Inflammatory and cell-death-related pathways in liver fibrosis: Cell-type specific approaches to novel therapies ((1)-P06)

• Subject Area: Gastroenterology
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 36842431

The kinase RIPK3 regulates a novel form of programmed cell death called 'necroptosis' and other signaling pathways involved in cell death and inflammation. In the 2nd funding period, we could demonstrate that RIPK3 is overexpressed in human non-alcoholic steatohepatitis (NASH) and mediates NASH fibrosis in mice. In the 3rd funding period, P06 will therefore further elaborate the molecular targets of RIPK3 in NASH fibrosis and will put a major focus on translational aspects. Moreover, the project will investigate the important question if induction of programmed cell death in HSC via apoptosis (Caspase-dependent) or necroptosis (RIPK3-dependent) can prevent fibrosis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 57: Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Tom Lüdde, Ph.D.; Professor Dr. Christian Trautwein