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Institution
University of Luxembourg
Luxembourg Centre for Systems Biomedicine (LCSB)
Address
7, avenue des Hauts-Fourneaux
4362 Esch-sur-Alzette
Luxemburg
4362 Esch-sur-Alzette
Projects
Priority Programmes
Completed projects
Die molekulare Basis von Skelettmißbildungen
(Applicant
Balling, Ph.D., Rudi
)
Function of cell fate determinants during acquisition and loss of pluripotency
(Applicant
Schwamborn, Jens Christian
)
Herstellung von transgenen Mäusen durch "knock-in" mutierter FGFR2-Gene
(Applicant
Müller, Ulrich
)
Herstellung von transgenen Mäusen durch "knock-in" mutierter FGFR2-Gene
(Applicant
Balling, Ph.D., Rudi
)
Research Grants
Current projects
CHAnging Rare disorders of LysInE metabolism
(Applicants
Hrabe de Angelis, Martin
;
Kölker, Stefan
)
Improving the performance of polygenic scores in diverse populations
(Applicants
Caliebe, Amke
;
Nothnagel, Ph.D., Michael
)
Overcoming Bias and Data Inhomogeneity in Machine Learning: COVID-19 Imaging and Beyond
(Applicants
Bernard, Ph.D., Florian
;
Cremers, Daniel
)
The role of ER-mitochondria signalling in PRKN-associated Parkinson´s disease
(Applicant
Grossmann, Dajana
)
Tracking and Reconstructing Interactions to Understand the Missing Parts of Heritability (TRIUMPH).
(Applicants
Gagneur, Julien
;
Steinmetz, Ph.D., Lars
)
Completed projects
A network-based approach to modelling cell-niche interactions and its application to studying salamander limb regeneration
(Applicant
Tanaka, Ph.D., Elly Margaret
)
Complex genetics of idiopathic epilepsies
(Applicants
Lerche, Holger
;
Neubauer, Bernd A.
;
Nürnberg, Peter
)
Die Rolle konstitutiver und immunstimulierter Stickoxid-(NO) Bildung in der Alzheimer Erkrankung
(Applicant
Heneka, Michael Thomas
)
DJ1 Linked Neurodegeneration Pathways in New Mouse Models of Parkinson s Disease
(Applicant
Wurst, Wolfgang
)
Mechanisms of Neuronal Dysfunction and Death in Sepsis-induced Cognitive Impairment
(Applicants
Emmrich, Julius
;
Heneka, Michael Thomas
;
Neher, Ph.D., Jonas
)
Multiplexed point-of-care testing for inflammatory miRNA and neurotransmitter profiling in Alzheimer’s disease diagnostics
(Applicants
Dincer, Can
;
Heneka, Michael Thomas
)
Nitration of Amyloid beta Alzheimer 's disease
(Applicant
Heneka, Michael Thomas
)
Non-invasive microbiome-derived multi-omic biomarkers for the early-stage detection and stratification of Parkinson disease
(Applicants
Mollenhauer, Brit
;
Oertel, Wolfgang
)
Peroxisom Proliferator aktivierter Rezeptor Gamma (PPAR Gamma) vermittelte Modulation neuroinflammatorischer und neurodegenerativer Mechanismen in der Alzheimer Erkrankung
(Applicant
Heneka, Michael Thomas
)
The role of Parkin in mitochondrial function and morphology
(Applicant
Grünewald, Anne
)
Clinical Research Units
Completed projects
Common resources of the Clinical Research Group
(Applicant
Heneka, Michael Thomas
)
KFO 177: Innate Immunity in Chronic Neurodegeneration
(Spokesperson
Klockgether, Thomas
)
Modulation of neurodegeneration and neuroinflamation by the liver X receptor (LXR) in Alzheimer`s disease
(Applicant
Heneka, Michael Thomas
)
Independent Junior Research Groups
Completed projects
Asymmetrische Zellteilung als Mechanismus der Regulation von Proliferation und Differenzierung adulter neuraler Stammzellen
(Applicant
Schwamborn, Jens Christian
)
The structural basis of mammalian prion interspecies transmissibility and strain specificity
(Applicant
Lührs, Thorsten
)
Collaborative Research Centres
Current projects
Metaflammation-induced acceleration of neurodegeneration
(Project Head
Heneka, Michael Thomas
)
Completed projects
Conserved polarity mechanisms in asymmetric cell division, neuronal polarization and neuronal migration
(Project Head
Schwamborn, Jens Christian
)
Locus coeruleus – mediated microglial senescence as a driver for tau pathology and neuronal network dysfunction
(Project Head
Heneka, Michael Thomas
)
Molekularbiologische Untersuchungen zur Pathogense des Plattenepithelkarzinoms
(Project Heads
Balling, Ph.D., Rudi
;
Höfler, Heinz
)
Stickoxid (NO) und neuronaler Zelltod
(Project Heads
Heneka, Michael Thomas
;
Klockgether, Thomas
)
Research Fellowships
Completed projects
Die Rolle mitochondrialer Mutationen bei neurodegenerativen Erkrankungen
(Applicant
Grünewald, Anne
)
Research Units
Current projects
Centralized data management and analysis facilities
(Applicant
Isbrandt, Dirk
)
FOR 2488: Reduced penetrance in hereditary movement disorders: Elucidating mechanisms of endogenous disease protection
(Spokesperson
Klein, Christine
)
FOR 2715: Epileptogenesis of genetic epilepsies
(Spokesperson
Lerche, Holger
)
Identifying Parkinson’s disease penetrance-modifying factors in the population-based Cooperative Health Research in South Tyrol (CHRIS) cohort
(Applicant
Klein, Christine
)
Maintenance and Extension of a Central Project Knowledge Base (CPKB), systems biomedicine and statistics pipeline
(Applicants
Busch, Hauke
;
Erdmann, Jeanette
;
Koenig, Inke Regina
;
Krawczak, Michael
)
Modifiers of Parkin and PINK1 mutation penetrance in Parkinson’s disease: Endogenous human models
(Applicant
Rakovic, Aleksandar
)
Molecular mechanisms defining penetrance of LRRK2-associated Parkinson’s disease
(Applicants
Grünewald, Anne
;
Kasten, Meike
;
Trinh, Ph.D., Joanne
)
Rare genetic factors in epileptogenesis
(Applicant
Lerche, Holger
)
Completed projects
Epileptogenesis and drug discovery in genetic epilepsy models in zebrafish
(Applicant
Skupin, Alexander
)
Clusters of Excellence (ExStra)
Current projects
EXC 2151: ImmunoSensation2 - the immune sensory system
(Spokespersons
Hartmann, Gunther
;
Kolanus, Waldemar
;
Latz, Eicke
;
Schultze, Joachim L.
)
Clusters of Excellence
Completed projects
EXC 1023: ImmunoSensation: The Immune Sensory System
(Spokesperson
Hartmann, Gunther
)
Additional Information
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