Angiotensin stimulated hepatic fibrogenesis and portal hypertension: Receptor regulation and intracellular signaling ((3)-P18)

• Subject Area: Gastroenterology
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 36842431

The aim of this project is to decrease hepatic fibrosis and portal pressure via modulation of the renin-angiotensin-system (RAS) and the linked downstream intracellular pathways. This project will evaluate the role of further members of RAS, namely the enzyme neprilysin (NEP), and the receptors AT2R and MrgD in experimental liver fibrosis. To this end we will use genetically modified mice deficient for NEP, AT2R and MrgD, as well as a mouse model of continuous stimulation and inhibition of NEP, AT2R and MrgD-receptor. Upon induction of fibrosis, we will characterize the development of fibrosis and portal hypertension in vitro and in vivo, with special emphasis on signalling molecules to define novel targets and develop new therapies.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 57: Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Dr. Tilman Sauerbruch, until 12/2016; Professor Jonel Trebicka, Ph.D.