Universitätsklinikum Tübingen
Institut für Medizinische Mikrobiologie und Hygiene
Address
Elfriede-Aulhorn-Straße 6
72076 Tübingen
Deutschland
GERiT
This institution in GERiT
72076 Tübingen
Projects
Research Grants
Completed projects
1. "Role of dendritic cells in induction or prevention of colitogenic CD4 T cell responses" and 2. "Priming tolerogenic and colitogenic CD4 T cells in the murine gut"
(Applicants
Frick, Julia-Stefanie
;
Niess, Jan-Hendrik
)
Aktivierung von C. albicans Pathogenitätsfaktoren durch den Transkriptionsfaktor CaTec1p
(Applicant
Schröppel, Klaus
)
Analyses of murine neutrophil granulocyte steady-state homeostatic regulation
(Applicant
Bugl, Stefanie
)
Der Lebenszyklus ausgewählter Staphylococcus aureus Phagen, dessen Beeinflussung durch infektions-relevante Stimuli und die damit verbundene Modulation des Virulenzpotentials von S. aureus
(Applicant
Wolz, Christiane
)
Die infektionsbiologische Bedeutung von GILZ: ein möglicher Immunevasionsmechanismus von Yersinia enterocolitica
(Applicant
Bohn, Erwin
)
Identification and evaluation of peptides for active and passive immunization against Pseudomonas aeruginosa
(Applicants
Autenrieth, Ingo Birger
;
Linke, Dirk
)
Identifizierung und Struktur/Funktionsanalyse der Protein-Nitrierung in eosinophilen Granulozyten und in chronisch entzündetem murinem und humanem Lungengewebe durch hochauflösende Proteomanalyse
(Applicants
Döring, Gerd
;
Przybylski, Ph.D., Michael
)
Investigating the role of the uncharacterized gene ygfB in the resistance of multidrug resistant Pseudomonas aeruginosa to β-lactam antibiotics
(Applicant
Bohn, Erwin
)
Mechanism of type VI secretion system 5-dependent intercellular spread of Burkholderia pseudomallei
(Applicant
Schwarz, Sandra
)
Molecular mechanism of dendritic cell semimaturation and role in maintenance of intestinal homeostasis
(Applicant
Frick, Julia-Stefanie
)
Molecular mechanisms required for injection of Yersinia outer proteins (Yops) into host cells, and consequences for the host immune response
(Applicant
Autenrieth, Ingo Birger
)
Molekulare Charakterisierung des globalen Virulenzregulators sae von Staphylococcus aureus in vitro und in vivo
(Applicant
Wolz, Christiane
)
Post-translational regulation of the exopolysaccharide alginate in Pseudomonas aeruginosa
(Applicant
Schwarz, Sandra
)
Regulation of Pseudomonas aeruginosa gene expression under low oxygen tensions
(Applicant
Döring, Gerd
)
Regulation of the intercellular adhesin (ica) locus under anaerobic conditions in Staphylococcus aureus
(Applicant
Döring, Gerd
)
Regulation von potentiellen Adhärenzfaktoren bei Staphylococcus aureus
(Applicant
Wolz, Christiane
)
Role of different Lipid A structures of commensal bacteria in the regulation of colitogenic CD4+ T cell responses
(Applicant
Frick, Julia-Stefanie
)
Studium der Regulation der Hefen-Hyphen Transition von Candida albicans durch die Proteinphosphatase CPP1
(Applicant
Schröppel, Klaus
)
The role of IFIT-2 in local and systemic inflammation
(Applicant
Bohn, Erwin
)
The role of invariant NKT cells in cystic fibrosis
(Applicant
Döring, Gerd
)
The role of RNases in mRNA and rRNA processing in the human pathogen Staphylococcus aureus
(Applicant
Wolz, Christiane
)
Priority Programmes
Current projects
Molecular cross-talk between Sa3int phages and their Stapylococcus aureus host
(Applicant
Wolz, Christiane
)
STAPHEX II: Dissecting Staphylococcus aureus macrophage exit
(Applicants
Weber, Ph.D., Alexander
;
Wolz, Christiane
)
Completed projects
Interaction between Yersinia enterocolitica, the intestinal microbiota, and the host: from molecular analysis to therapeutic intervention
(Applicants
Autenrieth, Ingo Birger
;
Huson, Daniel H.
)
Mechanisms of (p)ppGpp action in Staphylococcus aureus
(Applicant
Wolz, Christiane
)
Molekulare Aspekte der infektionsspezifischen Anpassung von Staphylococcus aureus
(Applicant
Wolz, Christiane
)
Oxygen-dependent regulation of a diguanylate cyclase lacking canonical sensory and regulatory domains in Pseudomonas aeruginosa
(Applicant
Schwarz, Sandra
)
Staphylococcus aureus infection of endothelial cells
(Applicant
Peschel, Andreas
)
Studies on molecular mechanics of Candida albicans virulence gene regulation by the TEA transcription factor CaTec1p
(Applicant
Schröppel, Klaus
)
Therapy of IBD: Identification of bacteria, bacterial components and the host intestinal immune mechanisms
(Applicant
Frick, Julia-Stefanie
)
Research Fellowships
Completed projects
Analysis of the dynamics of the cellular immune response during abscess formation by intravital two-photon-microscopy
(Applicant
Liese, Jan
)
Discovery and distribution of natural product biosynthesis pathways in the marine actinomycetes Salinispora
(Applicant
Ziemert, Nadine
)
MHC-II abhängige Aktivierung von T-Zellen durch das zwitterionische Zellwandpolymer Wandteichonsäure von Staphylococcus aureus
(Applicant
Weidenmaier, Christopher
)
Role of type VI secretion in Burkholderia pseudomallei virulence and host interaction
(Applicant
Schwarz, Sandra
)
Collaborative Research Centres
Completed projects
A compound for prevention and therapy of inflammatory bowel diseases
(Project Head
Frick, Julia-Stefanie
)
Bacteriophage-host interaction at the cell envelope of Gram-positive pathogens
(Project Heads
Goerke, Christiane
;
Peschel, Andreas
;
Xia, Guoqing
)
Biogenesis of autotransporter adhesins of enteropathogenic Gram-negative bacteria
(Project Heads
Autenrieth, Ingo Birger
;
Schütz, Monika
)
Bistable expression of secondary cell wall glycopolymer biosynthesis genes: underlying mechanism and impact on virulence
(Project Heads
Weidenmaier, Christopher
;
Wolz, Christiane
)
Integrated Research Training Group "Immunotherapy"
(Project Heads
Frick, Julia-Stefanie
;
Hartl, Dominik
)
Mechanisms governing polar localization and assembly of the host cell targeting type VI secretion system
(Project Head
Schwarz, Sandra
)
Structure-function relationship of zwitterionic cell wall polymer dependent immune modulatory mechanisms
(Project Head
Weidenmaier, Christopher
)
CRC/Transregios
Current projects
Microbiota-dependent expression of IL22 by group 3 innate lymphoid cells regulates skin mesenchymal and epithelial cell differentiation
(Project Heads
Diefenbach, Andreas
;
Wolz, Christiane
)
Completed projects
Adaptation mechanisms of actinomycetes to the production of a variety of antibiotics
(Project Heads
Stegmann, Ph.D., Efthimia
;
Ziemert, Nadine
)
Role of the stringent response in bacterial survival, antibiotic tolerance and cell death
(Project Head
Wolz, Christiane
)
The impact of the host glyco-receptor repertoire on staphylococcal tissue specificity
(Project Head
Weidenmaier, Christopher
)
Research Training Groups
Completed projects
GRK 685: Infection Biology
(Spokesperson
Götz, Friedrich
)
GRK 1708: Molecular Principles of Bacterial Survival Strategies
(Spokesperson
Forchhammer, Karl
)
Clusters of Excellence (ExStra)
Current projects
EXC 2124: Controlling Microbes to Fight Infections (CMFI)
(Spokespersons
Brötz-Oesterhelt, Heike
;
Ley, Ph.D., Ruth
;
Peschel, Andreas
)
