgen
;
Stickeler, Elmar
;
Werner, Martin
)
Funktionelle Charakterisierung der Chromosomensegregation in chromosomal instabilen kolorektalen Karzinomen
(Applicant
Laßmann, Silke
)
Impact of the aberrant cell-matrix interaction in Non-Alcoholic fatty liver diseases progression
(Applicants
Grimm, Dirk
;
Orian-Rousseau, Véronique
;
Schilling, Oliver
)
Impact of the transcription factor c-Jun/AP-1 and related signaling pathways on the progression from non-alcoholic fatty liver disease to steatohepatitis and hepatocellular carcinoma
(Applicant
Hasselblatt, Peter
)
Modulation of the podocyte actin network
(Applicants
Huber, Tobias B.
;
Schell, Christoph B.
)
Molekulare Genetik und Pathogenese des Hämolytisch-Urämischen Syndroms im Erwachsenenalter
(Applicant
Zipfel, Peter F.
)
Netherton Syndrome: From mechanisms to therapeutics
(Applicant
Schilling, Oliver
)
Phäno- und Genotypisierung von disseminierten Tumorzellen im Knochenmark von Mamma- und Ovarialkarzinom-Patientinnen
(Applicant
Braun, Stephan
)
Processed Sonic hedgehog - an active signaling protease?
(Applicants
Grobe, Kay
;
Schilling, Oliver
)
Prognostic value of pretherapeutic hypoxia and perfusion examination with 18F-MISO- and 15O-H2O-PET for the response evaluation of oesophageal carcinoma to a neoadjuvant therapy
(Applicant
Brink, Ingo
)
Proteomics and metabolomics systems analysis of envenomation by Bothrops snakes and antivenom effects using a murine model
(Applicant
Schilling, Oliver
)
Robust centrifugal microfluidic miniaturization and automation of target enrichment for protease substrate identification
(Applicants
Paust, Nils
;
Schilling, Oliver
)
Tracing the untackled facets of Peeling Skin Disease-Targeting epidermal proteolysis for treatment
(Applicant
Schilling, Oliver
)
Heisenberg Professorships
Completed projects
Proteolytic Determinants of Cellular Behavior in Health and Disease
(Applicant
Schilling, Oliver
)
Clinical Research Units
Current projects
Central mouse generation, phenotyping and imaging
(Applicants
Bozek, Katarzyna
;
Schauss, Astrid
)
KFO 329: Disease pathways in podocyte injury – from molecular mechanisms to individualized treatment options
(Spokesperson
Benzing, Thomas
)
MCD/FSGS registry and digital nephropathology
(Applicants
Grundmann, Franziska
;
Johannis, Wibke
;
Weber, Lutz T.
)
Role of the podocyte adhesome in the development of FSGS
(Applicant
Schell, Christoph B.
)
Heisenberg Grants
Current projects
Morpho-functional decoding of cell-matrix interactions in nephro-/uropathological disease
(Applicant
Schell, Christoph B.
)
Completed projects
Functional and Translational Proteome Research
(Applicant
Schilling, Oliver
)
Collaborative Research Centres
Current projects
Immunopathology Unit
(Project Heads
Bengsch, Ph.D., Bertram
;
Schell, Christoph B.
)
VHL-dependent licensing of hetero-cellular crosstalks within the tumor micro-environment of clear cell renal cell carcinoma (ccRCC)
(Project Heads
Schell, Christoph B.
;
Schilling, Oliver
)
Completed projects
Epigenetic regulation of esophageal cancer
(Project Head
Laßmann, Silke
)
ErbB, Src and interactive signaling pathways in esophageal cancers
(Project Head
Laßmann, Silke
)
Erkennung von Lymphomzellen durch menschliche Vy9/Vo2 T-Lymphozyten
(Project Head
Fisch, Paul
)
Ex-vivo-Untersuchungen zur Induktion einer Immunantwort gegen tumorassoziierte Antigene durch antigenpräsentierende Zellen
(Project Head
Fisch, Paul
)
Ex-vivo-Untersuchungen zur Induktion einer Immunantwort gegen tumorassoziierte Antigene durch Antigen-präsentierende Zellen beim Ovarialkarzinom
(Project Head
Fisch, Paul
)
Humane NK-Zell und T-Zell Subpopulationen bei primärer und sekundärer Immundefizienz
(Project Head
Fisch, Paul
)
Integrating signaling networks of cell adhesion, cell motility, and tumor-stroma interactions
(Project Heads
Dengjel, Jörn
;
Schilling, Oliver
)
Molecular and Cellular Analyses in Primary and Secondary Immunodeficiencies
(Project Head
Fisch, Paul
)
Pathomorphologische und zellbiologische Untersuchungen
(Project Heads
Follo, Ph.D., Marie
;
Kleinschmidt, Manuela
;
Köhler, Gabriele
)
Systems biology, pathology and proteomics
(Project Heads
Busch, Hauke
;
Börries, Melanie
;
Laßmann, Silke
;
Schilling, Oliver
)
Emmy Noether International Fellowships
Completed projects
System-wide identification of novel, bioactive substrates of matrix metalloprotease (MMP)-2 and dissection of a novel MMP-2 activation pathways
(Applicant
Schilling, Oliver
)
Emmy Noether Independent Junior Research Groups
Completed projects
Substrate Profiling of Cysteine Proteases in Physiology and Pathology
(Applicant
Schilling, Oliver
)
Major Research Instrumentation
Completed projects
Hybrid ESI/MALDI mass spectrometer with trapped ion mobility spectrometry
Research Training Groups
Current projects
GRK 2344: MeInBio - BioInMe: Exploration of spatio-temporal dynamics of gene regulation using high-throughput and high-resolution methods
(Spokesperson
Vogel, Tanja
)
GRK 2606: Understanding protease functions in cellular pathways through discovery and analysis of protease substrates (ProtPath)
(Spokesperson
Reinheckel, Thomas
)
Graduate Schools
Completed projects
GSC 4: Molecular Cell Research in Biology and Medicine (MOBILMED)
(Spokesperson
Borner, Christoph
)
