Universitätsklinikum Heidelberg
Department für Infektiologie
Abteilung Parasitologie
Address
Im Neuenheimer Feld 324
69120 Heidelberg
Deutschland
GERiT
This institution in GERiT
69120 Heidelberg
Projects
Priority Programmes
Current projects
Exit of Plasmodium gametes from red blood cells
(Applicant
Frischknecht, Friedrich
)
Structural determinants and function of chirality in the motion of malaria parasites
(Applicants
Frischknecht, Friedrich
;
Schwarz, Ulrich
)
Completed projects
Functional characterization of the Plasmodium falciparum sodium/hydrogen ion exchanger and its role in chloroquine resistance
(Applicant
Lanzer, Michael
)
Identification of signals and factors facilitating transport of STEVOR to the Maurer`s clefts of Plasmodium falciparum
(Applicant
Lanzer, Michael
)
Impaired trafficking and transfer of virulence factors to the surface of P. falciparum-infected erythrocytes containing the hemoglobin polymorphisms HbS and HbC
(Applicant
Lanzer, Michael
)
Malaria intrahepatic interactions and trafficking: Deciphering the molecular machinery driving vesicular trafficking and membrane fusion between the hepatic host environment and malarial parasite for parasitophorous vacular membrane dynamics
(Applicant
Müller, Ann-Kristin
)
Using dynamic light microscopy and cryo-electron tomography we will investigate the actin cytoskeleton during gliding motility of malaria parasites
(Applicant
Frischknecht, Friedrich
)
We will probe the function of two potential formin-like actin nucleation factors in malaria parasite adhesion and motility using recently developed quantitative imaging tools
(Applicant
Frischknecht, Friedrich
)
Research Fellowships
Completed projects
Antigenic variation in Plasmodium falciparum malaria: The role of the intron promoter in var gene silencing
(Applicant
Epp, Christian
)
Genetic manipulation of erythrocytes: Identification and characterization of essential host cell determinants for Plasmodium infection
(Applicant
Ganter, Markus
)
Research Grants
Completed projects
Integrative analysis of nuclear division mechanisms in malaria parasite
(Applicant
Guizetti, Julien
)
Microtubule stability and dynamics in Plasmodium sporozoites
(Applicant
Frischknecht, Friedrich
)
Plasmodium coronin function during malaria parasite migration
(Applicant
Frischknecht, Friedrich
)
Plasmodium sporozoite neutralization in the host skin
(Applicant
Frischknecht, Friedrich
)
The evolution of PfCRT from a carrier with a natural function to a drug transporting system in Plasmodium falciparum
(Applicant
Lanzer, Michael
)
Collaborative Research Centres
Current projects
Deciphering receptor-ligand interplay during rapid motility of Plasmodium sporozoites
(Project Heads
Frischknecht, Friedrich
;
Spatz, Joachim P.
)
Deciphering the regulation of Plasmodium falciparum replication
(Project Heads
Ganter, Markus
;
Portugal, Silvia
)
Modeling the adhesion of malaria-infected red blood cells
(Project Heads
Lanzer, Michael
;
Schwarz, Ulrich
)
Protection of malaria by haemoglobin S and C: A quantitative understanding of the cytoadhesion behavior
(Project Heads
Lanzer, Michael
;
Tanaka, Motomu
)
The role of mechanosensing and antibodies for interactions of Plasmodium sporozoites with neutrophils in 3D environments
(Project Heads
Frischknecht, Friedrich
;
Selhuber-Unkel, Christine
)
Completed projects
Analysis of Plasmodium sporozoite adhesion and gliding
(Project Head
Frischknecht, Friedrich
)
Biochemical and genetic analysis of quinine resistant malaria
(Project Head
Lanzer, Michael
)
Role of intra- and extra-cellular host miRNAs as regulators of Plasmodium liver stages
(Project Heads
Grimm, Dirk
;
Müller, Ann-Kristin
)
Untersuchungen zur Expression und Funktion von var-Genen bei Plasmodium falciparum
(Project Head
Lanzer, Michael
)
Major Research Instrumentation
Completed projects
Inverted confocal live cell imaging microscope
Inverted multiphoton microscop
Research Training Groups
Completed projects
GRK 1188: Quantitative Analysis of Dynamic Processes in Membrane Transport and Translocation
(Spokespersons
Fackler, Ph.D., Oliver T.
;
Nickel, Walter
)
Graduate Schools
Completed projects
GSC 249: The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology
(Spokesperson
Wittbrodt, Joachim
)
