Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)
Address
Universitätscampus E8.1
66123 Saarbrücken
Deutschland
GERiT
This institution in GERiT
66123 Saarbrücken
Projects
Research Grants
Current projects
Aniridia – Novel therapeutic tools to treat or prevent progressive cornea opacification
(Applicant
Szentmáry, Ph.D., Nóra
)
Characterization of novel natural product binding sites on the DNA-gyrase of multidrug resistant Mycobacterium tuberculosis and Neisseria gonorrhoea
(Applicants
Kazmaier, Uli
;
Müller, Rolf
;
Rybniker, Ph.D., Jan
)
Chemo-enzymatic Synthesis of Structurally Complex Sorbicillin-Derived Natural Products and Non-Natural Analogd
(Applicant
Gulder, Tobias A. M.
)
Harnessing the Mixing Power of the Microbial Secondary Metabolites Kaleidoscope: Bacterial Hybrid Terpene Biosynthetic Pathways
(Applicants
Luzhetskyy, Andriy
;
Müller, Rolf
)
The mRNA binding protein IMP2/IGF2BP2 as a target for anti-cancer therapy: target validation and hit-to-lead optimization
(Applicants
Empting, Martin
;
Kiemer, Alexandra K.
)
Completed projects
Biochemische Charakterisierung eines neuartigen Biosyntheseweges zu Startermolekülen für die Biogenese von Sekundärstoffen und verzweigtkettigen Fettsäuren in Myxobakterien
(Applicant
Müller, Rolf
)
Biomimetic synthesis, biosynthetic pathway engineering and structure activities studies of unique glycosolyated macrolactams
(Applicant
Beemelmanns, Christine
)
Controlled bacterial interaction to increase the antimicrobial efficiency of copper surfaces
(Applicants
Jacobs, Karin
;
Mücklich, Frank
;
Müller, Rolf
)
Design, synthesis and biological evaluation of inhibitors of 17-ß-Hydroxysteroid Dehydrogenase Type 1 (17ß-HSD1)
(Applicant
Hartmann, Rolf
)
Elucidation of the biosynthesis and the biological function of DKxanthenes during fruiting body formation in Myxococcus xanthus
(Applicant
Müller, Rolf
)
Entwicklung selektiver Inhibitoren der Aldosteronsynthase (CYP11B2) zur Therapie von Herzinsuffizienz und Myocardfibrose
(Applicant
Hartmann, Rolf
)
Entwicklung selektiver Inhibitoren der Steroid-11ß-Hydroxylase (CYP11B1) zur Therapie von Cushing- und Metabolischem Syndrom
(Applicant
Hartmann, Rolf
)
Enzyme structure based development of potent and selective inhibitores of 17ß-hydroxysteroid dehydrogenase type 2 for the treatment of osteoporosis
(Applicants
Adamski, Jerzy
;
Hartmann, Rolf
)
Exploitation and total synthesis of new microbial sphingolipid-type signaling molecules (EXSPHINGO)
(Applicant
Beemelmanns, Christine
)
Genetic modules for sensing and detoxification of novel antibacterial compounds
(Applicant
Halbedel, Sven
)
Influence of physicochemical properties of Nanoparticles on mucociliary and macrophage cleareance
(Applicant
Lehr, Ph.D., Claus-Michael
)
Molekularbiologische und biochemische Untersuchungen zur Bildung des Eisenchelators Myxochelin aus Stigmatella aurantiaca (Myxococcales)
(Applicant
Müller, Rolf
)
Molekularbiologische und biochemische Untersuchungen zur Biosynthese des Antibiotikums Myxothiazol aus Stigmatella aurantiaca (Myxococcales)
(Applicant
Müller, Rolf
)
Structure and biosynthesis of polycyclic tetramate macrolactams
(Applicant
Gulder, Tobias A. M.
)
Validation of 17beta-HSD2 inhibition as potential approach for the prevention of osteoporosis: comparison of in vivo efficacy and safety between a 17beta-HSD2 inhibitor and a specifically targeting bone 17beta-HSD2 inhibitor
(Applicants
Hartmann, Rolf
;
Vollmer, Günter
)
Priority Programmes
Current projects
Ecology and functions of small SCIFF proteins in the gut microbiome
(Applicants
Clavel, Thomas
;
Gulder, Tobias A. M.
)
Completed projects
Untersuchung der Funktion und Evolution von Typ III und Typ II Polyketidsynthasen in Mikrooganismen und Pflanzen
(Applicant
Müller, Rolf
)
Emmy Noether Independent Junior Research Groups
Completed projects
Development of novel biocatalysts for the chemo-enzymatic total synthesis of complex antiinvective peptide natural products and of analogs with optimized biological activity
(Applicant
Gulder, Tobias A. M.
)
WBP Return Grant
Completed projects
Rückkehrstipendium
(Applicant
Kiefer, Alexander
)
Rückkehrstipendium
(Applicant
Bader, Chantal
)
Clinical Research Units
Completed projects
Synthese und Wirkstoffdesign -Hemmung des CD81-vermittelten Hepatitis C-Virus Zelleintritts
(Applicant
Hartmann, Rolf
)
Research Units
Current projects
FOR 5170: CytoLabs – Systematic Investigation and Exploitation of Cytochalasans
(Spokesperson
Cox, Russell J.
)
OMICs based analysis of cytochalasans in fungal-bacteria-insect interactions
(Applicant
Beemelmanns, Christine
)
Completed projects
(Bio)Syntheses of chondramides and related cyclodepsipeptides
(Applicants
Kazmaier, Uli
;
Müller, Rolf
)
FOR 1406: Exploiting the Potential of Natural Compounds: Myxobacteria as Source for Leads, Tools and Therapeutics in Cancer Research
(Spokesperson
Vollmar, Angelika
)
Collaborative Research Centres
Current projects
Functional characterization of carcinogenic and inflammatory secondary metabolites from the intestinal microbiota
(Project Heads
Gulder, Tobias A. M.
;
Sieber, Stephan A.
;
Zeller, Georg
)
Isolation, Characterization and Functional Analysis of Novel Biomolecules from the Mutualistic Food Fungus and Associated Microbes of Fungus-Growing Termites
(Project Head
Beemelmanns, Christine
)
WBP Fellowship
Completed projects
Novel actinobacterial TrmD inhibitors to combat Gram-negative pathogens
(Applicant
Bader, Chantal
)
Major Research Instrumentation
Completed projects
500 MHz-NMR-Spectrometer
International Research Training Groups
Completed projects
GRK 532: Physical Methods for the Structural Investigation of New Materials
(Spokesperson
Veith, Michael
)
Clusters of Excellence (ExStra)
Current projects
EXC 2155: RESIST - Resolving Infection Susceptibility
(Spokespersons
Förster, Reinhold
;
Hansen, Gesine
;
Schulz, Thomas
)
