Friedrich-Alexander-Universität Erlangen-Nürnberg
Department Biologie
Lehrstuhl für Genetik
Address
Erwin-Rommel-Straße 3
91058 Erlangen
Deutschland
GERiT
This institution in GERiT
91058 Erlangen
Projects
Research Grants
Current projects
Deciphering the MLL induced oncogenic network
(Applicant
Slany, Robert
)
Understanding the Mincle-FcγR crosstalk in the regulation of autoantibody-dependent inflammation
(Applicants
Böckmann, Rainer
;
Nimmerjahn, Falk
)
Completed projects
Charakterisierung und therapeutische Inhibition der Komplementaktivierung in der experimentellen Epidermolysis bullosa acquisita
(Applicant
Mihai, Sidonia
)
Immortalization of hematopoietic precursor cells by the translocation-breakpoint protein MLL-ENL
(Applicant
Slany, Robert
)
Mechanisms of HOX-induced leukemogenesis
(Applicant
Slany, Robert
)
Pathogenicity of IgA-type autoantibodies in pemphigoid disease
(Applicants
Ludwig, Ralf Joachim
;
Nimmerjahn, Falk
;
Recke, Andreas
)
The molecular basis and functional consequences of IgG subclass glycosylation
(Applicant
Nimmerjahn, Falk
)
Transformation hämatopoietischer Zellen durch HOX-Homeoboxgene
(Applicant
Slany, Robert
)
Untersuchung des transformierenden Potentials der Translokations-Bruchpunktsproteine MLL/AF4 und AF4/MLL aus leukämischen pro-B Blasten mit Translokation t(4;11)
(Applicant
Fey, Georg H.
)
Research Units
Current projects
Deciphering the Function and Regulation of the B Cell Intrinsic a2,6-Sialylation Network
(Applicants
Nimmerjahn, Falk
;
Werner, Anja
)
FOR 2886: PANDORA - Pathways triggering AutoimmuNity and Defining Onset of early Rheumatoid Arthritis
(Spokesperson
Krönke, Gerhard
)
FOR 2953: Sialic Acid as Regulator in Development and Immunity
(Spokesperson
Mühlenhoff, Martina
)
FOR 5775: Macrophage Niche Network Dynamics - Defining macrophages as choreographers of tissue development and function
(Spokesperson
Mass, Elvira
)
Role of the materno-fetal IgG bone marrow macrophage axis for early B cell development
(Applicant
Nimmerjahn, Falk
)
Completed projects
Deciphering the stage specific impact of cellular and humoral components modulating the onset of RA
(Applicants
Lux, Anja
;
Nimmerjahn, Falk
)
Einfluss deregulierter oder funktionell inaktiver inhibitorischer Rezeptoren auf die Aufrechterhaltung der Toleranz im humoralen Immunsystem der humanisierten Maus
(Applicant
Nimmerjahn, Falk
)
Priority Programmes
Completed projects
Epigenetic consequences of MLL fusion protein expression
(Applicant
Slany, Robert
)
Impact of immunoglobulin G and Fc-gamma-receptors on osteoblast and osteoclast development and function in vitro and in vivo
(Applicant
Nimmerjahn, Falk
)
Collaborative Research Centres
Current projects
Cell subset-specific roles of FcRn in regulating autoantibody generation and activity in pemphigoid diseases
(Project Head
Nimmerjahn, Falk
)
Completed projects
Aktivator/Suppressor-Funktionen der Translokations-spezifischen Fusionsproteine MLL/AF-4 und AF-4/MLL
(Project Head
Fey, Georg H.
)
Bivalent recombinant antibody-derivates for the elimination of malignant AML cells
(Project Head
Fey, Georg H.
)
Charakterisierung der DNA-Bindungsdomäne und akzessorisher Faktoren des MLL-Proteins, eines Mitglieds der Trithorax Gruppe von Chromatin Organisator-Proteinen
(Project Head
Slany, Robert
)
Die Funktion des ENL (eleven-nineteen-leukemia) Proteins bei normaler und aberranter Transkription
(Project Head
Slany, Robert
)
Die Rolle des Transkriptionsfaktors ENL in der Leukämieentstehung durch das Fusionsonkogen ALL-1/ENL. Identifizierung vo Proteininteraktionspartnern des ENL
(Project Head
Slany, Robert
)
Harnessing monocyte and dendritic cell dependent pathways of IVIg activity to enhance resolution of inflammation
(Project Heads
Dudziak, Diana
;
Nimmerjahn, Falk
)
Identifikation einer optimalen Strategien zur Beladung dendritischer Zellen mit dem gesamten antigenen Repertoire von Tumorzellen: Vergleich von RNA-Transfektion und Aufnahme apoptotischer Partikel opsonisiert mit rekombinanten bispezifischen Antikörpern
(Project Heads
Fey, Georg H.
;
Kämpgen, Eckhart
)
Investigating the mechanism of antibody mediated effector functions in vivo
(Project Head
Nimmerjahn, Falk
)
Investigating the mechanism of antibody mediated effector functions in vivo
(Project Head
Nimmerjahn, Falk
)
Research Fellowships
Completed projects
Untersuchungen zur molekularen Wirkung von Anti-Tumor-Antikörpern in in vivo Tumormodellen der Maus
(Applicant
Nimmerjahn, Falk
)
Major Research Instrumentation
Completed projects
Zellanalyse- und Hochgeschwindigkeitssortiersystem
CRC/Transregios
Current projects
Modulating the tumor metastasis propagating and inhibiting effects of tumor associated macrophages via Fc-receptors
(Project Head
Nimmerjahn, Falk
)
Regulation of autoantibody in-duced bone inflammation and osteoclastogenesis via the C-type lectin receptor Mincle
(Project Head
Nimmerjahn, Falk
)
Completed projects
Deciphering the Regulation of the B Cell intrinsic Glycoslyation Network
(Project Heads
Lux, Anja
;
Nimmerjahn, Falk
)
Research Training Groups
Completed projects
GRK 592: Lymphocytes: Differentiation, Activation and Deviation
(Spokesperson
Jäck, Hans-Martin
)
GRK 1660: Key Signals of Adaptive Immune Response
(Spokesperson
Jäck, Hans-Martin
)
