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Institution
Christian-Albrechts-Universität zu Kiel
Medizinische Fakultät
Biochemisches Institut
Address
Olshausenstraße 40
24118 Kiel
Deutschland
GERiT
This institution in GERiT
24118 Kiel
Projects
Research Grants
Current projects
Expanding the Functionality and Target Spectrum of Kinase Inhibitors using PROTACs
(Applicants
Knapp, Stefan
;
Wolf, Elmar
)
Pathophysiologic Role of ADAM10-mediated Podocyte Membrane Protein Proteolysis
(Applicants
Meyer-Schwesinger, Catherine
;
Saftig, Paul
)
Completed projects
Die in vivo Bedeutung lysosomaler Membranproteine bei der intrazellulären Verwertung von Parasiten und Bakterien nach Infektion
(Applicant
Saftig, Paul
)
Functional characterization of the putative lysosomal transporter protein Major facilitator superfamily domain containing 1 (Mfsd1) and its role in sinusoidal obstruction syndrome
(Applicant
Damme, Markus
)
In-vivo-Funktion von LAMP-2
(Applicant
Saftig, Paul
)
Klonierung der Sialat-8-O-Methyltransferase aus dem Seestern Asterias rubens
(Applicant
Shaw, Lee
)
Primary failure of tooth eruption due to heterozygous mutations in the PTH1 receptor gene: Generation and characterization of cell models with clinically relevant mutations and development of therapeutic strategies.
(Applicants
Eigenthaler, Martin
;
Herrmann, Marietta
)
Purification, characterization and cloning of sialate-4-O-acetyltransferase from guinea-pig liver
(Applicant
Schauer, Roland
)
Regulation of cell polarity by control of Sut1-mediated gene expression via the Cdc42 effectors Ste20, Cla4 and Skm1
(Applicant
Rose-John, Stefan
)
senescence and autoimmunity
(Applicant
Rabe, Björn
)
Stimulation of gp130 by membrane bound and soluble interleukin-6-receptor
(Applicant
Rose-John, Stefan
)
Strukturaufklärung des porenbildenden Proteins Amoebapore A von Entamoeba histolytica mit Hilfe der NMR-Spektroskopie
(Applicant
Grötzinger, Joachim
)
The role of gp130-signaling and trans-signaling in liver regeneration and cancer: therapeutic perspectives
(Applicant
Rose-John, Stefan
)
Untersuchungen zum Mechanismus der durch monoklonale IgG-Antikörper maternaler Herkunft induzierten Suppression der IgE-Immunantwort in der Maus
(Applicant
Lemke, Hilmar
)
Untersuchungen zur Funktion des lysosomalen Membranproteins LIMP-II
(Applicant
Saftig, Paul
)
Ursprüngliche cytolytische und antimikrobielle Mechanismen von humanpathogenen und freilebenden Protozoen im Vergleich mit denen höherer Organismen
(Applicant
Leippe, Matthias
)
Independent Junior Research Groups
Completed projects
MYC-dependent co-ordination of RNA polymerase activities during ribosome biogenesis and cell growth
(Applicant
Wolf, Elmar
)
Research Units
Current projects
FOR 2625: Mechanisms of Lysosomal Homeostasis
(Spokesperson
Braulke, Thomas
)
Regulation of TMEM55A/B-dependent positioning of lysosomes
(Applicant
Damme, Markus
)
Understanding the role of the Lysosomal Integral Membrane Protein type 2 (LIMP-2/SCARB2) in lysosomal lipid transport
(Applicant
Saftig, Paul
)
Collaborative Research Centres
Completed projects
Analysis of the role of the shedding protease ADAM 17 in vivo
(Project Heads
Chalaris, Athena
;
Rose-John, Stefan
)
Central Tasks
(Project Head
Rose-John, Stefan
)
Characterization of the in vivo functions of Signal-peptide-peptidase-like 2 intramembrane proteases
(Project Heads
Saftig, Paul
;
Schröder, Bernd
)
Der lösliche Interleukin-6-Rezeptor: Entstehung, Funktion und Anwendung in der Tumortherapie
(Project Head
Rose-John, Stefan
)
Determinants of voltage-gated cation channels as substrates for regulated proteolysis
(Project Heads
Saftig, Paul
;
Schwake, Michael
)
Die Bedeutung der gp 130 Signaltransducers bei immunologischen, inflammatorischen und regeneratorischen Prozessen: Untersuchungen im transgenen Tiermodell
(Project Heads
Peters, Malte
;
Rose-John, Stefan
)
Functions of ADAM metalloproteinases
(Project Heads
Reiss, Karina
;
Saftig, Paul
)
Insights into the cell biology and modulation of ADAM10
(Project Head
Saftig, Paul
)
Integrated Research Training Group
(Project Heads
Becker-Pauly, Christoph
;
Grötzinger, Joachim
;
Leippe, Matthias
;
Pohl, Sandra
)
Proteases and proteolysis followed by microscopy
(Project Heads
Grötzinger, Joachim
;
Saftig, Paul
)
Proteolytic generation of the soluble interleukin-6 receptor in vivo
(Project Heads
Garbers, Christoph
;
Rose-John, Stefan
)
Rekombinante Synthese humaner antimikrobieller Peptide und Proteine
(Project Heads
Grötzinger, Joachim
;
Harder, Jürgen
)
SFB 877: Proteolysis as a Regulatory Event in Pathophysiology
(Spokesperson
Rose-John, Stefan
)
Structure-function analysis of the extracellular part of ADAM 17
(Project Head
Grötzinger, Joachim
)
Strukturaufklärung antimikrobieller Peptide und Proteine mit Hilfe der NMR-Spektroskopie
(Project Head
Grötzinger, Joachim
)
Strukturaufklärung der gp130-Extrazellulärdomänen und des SOCS-1-Proteins mit Hilfe der NMR-Spektroskopie
(Project Head
Grötzinger, Joachim
)
The functions of the gp130-signaling-family for sleep and plasticity
(Project Head
Rose-John, Stefan
)
Therapeutic potential of proteolytically generated prion protein fragments to treat dementia
(Project Heads
Glatzel, Markus
;
Saftig, Paul
)
The role of gp130 signalling during liver regeneration, inflammation and tumour formation: therapeutic perspectives
(Project Heads
Rose-John, Stefan
;
Schmidt-Arras, Dirk
)
The soluble IL6R: Generation and physiological relevance
(Project Heads
Rose-John, Stefan
;
Scheller, Jürgen
)
The structure of Interleukin-27 (p28) and its receptors WSX-1 and EBI-3
(Project Head
Grötzinger, Joachim
)
Virales Interleukin-6: Struktur, Pahtophysiologie und Strategien zu seiner Neutralisierung
(Project Head
Rose-John, Stefan
)
Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization
(Project Head
Rose-John, Stefan
)
Major Research Instrumentation
Completed projects
Laserscanning Mikroscope
Laserscanning-Mikroskop für Live Cell Imaging
Priority Programmes
Completed projects
Lysosomal Membrane Proteins and their Roles in Phagosome Maturation
(Applicants
Haas, Albert
;
Saftig, Paul
)
CRC/Transregios
Current projects
Analyzing and targeting non-catalytic functions of Aurora-A in AML
(Project Heads
Büchel, Gabriele
;
Wolf, Elmar
)
Harnessing novel E3 ligases for cancer-specific degradation of oncogenic targets by PROTACs
(Project Heads
Schindelin, Hermann
;
Wolf, Elmar
)
Research Training Groups
Current projects
GRK 2243: Understanding Ubiquitylation: From Molecular Mechanisms To Disease
(Spokesperson
Buchberger, Alexander
)
Completed projects
GRK 1459: Sorting and Interactions Between Proteins of Subcellular Compartments
(Spokesperson
Braulke, Thomas
)
Clusters of Excellence
Completed projects
EXC 306: Inflammation at Interfaces
(Spokesperson
Schreiber, Stefan
)
Clusters of Excellence (ExStra)
Current projects
EXC 2167: Precision Medicine in Chronic Inflammation (PMI)
(Spokespersons
Niemann, Stefan
;
Riemekasten, Gabriela
;
Schreiber, Stefan
)
Additional Information
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