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Institution
Rheinische Friedrich-Wilhelms-Universität Bonn
Medizinische Fakultät
Institut für Pharmakologie und Toxikologie
Address
Venusberg-Campus 1
53127 Bonn
Deutschland
GERiT
This institution in GERiT
53127 Bonn
Projects
Research Grants
Completed projects
Carrier vermittelte Aufnahme von exogenem Agmatin: (Patho)physiologische und mögliche therapeutische Bedeutung
(Applicant
Molderings, Gerhard J.
)
Entwicklung eines Ansatzes zur Therapie neurodegenerativer Erkrankungen auf Basis von RNA-Interferenz am Beispiel der Prionerkrankungen
(Applicants
Pfeifer, Alexander
;
Walter, Ph.D., Jochen
)
Function of cGMP/PKGI signaling in osteogenic differentiation and disease
(Applicant
Pfeifer, Alexander
)
Identifizierung und molekulare Charakterisierung kationischer Aminosäuretransporter und Untersuchungen zur Regulation ihrer Expression und Bedeutung für die NO Synthese
(Applicant
Racké, Kurt
)
Lentiviral gene transfer into murine embryonic stem cells: Generation of transgenic animals
(Applicant
Pfeifer, Alexander
)
Neurochemische und molekulare Grundlagen der Cannabinoid-Wirkung im Gehirn
(Applicant
Schlicker, Eberhard
)
Neurotransmitter-Systeme als Angriffspunkte selektiver Pharmaka
(Applicant
Göthert, Manfred
)
Regulation der Expression von Arginase I und II in Alveolarmakrophagen und ihre funktionelle Auswirkung für die NO-Synthese
(Applicant
Racké, Kurt
)
Regulation of Activin Receptor-like kinase 7 (ALK7) by cGMP in adipocytes
(Applicant
Pfeifer, Alexander
)
Regulation of skeletal muscle growth and function by the adenosine receptor A2B
(Applicant
Gnad, Thorsten
)
Regulation und funktionelle Bedeutung von Arginase und Arginase-abhängigen Stoffwechselwegen in Atemwegszellen
(Applicant
Racké, Kurt
)
The function of VASP in brown fat
(Applicant
Pfeifer, Alexander
)
Zytoskelettmodulation und zerebrale Ischämie: Effekte von Gelsolin und Cytochalasin D
(Applicant
Fink, Klaus
)
Research Units
Current projects
FOR 5298: iMAGO - Personalized diagnostics for the treatment of obesity
(Spokesperson
Klingenspor, Martin
)
Label-free imaging of lipid-glucose metabolism in cells, tissues, and animals
(Applicants
Li, Yongguo
;
Pleitez Rafael, Ph.D., Miguel Angel
)
Completed projects
Common Resources
(Applicant
Pfeifer, Alexander
)
FOR 917: Nanoparticle-based Delivery of Innovative Therapies (NanoTarget)
(Spokesperson
Pfeifer, Alexander
)
FOR 2372: G protein signalling cascades: with new molecular probes and modulators towards novel pharmacological concepts
(Spokesperson
Kostenis, Evi
)
Function of the endocannabinoid system in normal and pathological ageing processes of the brain
(Applicants
Bilkei-Gorzo, Andras
;
Schlicker, Eberhard
)
Impact of Gq signaling in the brown adipose tissue
(Applicant
Pfeifer, Alexander
)
Magnetic nanoparticles assisted modulation of the vascular cGMP system
(Applicant
Pfeifer, Alexander
)
Modulation of the exocytotic and carrier-mediated transmitter release by endogenous and exogenously added cannabinoids
(Applicant
Schlicker, Eberhard
)
Viral strategies for xenotransplantation
(Applicant
Kupatt, Christian
)
Independent Junior Research Groups
Current projects
Molecular networks and epigenomic mechanisms underpinning white fat browning capacity
(Applicant
Li, Yongguo
)
Collaborative Research Centres
Current projects
The role of cyclic nucleotides in the regulation of adipose tissue resident myeloid cells
(Project Head
Pfeifer, Alexander
)
The spatiotemporal signature of cAMP signaling in brown/beige adipocytes and its interaction with the chemokine-cytokine network
(Project Head
Pfeifer, Alexander
)
Completed projects
Molekulare Charakterisierung antidepressiva-sensitiver Neurotransmitter-Transporter
(Project Head
Bönisch, Heinz
)
Neurotransmitter-Systeme im menschlichen Gehirn als Angriffspunkte selektiver Neuro-Psychopharmaka
(Project Heads
Brüß, Michael
;
Göthert, Manfred
)
Purinerge Neurotransmission
(Project Heads
von Kügelgen, Ivar Constantin
;
Nörenberg, Wolfgang
)
CRC/Transregios
Current projects
Central Tasks
(Project Head
Pfeifer, Alexander
)
ExBat: Effect of acute and chronic exercise on human thermogenic adipose tissue & elucidation of mechanisms
(Project Heads
Soriano-Arroquia, Ph.D., Ana
;
Wackerhage, Henning
)
Extracellular vesicles and regulatory RNAs as intercellular messengers in aortic disease
(Project Heads
Goody, Philip Roger
;
Hosen, Ph.D., Mohammed Rabiul
;
Jansen, Felix
;
Pfeifer, Alexander
)
Functional Proteomics/Metabolomics/Lipidomics and Human Adipocyte Unit
(Project Heads
Dyar, Ph.D., Kenneth A.
;
Meissner, Felix
;
Pfeifer, Alexander
)
Influence of perivascular brown adipose tissue on aortic valve disease
(Project Heads
Hildebrand, Staffan
;
Pfeifer, Alexander
)
Interactions of endothelium and adipocytes during thermogenic adaptation
(Project Heads
Pfeifer, Alexander
;
Wilhelm-Jüngling, Kerstin
)
Purinergic crosstalk in thermogenic fat – Regulation of adenosine release by ENT1
(Project Heads
Gnad, Thorsten
;
Pfeifer, Alexander
)
Regulation and adaptation of G-protein coupled receptors/adenylyl cyclase/cAMP signaling networks in brown/beige AT
(Project Heads
Pfeifer, Alexander
;
Wachten, Dagmar
)
The role of ACTH and glucocorticoid signaling in brown fat metabolism
(Project Heads
Li, Yongguo
;
Uhlenhaut, Nina Henriette
)
TRR 333: Brown and Beige Fat – Organ Crosstalk, Signaling and Energetics (BATenergy)
(Spokesperson
Pfeifer, Alexander
)
Research Training Groups
Completed projects
GRK 246: Pathogenesis of Diseases of the Central Nervous System
(Spokesperson
Propping, Peter
)
GRK 1873: Pharmacology of 7TM-Receptors and Downstream Signalling Pathways
(Spokesperson
Pfeifer, Alexander
)
Additional Information
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