Project Details
Projekt
Molecular control of cell migration during Xenopus gastrulation by different Wnt signaling pathways
Applicant
Professorin Dr. Doris Wedlich (†)
Subject Area
Developmental Biology
Term
from 2009 to 2015
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 58160712
Convergent extension (CE) movements of the dorsal mesoderm make a major contribution to shaping the dorsal body axis of vertebrate embryos. In our previous research we have identified the protocadherin XPAPC as a key molecule that is regulated by the Wnt-5A/Ror2 signaling cascade and interacts with the Wnt/PCP pathway to coordinate CE movements in Xenopus laevis. Our future research will focus on (1) further characterization of the novel Wnt-5A/Ror2 pathway, including identification of additional effector proteins, (2) the functional and molecular interconnection of both non-canonical Wnt-signaling pathways and (3) on their evolutionary conservation. The latter is a novel aspect that arises by the integration into the research unit. By interspecies functional studies the conservation of the physiological role of Wnt-5a/Ror2 and Wnt/PCP pathways will be addressed in processes of Hydra regeneration and mouse myocardial remodeling.
DFG Programme
Research Units
