Goethe-Universität Frankfurt am Main
Buchmann Institute for Molecular Life Sciences
Address
Max-von-Laue-Straße 15
60438 Frankfurt am Main
Deutschland
GERiT
This institution in GERiT
60438 Frankfurt am Main
Projects
Research Grants
Current projects
A sleep- and locomotion stop neuron with compartmentalized Ca2+ dynamics as a CPG regulator?
(Applicant
Gottschalk, Alexander
)
Characterization of catecholaminergic polymorphic ventricular tachycardia (CPVT) mutations and specific drug screen in the pharynx of C. elegans as an optogenetic arrhythmia model
(Applicant
Schüler, Christina
)
Derivatization of polyketides during their biosynthesis
(Applicant
Grininger, Martin
)
Development of a Chem-CRISPR/dCas9 system to achieve small-molecule-mediated epigenetic regulation at the single-gene level
(Applicant
Cheng, Xinlai
)
Mechanisms of specific (co-)transmission of distinct neuropeptides from a single neuron
(Applicant
Gottschalk, Alexander
)
Pro(teasome targeting)-PROTACs: Advancing Targeted Protein Degradation with a Proteasome Binder Approach
(Applicant
Cheng, Xinlai
)
Seeking for small molecules to improve the efficiency and specificity of CRISPR-Cas9-mediated genome editing
(Applicant
Cheng, Xinlai
)
Understanding substrate translocation in polyketide synthase (PKS) assembly lines
(Applicant
Grininger, Martin
)
Completed projects
Analyzing multigenerational effects of the Piwi/piRNA pathway in zebrafish.
(Applicant
Dill, Holger
)
Feasibility study to assess the ecotoxicological and toxicological impact on sediments as a result of the July 2021 flood in the transition from the low mountain range to the lowlands.
(Applicants
Brüll, Catrina
;
Hollert, Henner
;
Oehlmann, Jörg
;
Schiwy, Sabrina
;
Strobl, Frederic
)
Functional analysis of novel proteins associated with nicotinic acetylcholine receptors and synaptic vesicles in Caenorhabditis elegans
(Applicant
Gottschalk, Alexander
)
Functional and structural characterization of the fatty acid synthase type I from Mycobacterium tuberculosis
(Applicant
Grininger, Martin
)
Identification, characterization and optimization of chemicals for the generation of human chemically induced pluripotent stem cells
(Applicant
Cheng, Xinlai
)
New Light-Driven Channels and Transporters for Optogenetics
(Applicants
Fahlke, Christoph
;
Gottschalk, Alexander
)
Optogenetic Analysis of neuropeptidergic regulation of fast synaptic transmission at the zebrafish neuromuscular junction
(Applicant
Gottschalk, Alexander
)
Heisenberg Professorships
Completed projects
Molekulare und Zelluläre Biochemie
(Applicant
Gottschalk, Alexander
)
Research Units
Completed projects
Developing and implementing novel light-switches in the nervous system of the nematode
(Applicant
Gottschalk, Alexander
)
Regulation of cell contacts and cell shape during mouth formation in Caenorhabditis elegans
(Applicants
Kaschube, Matthias
;
Pohl, Christian
)
Priority Programmes
Completed projects
Coordination Funds
(Applicant
Gottschalk, Alexander
)
Going full circle - optogenetic control of Ca2+ release from and reuptake into the endoplasmic reticulum
(Applicants
Gottschalk, Alexander
;
Lehnart, Stephan E.
;
Sasse, Philipp
)
SPP 1926: Next Generation Optogenetics: Tool Development and Application
(Spokesperson
Gottschalk, Alexander
)
Collaborative Research Centres
Current projects
Imaging and phenotypical screening platform
(Project Heads
Eimer, Stefan
;
Heilemann, Mike
;
Pohl, Christian
;
Stolz, Alexandra
;
Wilfling, Florian
)
Integrated Research Training Group (IRTG)
(Project Heads
Behl, Christian
;
Bremm, Anja
;
Dötsch, Volker
;
Pohl, Christian
)
Molecular principles guiding lipid structure and function of autophagosomes
(Project Heads
Bhaskara, Ph.D., Ramachandra M.
;
Kern, Andreas
;
Pohl, Christian
)
Optogenetic analysis of membrane compartmentalization between and within excitable cells
(Project Head
Gottschalk, Alexander
)
Completed projects
Functional Analysis of Novel Proteins Associated with Nicotinic Acetylcholine Receptors and Synaptic Vesicles in Caenorhabditis elegans
(Project Head
Gottschalk, Alexander
)
Microbial rhodopsins as optogenetic tools to analyze neuronal networks in the nematode Caenorhabditis elegans
(Project Head
Gottschalk, Alexander
)
Proteomic and funkctional analysis of pre- and post-synaptic componentes in Caenorhabditis elegans
(Project Head
Gottschalk, Alexander
)
Regulation of presynaptic homeostasis at the level of synaptic vesicle filling, mobilization, fusion and recycling
(Project Head
Gottschalk, Alexander
)
Major Research Instrumentation
Completed projects
Hochdruckgefrierer mit integrierter Lichtstimulation
Research Training Groups
Current projects
GRK 2566: Interfacing image analysis and molecular life-science (Imol)
(Spokesperson
Frangakis, Achilleas
)
Clusters of Excellence
Completed projects
EXC 115: Macromolecular Complexes
(Spokespersons
Dötsch, Volker
;
Schwalbe, Harald
)
