GRK 1208:  Hormonal Regulation of Energy Metabolism, Body Weight and Growth

• Subject Area: Medicine
• Term: from 2005 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 823482

• Final Report Year: 2015

Final Report Abstract

Hormonal regulation of body weight, energy metabolism and growth represent a key research area in medicine in the context of the current pandemia of obesity in children, adolescents, and adults, which is associated with major non-communicable diseases such as diabetes, metabolic syndrome and hypertension with increasing frequencies even in developing countries. In order to develop new preventive and therapeutic strategies a new generation of researchers with a special interest in this emerging topic, who are capable to fully understand the complex and redundant endocrine regulation, has to be educated. The investigator teams of this DFG-funded graduate programme have allied to study hormonal mechanisms of action, modes of metabolic adaptation to these conditions and interactions between endocrine and metabolic pathways involved in the homeostatic regulation of body weight, energy metabolism and growth. Specifically, the role of glucoregulatory hormones, the growth hormone-IGF1 system, thyroid hormones and thyronamines as well as the contribution of novel adipokines and cytokines have been investigated. The research included mechanistic, genetic and epigenetic studies, analysis of receptors and signaling cascades involved in this communication network, cellular and animal models as well as clinical interventional human studies. The interdisciplinary and translational research program was combined with a research-oriented training curriculum which intended providing deeper insights into pathogenic mechanisms and developments associated with ‘diabesity’. Thesis students have been qualified to successfully perform in competitive life science research, for successful careers in academia or health-research oriented organizations and related industry. Competitive recruitment of scholarship holders and associate members of the graduate programme attracted students of various life science areas including medical students and also international applicants. Most of the students published their research work either as first or coauthors of peer reviewed papers, some of them have several publications. A major achievement of this graduate programme was the intensification and expansion of the research network in the hormone and metabolism area between participating teams of the network. This was frequently stimulated by a bottom-up cooperative approach initiated between the students working on their thesis project, which then resulted in closer interactions, joint publications and successful grant proposals by the PIs, mentors and tutors contributing to the programme. To name two examples: the DFG-funded Clinical Research Group 218 ‘Maintain’ and the DFG-funded Priority Program SPP1629 ‘ThyroidTransAct’, both of which were initiated and significantly stimulated on the basis of the productive interactions and novel findings generated by the graduate programme. Beyond that, the two DFG funding periods resulted in a strong and sustainable consolidation of basic, translational and clinical research networks as well as academic institutions in the Berlin-Potsdam area but also in high motivation and recruitment of young researchers to the research topics of the graduate programme. This is illustrated by several of the alumni attracting already their own research grants, successfully applying for funding or taking positions as junior group leaders similar to several of the former or current mentors and tutors who contributed to the curriculum during both funding periods. The interdisciplinary and network-oriented approach also established several strong international links and cooperations significantly stimulated by novel teaching formats (e.g. tandem and mentor lectures or repetitorium) and the highly attractive and successful ‘International Guest Lecture Series’ of this programme, which attracted leading scientists for lectures and seminars and to closely interact with the thesis students.

Publications

• Altered apolipoprotein A-V expression during the acute phase response is independent of plasma triglyceride levels in mice and humans. Biochem Biophys Res Commun. 2006 Jan 20;339(3):833-9
  Becker S, Schomburg L, Renko K, Tölle M, van der Giet M, Tietge UJ
  
• Enhancement of long-term potentiation at CA1-subiculum synapses in MK-801-treated rats. Neurosci Lett. 2006 Jan 9;392(1-2):5-9
  Buck N, Cali S, Behr J
  
• Effect of age on sexually dimorphic selenoprotein expression in mice. Biol Chem. 2007 Oct;388(10):1035-41
  Schomburg L, Riese C, Renko K, Schweizer U
  
• 2008: Hormonal regulation of glucose transport and whole-body glucose homeostasis, Potsdam, Univ., Diss., 2009
  Chadt, Alexandra
  
• A heterozygous mutation in the third transmembrane domain causes a dominant-negative effect on signalling capability of the MC4R. Obes Facts. 2008;1(3):155-62
  Tarnow P, Rediger A, Brumm H, Ambrugger P, Rettenbacher E, Widhalm K, Hinney A, Kleinau G, Schaefer M, Hebebrand J, Krause G, Grüters A, Biebermann H
  (See online at https://doi.org/10.1159/000138251)
• Charakterisierung von Interaktionen G-Protein gekoppelter Rezeptoren der hypothalamischen Gewichtsregulation , Berlin, Humboldt-Univ., Diss., 2008
  Rediger, Anne
  
• Deletion of glucose transporter GLUT8 in mice increases locomotor activity. Behav Genet. 2008 Jul;38(4):396-406
  Schmidt S, Gawlik V, Hölter SM, Augustin R, Scheepers A, Behrens M, Wurst W, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Kluge R, Joost HG, Schürmann A
  (See online at https://doi.org/10.1007/s10519-008-9208-1)
• Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice. Biochem J. 2008 Feb 1;409(3):741-9
  Renko K, Werner M, Renner-Müller I, Cooper TG, Yeung CH, Hollenbach B, Scharpf M, Köhrle J, Schomburg L, Schweizer U
  
• High-fat, carbohydrate-free diet markedly aggravates obesity but prevents beta-cell loss and diabetes in the obese, diabetes-susceptible db/db strain. Obes Facts. 2008;1(6):292-7
  Mirhashemi F, Kluth O, Scherneck S, Vogel H, Kluge R, Schurmann A, Joost HG, Neschen S
  (See online at https://doi.org/10.1159/000176064)
• Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice. Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1084-94
  Schmidt S, Richter M, Montag D, Sartorius T, Gawlik V, Hennige AM, Scherneck S, Himmelbauer H, Lutz SZ, Augustin R, Kluge R, Ruth P, Joost HG, Schürmann A
  (See online at https://doi.org/10.1152/ajpendo.90491.2008)
• Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa. Mol Membr Biol. 2008 Apr;25(3):224-35
  Gawlik V, Schmidt S, Scheepers A, Wennemuth G, Augustin R, Aumüller G, Moser M, Al-Hasani H, Kluge R, Joost HG, Schürmann A
  (See online at https://doi.org/10.1080/09687680701855405)
• Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity. Nat Genet. 2008 Nov;40(11):1354-9
  Chadt A, Leicht K, Deshmukh A, Jiang LQ, Scherneck S, Bernhardt U, Dreja T, Vogel H, Schmolz K, Kluge R, Zierath JR, Hultschig C, Hoeben RC, Schürmann A, Joost HG, Al-Hasani H
  (See online at https://doi.org/10.1038/ng.244)
• The roles of deiodinases in thyronamine biology Berlin, Humboldt-Univ., Diss., 2008
  Piehl, Susanne
  
• Bedeutung und Regulation der Biosynthese von Selenoproteinen beim Wachstum und der Akut-Phase-Reaktion der Maus, Berlin, Techn. Univ., Diss., 2009
  Renko, Kostja
  
• Birth weight, early weight gain, and subsequent risk of type 1 diabetes: systematic review and meta-analysis. Am J Epidemiol. 2009 Jun 15;169(12):1428-36
  Harder T, Roepke K, Diller N, Stechling Y, Dudenhausen JW, Plagemann A
  (See online at https://doi.org/10.1093/aje/kwp065)
• Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expr Patterns. 2009 Apr;9(4):215-23
  Witte F, Dokas J, Neuendorf F, Mundlos S, Stricker S
  (See online at https://doi.org/10.1016/j.gep.2008.12.009)
• CXCL13 expression in the gut promotes accumulation of IL-22-producing lymphoid tissue-inducer cells, and formation of isolated lymphoid follicles. Mucosal Immunol. 2009 Nov;2(6):486-94
  Marchesi F, Martin AP, Thirunarayanan N, Devany E, Mayer L, Grisotto MG, Furtado GC, Lira SA
  (See online at https://doi.org/10.1038/mi.2009.113)
• Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice. FASEB J. 2009 Jun;23(6):1758-65
  Renko K, Hofmann PJ, Stoedter M, Hollenbach B, Behrends T, Köhrle J, Schweizer U, Schomburg L
  (See online at https://doi.org/10.1096/fj.08-119370)
• Essential role of glucose transporter GLUT3 for post-implantation embryonic development. J Endocrinol. 2009 Jan;200(1):23-33
  Schmidt S, Hommel A, Gawlik V, Augustin R, Junicke N, Florian S, Richter M, Walther DJ, Montag D, Joost HG, Schürmann A
  (See online at https://doi.org/10.1677/JOE-08-0262)
• Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21. Diabetes. 2009 Jul;58(7):1532-8
  Mai K, Andres J, Biedasek K, Weicht J, Bobbert T, Sabath M, Meinus S, Reinecke F, Möhlig M, Weickert MO, Clemenz M, Pfeiffer AF, Kintscher U, Spuler S, Spranger J
  (See online at https://doi.org/10.2337/db08-1775)
• Heterodimerization of hypothalamic G-protein-coupled receptors involved in weight regulation. Obes Facts. 2009;2(2):80-6
  Rediger A, Tarnow P, Bickenbach A, Schaefer M, Krude H, Gruters A, Biebermann H
  (See online at https://doi.org/10.1159/000209862)
• High energy digestion efficiency and altered lipid metabolism contribute to obesity in BFMI mice. Obesity (Silver Spring). 2009 Nov;17(11):1988-93
  Meyer CW, Wagener A, Rink N, Hantschel C, Heldmaier G, Klingenspor M, Brockmann GA
  (See online at https://doi.org/10.1038/oby.2009.124)
• Hormonal adaptation to metabolic changes as result of selection and excessive energy supply in a Berlin Fat Mouse Inbred line, (Berlin, Humboldt-Univ., Diss., 2009
  Hesse (geb. Hantschel), Claudia
  
• Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J Physiol. 2009 Oct 15;587(Pt 20):4963-76
  Plagemann A, Harder T, Brunn M, Harder A, Roepke K, Wittrock-Staar M, Ziska T, Schellong K, Rodekamp E, Melchior K, Dudenhausen JW
  (See online at https://doi.org/10.1113/jphysiol.2009.176156)
• Lysosomal localization of GLUT8 in the testis--the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction. FEBS J. 2009 Jul;276(14):3729-43
  Diril MK, Schmidt S, Krauss M, Gawlik V, Joost HG, Schürmann A, Haucke V, Augustin R
  (See online at https://doi.org/10.1111/j.1742-4658.2009.07089.x)
• Role of the glucose transporter GLUT8 for glucose homeostasis, sperm motility and behavior (Potsdam, Univ., Diss., 2009)
  Behrens (geb. Gawlik), Verena
  
• A New Phenotype of Nongoitrous and Nonautoimmune hyperthyroidism Caused by a Heterozygous Thyrotropin Receptor Mutation in Transmembrane Helix 6. J Clin Endocrinol Metab. 2010 Aug;95(8):3605-10
  Winkler F, Kleinau G, Tarnow P, Rediger A, Grohmann L, Gaetjens I, Krause G, Grüters A, Krude H, Biebermann H
  
• A unique genetic defect on chromosome 3 is responsible for juvenile obesity in the Berlin Fat Mouse. Int J Obes (Lond). 2010 Dec;34(12):1706-14
  Neuschl C, Hantschel C, Wagener A, Schmitt AO, Illig T, Brockmann GA
  (See online at https://doi.org/10.1038/ijo.2010.97)
• ACBP knockdown leads to downregulation of genes encoding rate-limiting enzymes in cholesterol and fatty acid metabolism. Cell Physiol Biochem. 2010;25(6):675-86
  Vock C, Biedasek K, Boomgaarden I, Heins A, Nitz I, Döring F
  (See online at https://doi.org/10.1159/000315087)
• Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin. Eur J Endocrinol. 2010 Aug;163(2):259-64
  Sauber J, Grothe J, Behm M, Scherag A, Grallert H, Illig T, Hinney A, Hebebrand J, Wiegand S, Grüters A, Krude H, Biebermann H
  (See online at https://doi.org/10.1530/EJE-10-0444)
• Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture. J Nutr Biochem. 2011 Oct;22(10):945-55
  Hoefig CS, Renko K, Köhrle J, Birringer M, Schomburg L
  (See online at https://doi.org/10.1016/j.jnutbio.2010.08.006)
• Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure. Diabetologia. 2011 Mar;54(3):605-16
  Kluth O, Mirhashemi F, Scherneck S, Kaiser D, Kluge R, Neschen S, Joost HG, Schürmann A
  (See online at https://doi.org/10.1007/s00125-010-1973-8)
• Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding. J Perinat Med. 2010 Jul;38(4):393-400
  Plagemann A, Roepke K, Harder T, Brunn M, Harder A, Wittrock-Staar M, Ziska T, Schellong K, Rodekamp E, Melchior K, Dudenhausen JW
  (See online at https://doi.org/10.1515/jpm.2010.051)
• Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8. J Biol Chem. 2010 Sep 3;285(36):28054-63
  Kinne A, Kleinau G, Hoefig CS, Grüters A, Köhrle J, Krause G, Schweizer U
  (See online at https://doi.org/10.1074/jbc.M110.129577)
• High-fat diet leads to tissue-specific changes reflecting risk factors for diseases in DBA/2J mice. Physiol Genomics. 2010 Jun;42(1):55-66
  Hageman RS, Wagener A, Hantschel C, Svenson KL, Churchill GA, Brockmann GA
  (See online at https://doi.org/10.1152/physiolgenomics.00072.2009)
• Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus. PLoS One. 2010 Nov 15;5(11):e13967
  Scherag A, Jarick I, Grothe J, Biebermann H, Scherag S, Volckmar AL, Vogel CI, Greene B, Hebebrand J, Hinney A
  (See online at https://doi.org/10.1371/journal.pone.0013967)
• Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin. Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E126-30
  Mai K, Bobbert T, Groth C, Assmann A, Meinus S, Kraatz J, Andres J, Arafat AM, Pfeiffer AF, Möhlig M, Spranger J
  (See online at https://doi.org/10.1152/ajpendo.00020.2010)
• Selenium controls the sex-specific immune response and selenoprotein expression during the acute-phase response in mice. Biochem J. 2010 Jul 1;429(1):43-51
  Stoedter M, Renko K, Hög A, Schomburg L
  (See online at https://doi.org/10.1042/BJ20091868)
• Specific monoclonal antibodies and ultrasensitive immunoassays for 20K and 22K human growth hormone. Growth Horm IGF Res. 2010 Jun;20(3):239-44
  Wu Z, Devany E, Balarini G, Junnila R, Bidlingmaier M, Strasburger CJ
  (See online at https://doi.org/10.1016/j.ghir.2010.02.006)
• The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis. Mol Cell Biol. 2010 Mar;30(5):1231-42
  Hommel A, Hesse D, Völker W, Jaschke A, Moser M, Engel T, Blüher M, Zahn C, Chadt A, Ruschke K, Vogel H, Kluge R, Robenek H, Joost HG, Schürmann A
  (See online at https://doi.org/10.1128/MCB.01269-09)
• Thyroid hormones regulate selenoprotein expression and selenium status in mice. PLoS One. 2010 Sep 22;5(9):e12931
  Mittag J, Behrends T, Hoefig CS, Vennström B, Schomburg L
  (See online at https://doi.org/10.1371/journal.pone.0012931)
• Untersuchung der Allelfrequenz dreier SNPs bei adipösen Kindern aus dem Raum Berlin, Berlin, Charité, Univ.-Med., Diss., 2010
  Sauber, Jeannine
  
• (2011): Growth hormone receptor antagonist: a recombinant bispecific antibody. Summer school of endocrinology, Bregenz, Austria
  Götsch F, Wu Z, Strasburger C J
  
• Biomarker discovery and redundancy reduction towards classification using a multi-factorial MALDI-TOF MS T2DM mouse model dataset. BMC Bioinformatics. 2011 May 9;12:140
  Bauer C, Kleinjung F, Smith CJ, Towers MW, Tiss A, Chadt A, Dreja T, Beule D, Al-Hasani H, Reinert K, Schuchhardt J, Cramer R
  (See online at https://doi.org/10.1186/1471-2105-12-140)
• Body weight and energy homeostasis was not affected in C57BL/6 mice fed high whey protein or leucine-supplemented low-fat diets. Eur J Nutr. 2011 Sep;50(6):479-88
  Noatsch A, Petzke KJ, Millrose MK, Klaus S
  (See online at https://doi.org/10.1007/s00394-010-0155-2)
• Determinants of selenium status in healthy adults. Nutr J. 2011 Jul 18;10:75
  Combs GF Jr, Watts JC, Jackson MI, Johnson LK, Zeng H, Scheett AJ, Uthus EO, Schomburg L, Hoeg A, Hoefig CS, Davis CD, Milner JA
  (See online at https://doi.org/10.1186/1475-2891-10-75)
• Diet dependence of diabetes in the New Zealand Obese (NZO) mouse: total fat, but not fat quality or sucrose accelerates and aggravates diabetes. Exp Clin Endocrinol Diabetes. 2011 Mar;119(3):167-71
  Mirhashemi F, Scherneck S, Kluth O, Kaiser D, Vogel H, Kluge R, Schürmann A, Neschen S, Joost HG
  (See online at https://doi.org/10.1055/s-0030-1263127)
• Differential Modulation of Beta-Adrenergic Receptor Signaling by Trace Amine- Associated Receptor 1 Agonists. 2011: PLoS One. 6(10):e27073
  Kleinau G, Pratzka J, Nürnberg D, Grüters A, Führer-Sakel D, Krude H, Köhrle J, Schöneberg T, Biebermann H
  
• Evidence for extrathyroidal formation of 3-iodothyronamine in humans as provided by a novel monoclonal antibody-based chemiluminescent serum immunoassay. J Clin Endocrinol Metab. 2011 Jun;96(6):1864-72
  Hoefig CS, Köhrle J, Brabant G, Dixit K, Yap B, Strasburger CJ, Wu Z
  (See online at https://doi.org/10.1210/jc.2010-2680)
• Features of the metabolic syndrome in the Berlin Fat Mouse as a model for human obesity. ObesFacts. 2011;4(4):270-7
  Hantschel C, Wagener A, Neuschl C, Teupser D, Brockmann GA
  (See online at https://doi.org/10.1159/000330819)
• Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids. Diabetes. 2012 Feb;61(2):292-300
  Gögebakan Ö, Andres J, Biedasek K, Mai K, Kühnen P, Krude H, Isken F, Rudovich N, Osterhoff MA, Kintscher U, Nauck M, Pfeiffer AF, Spranger J
  (See online at https://doi.org/10.2337/db10-0902)
• IGF-I contributes to glucose homeostasis in the Berlin Fat Mouse Inbred line. Growth Factors. 2011 Dec;29(6):298-309
  Schäfer N, Wagener A, Hantschel C, Mauel S, Gruber AD, Brockmann GA
  (See online at https://doi.org/10.3109/08977194.2011.625026)
• In Vitro Characterization of Human Growth Hormone Mutants Berlin, Humboldt Universität zu Berlin, Diss., 2011
  Sustarsic (geb. Junnila), Riia
  
• Komplexe Genetik des Diabetes mellitus am Beispiel der Maus. BIOspektrum (2011) 17: 402-404
  Neumann F, Dokas J, Al-Hasani H
  
• Methylierungsstudien am MC4R und POMC, Berlin, Humboldt Universität zu Berlin, Diss., 2011
  Mischke, Mona
  
• Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors. J Biol Chem. 2011 Nov 11;286(45):39623-31
  Rediger A, Piechowski CL, Yi CX, Tarnow P, Strotmann R, Grüters A, Krude H, Schöneberg T, Tschöp MH, Kleinau G, Biebermann H
  (See online at https://doi.org/10.1074/jbc.M111.287607)
• New Thyrotropin receptor germline mutation Ile486Asn in extracellular loop 1 causes constitutive activity of the Gαs- cAMP but the Gαq- IP3 cascade. Thyroid Research 2011, 4(Suppl 1):S8
  Biebermann H, Winkler F, Handke D, Grüters A, Krude H, Kleinau G
  
• p53 inhibits mRNA 3' processing through its interaction with the CstF/BARD1 complex. Oncogene. 2011 Jul 7;30(27):3073-83
  Nazeer FI, Devany E, Mohammed S, Fonseca D, Akukwe B, Taveras C, Kleiman FE
  (See online at https://doi.org/10.1038/onc.2011.29)
• Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2. J Biol Chem. 2011 Dec 9;286(49):42188-99
  Miranda DA, Koves TR, Gross DA, Chadt A, Al-Hasani H, Cline GW, Schwartz GJ, Muoio DM, Silver DL
  (See online at https://doi.org/10.1074/jbc.M111.297127)
• Skeletal muscle 11beta-HSD1 controls glucocorticoid-induced proteolysis and expression of E3 ubiquitin ligases atrogin-1 and MuRF- 1. PLoS One. 2011 Jan 31;6(1):e16674
  Biedasek K, Andres J, Mai K, Adams S, Spuler S, Fielitz J, Spranger J
  (See online at https://doi.org/10.1371/journal.pone.0016674)
• The growth hormone--IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania. Int J Obes (Lond). 2011 Mar;35(3):364-72
  Rosskopf D, Schwahn C, Neumann F, Bornhorst A, Rimmbach C, Mischke M, Wolf S, Geissler I, Kocher T, Grabe HJ, Nauck M, Hebebrand J, Kroemer HK, Friedrich N, Völzke H, Wallaschofski H
  (See online at https://doi.org/10.1038/ijo.2010.158)
• The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1. J Cell Biol. 2011 Feb 21;192(4):583-98
  Kurischko C, Kim HK, Kuravi VK, Pratzka J, Luca FC
  (See online at https://doi.org/10.1083/jcb.201011061)
• Thyronamines - past, present, and future. Endocr Rev. 2011 Feb;32(1):64-80
  Piehl S, Hoefig CS, Scanlan TS, Köhrle J
  (See online at https://doi.org/10.1210/er.2009-0040)
• “Molecular description of nonautoimmune hyperthyroidism at a neonate caused by a new thyrotropin receptor germline mutation.” Thyroid Res. 2011 Aug 3;4 Suppl 1:S8
  Biebermann H, Winkler F, Handke D, Grüters A, Krude H, Kleinau G
  (See online at https://doi.org/10.1186/1756-6614-4-S1-S8)
• “New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR” J Clin Endocrinol Metab. 2012 Feb;97(2):E228-32
  Biebermann H, Winkler F, Handke D, Teichmann A, Gerling B, Cameron F, Eichhorst J, Grüters A, Wiesner B, Kühnen P, Krude H, Kleinau G
  (See online at https://doi.org/10.1210/jc.2011-2106)
• (2012): Development of a new growth hormone receptor antagonist. 6th international congress of the GRS and IGF society. Munich, Germany
  Götsch F, Wu Z, Strasburger C J
  
• (2012): Immunological role of vitamin D in kidney. Summer school of endocrinology. Bregenz, Austria
  Götsch F, Strasburger C J, Quinkler M
  
• 2012: Establishment of detection methods to study the biosynthesis of thyronamines, Berlin, Humboldt-Univ., Diss., 2012
  Höfig, Carolin
  
• Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally. PLoS One. 012;7(10):e47776
  Schellong K, Schulz S, Harder T, Plagemann A
  (See online at https://doi.org/10.1371/journal.pone.0047776)
• Differential responses to selenomethionine supplementation by sex and genotype in healthy adults. Br J Nutr. 2012 May;107(10):1514-25
  Combs GF Jr, Jackson MI, Watts JC, Johnson LK, Zeng H, Idso J, Schomburg L,Hoeg A, Hoefig CS, Chiang EC, Waters DJ, Davis CD, Milner JA
  (See online at https://doi.org/10.1017/S0007114511004715)
• Do common variants separate between obese melanocortin-4 receptor gene mutation carriers and noncarriers? The impact of cryptic relatedness. Horm Res Paediatr. 2012;77(6):358-68
  Mühlhaus J, Pütter C, Brumm H, Grallert H, Illig T, Scherag S, Reinehr T, Pott W, Albayrak Ö, Wang HJ, Bau AM, Wiegand S, Grüters A, Krude H, Hebebrand J, Hinney A, Biebermann H, Scherag A
  (See online at https://doi.org/10.1159/000338999)
• Early postnatal life as a critical time window for determination of long-term metabolic health. Best Pract Res Clin Endocrinol Metab. 2012 Oct;26(5):641-53
  Plagemann A, Harder T, Schellong K, Schulz S, Stupin JH
  (See online at https://doi.org/10.1016/j.beem.2012.03.008)
• Identification of the translation start site of the human melanocortin 3 receptor. Obes Facts. 2012;5(1):45-51
  Tarnow P, Rediger A, Schulz A, Grüters A, Biebermann H
  (See online at https://doi.org/10.1159/000336070)
• Insulin stimulates fusion, but not tethering, of GLUT4 vesicles in skeletal muscle of HA- GLUT4-GFP transgenic mice. Am J Physiol Endocrinol Metab. 2012 Apr 15;302(8):E950-60
  Lizunov VA, Stenkula KG, Lisinski I, Gavrilova O, Yver DR, Chadt A, Al-Hasani H, Zimmerberg J, Cushman SW
  (See online at https://doi.org/10.1152/ajpendo.00466.2011)
• Metformin inhibits growth of thyroid carcinoma cells, suppresses self-renewal of derived cancer stem cells, and potentiates the effect of chemotherapeutic agents. J Clin Endocrinol Metab. 2012 Apr;97(4):E510-20
  Chen G, Xu S, Renko K, Derwahl M
  (See online at https://doi.org/10.1210/jc.2011-1754)
• Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state Proc Natl Acad Sci USA. 2012 Jan 31;109(5):1518-23
  Mergenthaler P(1), Kahl A, Kamitz A, van Laak V, Stohlmann K, Thomsen S, Klawitter H, Przesdzing I, Neeb L, Freyer D, Priller J, Collins TJ, Megow D, Dirnagl U, Andrews DW, Meisel A
  (See online at https://doi.org/10.1073/pnas.1108225109)
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