Universitätsklinikum Tübingen
Medizinische Universitätsklinik
Abteilung Innere Medizin II
Address
Otfried-Müller-Straße 10
72076 Tübingen
Deutschland
GERiT
This institution in GERiT
72076 Tübingen
Projects
Research Grants
Current projects
De novo design of miniaturised G-CSFR agonists
(Applicants
ElGamacy, Ph.D., Mohammad
;
Hernandez Alvarez, Birte
;
Skokowa, Ph.D., Julia
)
Investigating enhanced intracellular stress response in leukemic stem cells as a mechanism of disease persistence in acute myeloid leukemia associated with severe congenital neutropenia
(Applicants
Claassen, Ph.D., Manfred
;
Skokowa, Ph.D., Julia
)
MAT2A as key regulator and therapeutic target in MLL leukemogenesis
(Applicant
Schneidawind, Ph.D., Corina
)
Medical Innovation through Interdisciplinarity Clinician Scientist (MINT-CS) program
(Applicant
Lengerke, Claudia
)
Modulation of B effector cells and regulatory B cells by iNKT cells in systemic sclerosis patients
(Applicant
Schneidawind, Dominik
)
Pathophysiological mechanisms of JAGN1-associated severe congenital neutropenia
(Applicants
Klimiankou, Ph.D., Maksim
;
Skokowa, Ph.D., Julia
)
Targeting persistent leukemic cells by combined treatments with NKG2D ligand inducers and engineered NK/T cells
(Applicants
Lengerke, Claudia
;
Seitz, Christian
)
Completed projects
Analyses of murine neutrophil granulocyte steady-state homeostatic regulation
(Applicant
Bugl, Stefanie
)
Bedeutung ausgewählter Stammzellmarkern in metastasierten und nicht-metastasierten Plattenepithelkarzinomen sowie deren Vorläuferläsionen
(Applicants
Lengerke, Claudia
;
Perner, Sven
)
Die Analyse der Interaktion zwischen dem Transkriptionsfaktor LEF-1 und der Neutrophilen Elastase in der Granulopoese: die funktionelle Rolle von ELA2 Mutationen bei Patienten mit schwerer angeborener Netropenie.
(Applicant
Skokowa, Ph.D., Julia
)
Evaluation of muscarinic acetylcholine receptors type 3 in the pathogenesis of chronic inflammatory cholangiopathies
(Applicants
Benckert, Julia
;
Berg, Thomas
;
Klein, Reinhild
)
G-CSF-dependent de-/acetylation of myeloid-specific transcription factors LEF 1 and C/EBPalpha in myeloid differentiation and leukemogenesis
(Applicant
Skokowa, Ph.D., Julia
)
Humanized NSG mouse model to study combinatorial leukemogenic effects of inherited ELANE and acquired CSF3R/RUNX1 mutations in congenital neutropenia
(Applicants
Skokowa, Ph.D., Julia
;
Welte, Karl
)
Identifizierung und funktionelle Untersuchung von humanen adulten spermatogonalen und germalen Stammzellen
(Applicant
Skutella, Thomas
)
Identifizierung und funktionelle Untersuchung von MSC-spezifischen Molekülen
(Applicants
Bühring, Hans-Jörg
;
Lammers, Reiner
)
Isolierung und Charakterisierung von Stammzellsubpopulationen mit mesenchymalem und hämatopoetischem Differenzierungspotential
(Applicant
Wiesmann, Anne
)
Molekulare und funktionelle Untersuchungen zur Differenzierung und Funktion humaner dendritscher Zellen
(Applicant
Grünebach, Frank
)
Nachweis und Charakterisierung disseminierter und zirkulierender Tumorzellen beim Ovarialkarzinom zur Etablierung und Optimierung neuer zielgerichteter Therapiestrategien
(Applicants
Kasimir-Bauer, Sabine
;
Neubauer, Ph.D., Hans
)
One gene, two phenotypes – understanding the pathomechanics and leukemia development in congenital neutropenia and cyclic neutropenia
(Applicant
Skokowa, Ph.D., Julia
)
The Biological and Clinical Relevance of EVI1 Expression in Prostate Carcinogenesis
(Applicant
Perner, Sven
)
The role of NAMPT/SIRTs signaling in hematopoietic differentiation
(Applicant
Skokowa, Ph.D., Julia
)
Priority Programmes
Completed projects
Analysis of the interaction between Aspergillus fumigatus and human dendritic cells and the induction of innate and adaptive immune responses to the pathogen
(Applicant
Einsele, Hermann
)
Collaborative Research Centres
Completed projects
Development of therapeutic antibodies for the elimination of tumor stem cells
(Project Heads
Bühring, Hans-Jörg
;
Große-Hovest, Ludger
;
Jung, Gundram
)
Die Funktion chemotaktischer Rezeptoren bei der Migration hämatopoetischer Stammzellen in vitro und in vivo
(Project Heads
Möhle, Robert
;
Schick, Fritz
)
Entwicklung von monoklonalen Antikörpern für die Isolierung von seltenen hämapoetischen Zellpopulationen sowie die molekulare Charakterisierung der erkannten Antigene
(Project Heads
Bühring, Hans-Jörg
;
Lammers, Reiner
)
Identification and targeting of self-renewal pathways in cancer stem cells to overcome drug resistance
(Project Heads
Kopp, Hans-Georg
;
Lengerke, Claudia
)
Identifizierung differenziell exprimierter Gene in dendritischen Zellen
(Project Heads
Brossart, Peter
;
Grünebach, Frank
)
Individualized MHC-II-peptide vaccination in combination with adoptive T-cell transfer after lymphodepletion in malignant melanoma
(Project Heads
Garbe, Claus
;
Schmidt, Susanne Maleika
)
Modulation of NK-cell-mediated tumor immunosurveillance by platelets
(Project Heads
Kopp, Hans-Georg
;
Salih, Helmut Rainer
)
Molekulare und funktionelle Untersuchungen zur Differenzierung und Funktion humaner dendritischer Zellen
(Project Heads
Brossart, Peter
;
Grünebach, Frank
)
Zellsortierung
(Project Head
Bühring, Hans-Jörg
)
WBP Fellowship
Current projects
Comprehensive profiling of transcriptional regulation to overcome and prevent adaptive Menin inhibitor resistance in KMT2A-rearranged and NPM1-mutated AML
(Applicant
Schröder, Jan Christian
)
Completed projects
Impact of intratumor heterogeneity on anti-tumor immune responses in non-small cell lung cancer
(Applicant
Rörden, Malte Carl
)
Major Research Instrumentation
Completed projects
3-Laser Flow cytometer
4-laser cell sorter
4-laser flow cytometer
5-laser spectral analyzer
Platform for the automatic production of cellular products
CRC/Transregios
Completed projects
TRR 240: Platelets – Molecular, cellular and systemic functions in health and disease
(Spokesperson
Nieswandt, Bernhard
)
Research Training Groups
Completed projects
GRK 794: Cellular Mechanisms of Immune-Associated Processes
(Spokesperson
Rammensee, Hans-Georg
)
Clusters of Excellence
Completed projects
EXC 62: From Regenerative Biology to Reconstructive Therapy (REBIRTH)
(Spokespersons
Haverich, Axel
;
Thum, Ph.D., Thomas
)
