GRK 1172:  Erforschung, Entwicklung und Sicherheit von Biopharmazeutika

Zusammenfassung der Projektergebnisse

Das Graduiertenkolleg hat eine herausragende Bedeutung für die nationale und internationale wissenschaftliche Sichtbarkeit des Standortes im Bereich der modernen Pharmaentwicklung. Es initiierte und stabilisierte eine langjährige enge Zusammenarbeit innerhalb der Fachbereiche der Goethe-Universität sowie mit den außeruniversitären Institutionen Georg-Speyer Haus, Blutspendedienst und dem Paul-Ehrlich-Institut Langen. Ein wenig aufwendiger war die Kooperation mit der Firma Merck KGaA aufgrund der mehrfachen Umorientierung der wissenschaftlichen Schwerpunkte und der damit verbundenen finanziellen Limitierungen. Die Attraktivität der weiter unten ausgeführten Graduiertenausbildung aber auch die Plattform für einen wissenschaftlichen Austausch führte zu einem großen Interesse auch nicht beteiligter Wissenschaftler, ihre PhD Studenten zu assoziieren. Diese Einbindung von 25 PhD Studenten gelang und war sicher einer der großen Erfolge des GRK. Darüber hinaus bauten einige PhD Studenten internationale Verbindungen mit z.B. dem Karolinska in Stockholm, dem NIH und einigen weiteren Institutionen auf. Obwohl eine genaue Quantifizierung der Zahl unabhängiger Publikationen und des genauen Impacts aufgrund der Beteiligung von mehreren PhD Studenten an gleichen Publikationen schwierig bleibt, resultierten doch etwa 3-4 Erst-/Koautorenschaften pro Doktorand im naturwissenschaftlichen Bereich und beeindruckende, mehr als 300 Originalarbeiten in ausgewiesenen internationalen Journalen.

Projektbezogene Publikationen (Auswahl)

• HIV-1 Vif: HIV’s weapon against the cellular defense factor APOBEC3G. Curr HIV Res. 2005 Oct;3(4):339-44
  Kremer M, Schnierle BS
  
• Human APOBEC3G incorporation into murine leukemia virus particles. Virology. 2005 Jun 20;337(1):175-82
  Kremer M, Bittner A, Schnierle BS
  
• Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris. Biochem J. 2006 Mar 15;394(Pt 3):563-73
  Giesübel U, Dälken B, Mahmud H, Wels WS
  
• Oncostatin M expression is functionally connected to neutrophils in the early inflammatory phase of skin repair: implications for normal and diabetes-impaired wounds. J Invest Dermatol. 2006 Mar;126(3):628-37
  Goren I, Kämpfer H, Müller E, Schiefelbein D, Pfeilschifter J, Frank S
  
• Vaccinia virus replication is not affected by APOBEC3 family members. Virol J. 2006 Oct 19;3:86
  Kremer M, Suezer Y, Martinez-Fernandez Y, Münk C, Sutter G, Schnierle BS
  
• A novel five-colour flow cytometric assay to determine NK cell cytotoxicity against neuroblastoma and other adherent tumour cells. J Immunol Methods. 2007 Aug 31;325(1-2):140-7
  Klöss S, Bochennek K, Huenecke S, Zimmermann SY, Kuçi S, Müller T, Wels WS, Klingebiel T, Esser R, Koehl U
  
• Impact of viral accessory proteins of SIVsmmPBj on early steps of infection of quiescent cells. Virology. 2007 Aug 1;364(2):330-41
  Wolfrum N, Muehlebach MD, Schüle S, Kaiser JK, Kloke BP, Cichutek K, Schweizer M
  
• Multiple restrictions of human immunodeficiency virus type 1 in feline cells. J Virol. 2007 Jul;81(13):7048-60
  Münk C, Zielonka J, Constabel H, Kloke BP, Rengstl B, Battenberg M, Bonci F, Pistello M, Löchelt M, Cichutek K
  
• Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages. J Invest Dermatol. 2007 Sep;127(9):2259-67
  Goren I, Müller E, Schiefelbein D, Christen U, Pfeilschifter J, Mühl H, Frank S
  
• The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells. J Biol Chem. 2007 Jun 1;282(22):16006-15
  Ziesché E, Bachmann M, Kleinert H, Pfeilschifter J, Mühl H
  
• [Non-viral gene transfer results in therapeutic factor IX levels in haemophilia B mice]. Hamostaseologie. 2008 Oct;28 Suppl 1:S92-5. German
  Schüttrumpf J, Milanov P, Roth S, Seifried E, Tonn T
  
• Age-matched lymphocyte subpopulation reference values in childhood and adolescence: application of exponential regression analysis. Eur J Haematol. 2008 Jun;80(6):532-9
  Huenecke S, Behl M, Fadler C, Zimmermann SY, Bochennek K, Tramsen L, Esser R, Klarmann D, Kamper M, Sattler A, von Laer D, Klingebiel T, Lehrnbecher T, Koehl U
  
• Antitumour effects in mycosis fungoides of the immunomodulatory, tellurium-based compound, AS101. Br J Dermatol. 2008 Mar;158(3):578-86
  Frei GM, Kremer M, Hanschmann KM, Krause S, Albeck M, Sredni B, Schnierle BS
  
• Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses. J Biol Chem. 2008 May 30;283(22):15479-90
  Schiefelbein D, Goren I, Fisslthaler B, Schmidt H, Geisslinger G, Pfeilschifter J, Frank S
  
• Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase: implications for diabetes-impaired skin repair. Mol Pharmacol. 2008 Oct;74(4):952-63
  Schiefelbein D, Seitz O, Goren I, Dissmann JP, Schmidt H, Bachmann M, Sader R, Geisslinger G, Pfeilschifter J, Frank S
  
• Retroviral display and high throughput screening. Comb Chem High Throughput Screen. 2008 Feb;11(2):99-110
  Buchholz CJ, Duerner LJ, Funke S, Schneider IC
  
• T cells for suicide gene therapy: activation, functionality and clinical relevance. J Immunol Methods. 2008 Feb 29;331(1-2):69-81
  Hollatz G, Grez M, Mastaglio S, Quaritsch R, Huenecke S, Ciceri F, Bonini C, Esser R, Klingebiel T, Kreuter J, Koehl U
  
• Targeted cell entry of lentiviral vectors. Mol Ther. 2008 Aug;16(8):1427-36
  Funke S, Maisner A, Muehlebach MD, Koehl U, Grez M, Cattaneo R, Cichutek K, Buchholz CJ
  
• Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. J Invest Dermatol. 2009 Mar;129(3):752-64
  Goren I, Müller E, Schiefelbein D, Gutwein P, Seitz O, Pfeilschifter J, Frank S
  
• An RNA aptamer that induces transcription. Chem Biol. 2009 Feb 27;16(2):173-80
  Hunsicker A, Steber M, Mayer G, Meitert J, Klotzsche M, Blind M, Hillen W, Berens C, Suess B
  
• Cofilin phosphorylation is involved in nitric oxide/cGMP-mediated nociception. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1408-13
  Zulauf L, Coste O, Marian C, Möser C, Brenneis C, Niederberger E
  
• Computer-aided analysis of cell interactions under dynamic flow conditions. Exp Dermatol. 2009 Mar;18(3):238-45. Erratum in: Exp Dermatol. 2009 Dec;18(12):1096
  Giegold O, Ludwig RJ, Hardt K, Will J, Schön MP, Oostingh GJ, Pfeilschifter JM, Boehncke WH, Radeke HH
  
• CXCL16 and oxLDL are induced in the onset of diabetic nephropathy. J Cell Mol Med. 2009 Sep;13(9B):3809-25
  Gutwein P, Abdel-Bakky MS, Doberstein K, Schramme A, Beckmann J, Schaefer L, Amann K, Doller A, Kämpfer- Kolb N, Abdel-Aziz AA, El Sayed el SM, Pfeilschifter J
  
• CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein. Am J Pathol. 2009 Jun;174(6):2061-72
  Gutwein P, Abdel-Bakky MS, Schramme A, Doberstein K, Kämpfer-Kolb N, Amann K, Hauser IA, Obermüller N, Bartel C, Abdel-Aziz AA, El Sayed el SM, Pfeilschifter J
  
• Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Clin Exp Immunol. 2009 Sep;157(3):370-6
  Ziesché E, Scheiermann P, Bachmann M, Sadik CD, Hofstetter C, Zwissler B, Pfeilschifter J, Mühl H
  
• Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Clin Exp Immunol. 2009 Sep;157(3):370-6
  Ziesché E, Scheiermann P, Bachmann M, Sadik CD, Hofstetter C, Zwissler B, Pfeilschifter J, Mühl H
  
• Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma. Biochem Biophys Res Commun. 2009 Mar 6;380(2):387-91
  Gutwein P, Schramme A, Voss B, Abdel-Bakky MS, Doberstein K, Ludwig A, Altevogt P, Hansmann ML, Moch H, Kristiansen G, Pfeilschifter J
  
• Factor VIII-eGFP fusion proteins with preserved functional activity for the analysis of the early secretory pathway of factor VIII. Thromb Haemost. 2009 Nov;102(5):925-35
  Heinz S, Schüttrumpf J, Simpson JC, Pepperkok R, Nicolaes GA, Abriss D, Milanov P, Roth S, Seifried E, Tonn T
  
• Factor VIII-eGFP fusion proteins with preserved functional activity for the analysis of the early secretory pathway of factor VIII. Thromb Haemost. 2009 Nov;102(5):925-35
  Heinz S, Schüttrumpf J, Simpson JC, Pepperkok R, Nicolaes GA, Abriss D, Milanov P, Roth S, Seifried E, Tonn T
  
• Induction of programmed cell death in ErbB2/HER2-expressing cancer cells by targeted delivery of apoptosis-inducing factor. Mol Cancer Ther. 2009 Jun;8(6):1526-35
  Mahmud H, Dälken B, Wels WS
  
• Mcl-1-mediated impairment of the intrinsic apoptosis pathway in circulating neutrophils from critically ill patients can be overcome by Fas stimulation. J Immunol. 2009 Nov 15;183(10):6198-206
  Paunel-Görgülü A, Zörnig M, Lögters T, Altrichter J, Rabenhorst U, Cinatl J, Windolf J, Scholz M
  
• Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells. J Immunol. 2009 Apr 1;182(7):4183-91
  Richter C, Juan MH, Will J, Brandes RP, Kalinke U, Akira S, Pfeilschifter JM, Hultqvist M, Holmdahl R, Radeke HH
  
• Optical imaging of cellular immunotherapy against prostate cancer. Mol Imaging. 2009 Jan-Feb;8(1):15-26
  Tavri S, Jha P, Meier R, Henning TD, Müller T, Hostetter D, Knopp C, Johansson M, Reinhart V, Boddington S, Sista A, Wels WS, Daldrup-Link HE
  
• Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth. Hepatology. 2009 Oct;50(4):1121-9
  Rabenhorst U, Beinoraviciute-Kellner R, Brezniceanu ML, Joos S, Devens F, Lichter P, Rieker RJ, Trojan J, Chung HJ, Levens DL, Zörnig M
  
• Protein scaffold and expression level determine antiviral activity of membraneanchored antiviral peptides. Hum Gene Ther. 2009 Apr;20(4):325-36
  Hermann FG, Martinius H, Egelhofer M, Giroglou T, Tonn T, Roth SD, Zahn R, Schult-Dietrich P, Alexandrov A, Dietrich U, Baum C, von Laer D
  
• Pseudotyping lentiviral vectors with the wild-type measles virus glycoproteins improves titer and selectivity. Gene Ther. 2009 May;16(5):700-5
  Funke S, Schneider IC, Glaser S, Muehlebach MD, Moritz T, Cattaneo R, Cichutek K, Buchholz CJ
  
• Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj. PLoS One. 2009 Sep 21;4(9):e7098
  Schüle S, Kloke BP, Kaiser JK, Heidmeier S, Panitz S, Wolfrum N, Cichutek K, Schweizer M
  
• Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet. J Biol Chem. 2009 Feb 27;284(9):5819-26
  Perkovic M, Schmidt S, Marino D, Russell RA, Stauch B, Hofmann H, Kopietz F, Kloke BP, Zielonka J, Ströver H, Hermle J, Lindemann D, Pathak VK, Schneider G, Löchelt M, Cichutek K, Münk C
  
• The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158. Chembiochem. 2009 Jan 5;10(1):119-27
  Rehm S, Han S, Hassani I, Sokočević A, Jonker HR, Engels JW, Schwalbe H
  
• TLR2 ligands augment cPLA2alpha activity and lead to enhanced leukotriene release in human monocytes. J Leukoc Biol. 2009 Aug;86(2):389-99
  Lindner SC, Koehl U, Maier TJ, Steinhilber D, Sorg BL
  
• Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients. Eur J Cancer. 2009 Feb;45(3):478-89
  Gutwein P, Schramme A, Sinke N, Abdel-Bakky MS, Voss B, Obermüller N, Doberstein K, Koziolek M, Fritzsche F, Johannsen M, Jung K, Schaider H, Altevogt P, Ludwig A, Pfeilschifter J, Kristiansen G
  
• 5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity. Br J Pharmacol. 2010 Oct;161(4):936-49
  Fischer AS, Metzner J, Steinbrink SD, Ulrich S, Angioni C, Geisslinger G, Steinhilber D, Maier TJ
  
• 5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis. Front Pharmacol. 2010 Dec 24;1:143
  Steinhilber D, Fischer AS, Metzner J, Steinbrink SD, Roos J, Ruthardt M, Maier TJ
  
• ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases. J Biomed Sci. 2010 Jan 13;17:3
  Gutwein P, Schramme A, Abdel-Bakky MS, Doberstein K, Hauser IA, Ludwig A, Altevogt P, Gauer S, Hillmann A, Weide T, Jespersen C, Eberhardt W, Pfeilschifter J
  
• ADAM10 is upregulated in melanoma metastasis compared with primary melanoma. J Invest Dermatol. 2010 Mar;130(3):763-73
  Lee SB, Schramme A, Doberstein K, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, Pfeilschifter J, Mihic-Probst D, Gutwein P
  
• ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma. Biochem Biophys Res Commun.2010 Oct 22;401(3):363-9
  Ungerer C, Doberstein K, Bürger C, Hardt K, Boehncke WH, Böhm B, Pfeilschifter J, Dummer R, Mihic-Probst D, Gutwein P
  
• An improved bicistronic CD20/tCD34 vector for efficient purification and in vivo depletion of gene-modified T cells for adoptive immunotherapy. Mol Ther. 2010 Jul;18(7):1330-8
  Vogler I, Newrzela S, Hartmann S, Schneider N, von Laer D, Koehl U, Grez M
  
• CD271 antigen defines a subset of multipotent stromal cells with immunosuppressive and lymphohematopoietic engraftment-promoting properties. Haematologica. 2010 Apr;95(4):651-9
  Kuçi S, Kuçi Z, Kreyenberg H, Deak E, Pütsch K, Huenecke S, Amara C, Koller S, Rettinger E, Grez M, Koehl U, Latifi-Pupovci H, Henschler R, Tonn T, von Laer D, Klingebiel T, Bader P
  
• Cutaneous T-cell lymphoma cells are sensitive to rapamycin. Exp Dermatol. 2010 Sep;19(9):800-5
  Kremer M, Sliva K, Klemke CD, Schnierle BS
  
• Decreased HIV diversity after allogeneic stem cell transplantation of an HIV-1 infected patient: a case report. Virol J. 2010 Mar 8;7:55
  Kamp C, Wolf T, Bravo IG, Kraus B, Krause B, Neumann B, Winskowsky G, Thielen A, Werner A, Schnierle BS
  
• Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1. PLoS Pathog. 2010 Oct 14;6(10):e1001144
  Bachmann M, Horn K, Rudloff I, Goren I, Holdener M, Christen U, Darsow N, Hunfeld KP, Koehl U, Kind P, Pfeilschifter J, Kraiczy P, Mühl H
  
• Functional HIV-2- and SIVsmmPBjderived lentiviral vectors generated by a novel polymerase chain reaction-based approach. J Gene Med. 2010 May;12(5):446-52
  Kloke BP, Schüle S, Muehlebach MD, Wolfrum N, Cichutek K, Schweizer M
  
• Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med. 2010Feb;16(2):198-204
  Stein S, Ott MG, Schultze-Strasser S, Jauch A, Burwinkel B, Kinner A, Schmidt M, Krämer A, Schwäble J, Glimm H, Koehl U, Preiss C, Ball C, Martin H, Göhring G, Schwarzwaelder K, Hofmann WK, Karakaya K, Tchatchou S, Yang R, Reinecke P, Kühlcke K, Schlegelberger B, Thrasher AJ, Hoelzer D, Seger R, von Kalle C, Grez M
  
• IL-2- driven regulation of NK cell receptors with regard to the distribution of CD16+ and CD16- subpopulations and in vivo influence after haploidentical NK cell infusion. J Immunother. 2010 Feb-Mar;33(2):200-10
  Huenecke S, Zimmermann SY, Kloess S, Esser R, Brinkmann A, Tramsen L, Koenig M, Erben S, Seidl C, Tonn T, Eggert A, Schramm A, Bader P, Klingebiel T, Lehrnbecher T, Passweg JR, Soerensen J, Schwabe D, Koehl U
  
• IL-2-activated haploidentical NK cells restore NKG2D-mediated NK-cell cytotoxicity in neuroblastoma patients by scavenging of plasma MICA. Eur J Immunol. 2010;40(11):3255-67
  Kloess S, Huenecke S, Piechulek D, Esser R, Koch J, Brehm C, Soerensen J, Gardlowski T, Brinkmann A, Bader P, Passweg J, Klingebiel T, Schwabe D, Koehl U
  
• Inhibition of HIV-1 entry: multiple keys to close the door. ChemMedChem. 2010 Nov 8;5(11):1825-35
  Hertje M, Zhou M, Dietrich U
  
• Interleukin-22 detected in patients with abdominal sepsis. Shock. 2010 Oct;34(4):337-40
  Bingold TM, Ziesché E, Scheller B, Sadik CD, Franck K, Just L, Sartorius S, Wahrmann M, Wissing H, Zwissler B, Pfeilschifter J, Mühl H
  
• Maltose-binding protein enhances secretion of recombinant human granzyme B accompanied by in vivo processing of a precursor MBP fusion protein. PLoS One. 2010 Dec 22;5(12):e14404
  Dälken B, Jabulowsky RA, Oberoi P, Benhar I, Wels WS
  
• Maltose-binding protein enhances secretion of recombinant human granzyme B accompanied by in vivo processing of a precursor MBP fusion protein. PLoS One. 2010 Dec 22;5(12):e14404
  Dälken B, Jabulowsky RA, Oberoi P, Benhar I, Wels WS
  
• Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation. Stem Cells. 2010 May;28(5):928-38
  Vafaizadeh V, Klemmt P, Brendel C, Weber K, Doebele C, Britt K, Grez M, Fehse B, Desriviéres S, Groner B
  
• Multivariate analyses of immune reconstitution in children after allo-SCT: risk-estimation based on age-matched leukocyte sub-populations. Bone Marrow Transplant. 2010 Apr;45(4):613-21
  Koenig M, Huenecke S, Salzmann-Manrique E, Esser R, Quaritsch R, Steinhilber D, Radeke HH, Martin H, Bader P, Klingebiel T, Schwabe D, Schneider G, Lehrnbecher T, Orth A, Koehl U
  
• Nitric oxide mediates distinct effects of various LPS chemotypes on phagocytosis and leukotriene synthesis in human neutrophils. Int J Biochem Cell Biol. 2010 Jun;42(6):921-31
  Zagryazhskaya AN, Lindner SC, Grishina ZV, Galkina SI, Steinhilber D, Sud’ina GF
  
• Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors. Nat Methods. 2010 Nov;7(11):929-35
  Anliker B, Abel T, Kneissl S, Hlavaty J, Caputi A, Brynza J, Schneider IC, Münch RC, Petznek H, Kontermann RE, Koehl U, Johnston IC, Keinänen K, Müller UC, Hohenadl C, Monyer H, Cichutek K, Buchholz CJ
  
• Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations. Cell Mol Life Sci. 2010 Mar;67(5):797-806
  Steinbrink SD, Pergola C, Bühring U, George S, Metzner J, Fischer AS, Häfner AK, Wisniewska JM, Geisslinger G, Werz O, Steinhilber D, Maier TJ
  
• Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection. PLoS One. 2010 Aug 23;5(8):e12357
  Kimpel J, Braun SE, Qiu G, Wong FE, Conolle M, Schmitz JE, Brendel C, Humeau LM, Dropulic B, Rossi JJ, Berger A, von Laer D, Johnson RP
  
• TK.007: A novel, codon-optimized HSVtk(A168H) mutant for suicide gene therapy. Hum Gene Ther. 2010 Aug;21(8):929-41
  Preuss E, Treschow A, Newrzela S, Brücher D, Weber K, Felldin U, Alici E, Gahrton G, von Laer D, Dilber MS, Fehse B
  
• [Gene therapy for septic granulomatosis: risks and opportunities. The road to successful treatment of congenital immunodeficiency]. Pharm Unserer Zeit. 2011 May;40(3):264-71. German
  Schwäble J, Schultze-Strasser S, Stein S, Grez M
  
• A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm. Br J Pharmacol. 2011 Aug;163(8):1721-32
  : Revermann M, Mieth A, Popescu L, Paulke A, Wurglics M, Pellowska M, Fischer AS, Steri R, Maier TJ, Schermuly RT, Geisslinger G, Schubert-Zsilavecz M, Brandes RP, Steinhilber D
  
• Advanced flowcytometric analysis of regulatory T cells: CD127 downregulation early post stem cell transplantation and altered Treg/CD3(+)CD4(+)-ratio in severe GvHD or relapse. J Immunol Methods. 2011 Oct 28;373(1-2):36-44
  Bremm M, Huenecke S, Lehrnbecher T, Ponstingl E, Mueller R, Heinze A, Bug G, Quaiser A, Kapinsky M, Brehm C, Bader P, Schneider G, Klingebiel T, Koehl U
  
• Advanced flowcytometric analysis of regulatory T cells: CD127 downregulation early post stem cell transplantation and altered Treg/CD3(+)CD4(+)-ratio in severe GvHD or relapse. J Immunol Methods. 2011 Oct 28;373(1-2):36-44
  Bremm M, Huenecke S, Lehrnbecher T, Ponstingl E, Mueller R, Heinze A, Bug G, Quaiser A, Kapinsky M, Brehm C, Bader P, Schneider G, Klingebiel T, Koehl U
  
• Advanced flowcytometric analysis of regulatory T cells: CD127 downregulation early post stem cell transplantation and altered Treg/CD3(+)CD4(+)-ratio in severe GvHD or relapse. J Immunol Methods. 2011;373(1-2):36-44
  Bremm M, Huenecke S, Lehrnbecher T, Ponstingl E, Mueller R, Heinze A, Bug G, Quaiser A, Kapinsky M, Brehm C, Bader P, Schneider G, Klingebiel T, Koehl U
  
• Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells. Mol Ther. 2011 Jan;19(1):122-32
  Santilli G, Almarza E, Brendel C, Choi U, Beilin C, Blundell MP, Haria S, Parsley KL, Kinnon C, Malech HL, Bueren JA, Grez M, Thrasher AJ
  
• Biophysical characterization of α-amylase inhibitor Parvulustat (Z-2685) and comparison with Tendamistat (HOE-467). Biochim Biophys Acta. 2011 Oct;1814(10):1383-93
  Sokočević A, Han S, Engels JW
  
• Cancer suicide gene therapy with TK.007: superior killing efficiency and bystander effect. J Mol Med (Berl). 2011 Nov;89(11):1113-24
  Preuss E, Muik A, Weber K, Otte J, von Laer D, Fehse B
  
• Cancer suicide gene therapy with TK.007: superior killing efficiency and bystander effect. J Mol Med (Berl). 2011 Nov;89(11):1113-24
  Preuss E, Muik A, Weber K, Otte J, von Laer D, Fehse B
  
• Characterization of the human endogenous retrovirus K Gag protein: identification of protease cleavage sites. Retrovirology. 2011 Mar 23;8:21
  Kraus B, Boller K, Reuter A, Schnierle BS
  
• Comparative analysis of transduced primary human dendritic cells generated by the use of three different lentiviral vector systems. Mol Biotechnol. 2011 Mar;47(3):262-9
  Grabski E, Waibler Z, Schüle S, Kloke BP, Sender LY, Panitz S, Cichutek K, Schweizer M, Kalinke U
  
• Depicting adoptive immunotherapy for prostate cancer in an animal model with magnetic resonance imaging. Magn Reson Med. 2011 Mar;65(3):756-63
  Meier R, Golovko D, Tavri S, Henning TD, Knopp C, Piontek G, Rudelius M, Heinrich P, Wels WS, Daldrup-Link H
  
• Human natural killer cells exhibit direct activity against Aspergillus fumigatus hyphae, but not against resting conidia. J Infect Dis. 2011 Feb 1;203(3):430-5
  Schmidt S, Tramsen L, Hanisch M, Latgé JP, Huenecke S, Koehl U, Lehrnbecher T
  
• IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study. PLoS One. 2011;6(11):e27351
  Brehm C, Huenecke S, Quaiser A, Esser R, Bremm M, Kloess S, Soerensen J, Kreyenberg H, Seidl C, Becker PS, Mühl H, Klingebiel T, Bader P, Passweg JR, Schwabe D, Koehl U
  
• IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study. PLoS One. 2011;6(11):e27351
  Brehm C, Huenecke S, Quaiser A, Esser R, Bremm M, Kloess S, Soerensen J, Kreyenberg H, Seidl C, Becker PS, Mühl H, Klingebiel T, Bader P, Passweg JR, Schwabe D, Koehl U
  
• IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study. PLoS One. 2011;6(11):e27351
  Brehm C, Huenecke S, Quaiser A, Esser R, Bremm M, Kloess S, Soerensen J, Kreyenberg H, Seidl C, Becker PS, Mühl H, Klingebiel T, Bader P, Passweg JR, Schwabe D, Koehl U
  
• IL-2-activated haploidentical NK cells restore NKG2D-mediated NK-cell cytotoxicity in neuroblastoma patients by scavenging of plasma MICA. Eur J Immunol. 2010 Nov;40(11):3255-67
  Kloess S, Huenecke S, Piechulek D, Esser R, Koch J, Brehm C, Soerensen J, Gardlowski T, Brinkmann A, Bader P, Passweg J, Klingebiel T, Schwabe D, Koehl U
  
• Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation. Carcinogenesis. 2011; 32(10):1427-33
  Schmid T, Bajer MM, Blees JS, Eifler LK, Milke L, Rübsamen D, Schulz K, Weigert A, Baker AR, Colburn NH, Brüne B
  
• Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study. BMC Med. 2012 Sep 11;10:102
  Kronenberger B, Rudloff I, Bachmann M, Brunner F, Kapper L, Filmann N, Waidmann O, Herrmann E, Pfeilschifter J, Zeuzem S, Piiper A, Mühl H
  
• L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells. Carcinogenesis. 2011 Mar;32(3):262-70
  Doberstein K, Wieland A, Lee SB, Blaheta RA, Wedel S, Moch H, Schraml P, Pfeilschifter J, Kristiansen G, Gutwein P
  
• Mechanistic basis for RNA aptamer-based induction of TetR. Chembiochem. 2011 Nov 25;12(17):2608-14
  Steber M, Arora A, Hofmann J, Brutschy B, Suess B
  
• MicroRNAs as new players in the pain game. Pain. 2011 Jul;152(7):1455-8
  Niederberger E, Kynast K, Lötsch J, Geisslinger G
  
• Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain. PLoS One. 2011 Apr 29;6(4):e19270
  Kühlein HN, Tegeder I, Möser C, Lim HY, Häussler A, Spieth K, Jennes I, Marschalek R, Beckhaus T, Karas M, Fauth M, Ehnert C, Geisslinger G, Niederberger E
  
• PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells. PLoS One. 2011;6(8):e22312
  Lee SB, Doberstein K, Baumgarten P, Wieland A, Ungerer C, Bürger C, Hardt K, Boehncke WH, Pfeilschifter J, Mihic-Probst D, Mittelbronn M, Gutwein P
  
• Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury. Am J Respir Cell Mol Biol. 2011 Mar;44(3):369-76
  Hoegl S, Bachmann M, Scheiermann P, Goren I, Hofstetter C, Pfeilschifter J, Zwissler B, Mühl H
  
• Pseudotyping vesicular stomatitis virus with lymphocytic choriomeningitis virus glycoproteins enhances infectivity for glioma cells and minimizes neurotropism. J Virol. 2011 Jun;85(11):5679-84
  Muik A, Kneiske I, Werbizki M, Wilflingseder D, Giroglou T, Ebert O, Kraft A, Dietrich U, Zimmer G, Momma S, von Laer D
  
• Reciprocal cross talk between fatty acid and antibiotic biosynthesis in a nematode symbiont. Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma. PLoS One. 2011;6(10):e26971
  Bihrer V, Waidmann O, Friedrich-Rust M, Forestier N, Susser S, Haupenthal J, Welker M, Shi Y, Peveling-Oberhag J, Polta A, von Wagner M, Radeke HH, Sarrazin C, Trojan J, Zeuzem S, Kronenberger B, Piiper A
  
• Resting lymphocyte transduction with measles virus glycoprotein pseudotyped lentiviral vectors relies on CD46 and SLAM. Virology. 2011 May 10;413(2):149-52
  Zhou Q, Schneider IC, Gallet M, Kneissl S, Buchholz CJ
  
• Retroviral insertional mutagenesis can contribute to immortalization of mature T lymphocytes. Mol Med. 2011;17(11-12):1223-32
  Newrzela S, Cornils K, Heinrich T, Schläger J, Yi JH, Lysenko O, Kimpel J, Fehse B, von Laer D
  
• S1P regulation of macrophage functions in the context of cancer. Anticancer Agents Med Chem. 2011 Nov;11(9):818-29
  Weigert A, Weichand B, Brüne B
  
• Secreted antiviral entry inhibitory (SAVE) peptides for gene therapy of HIV infection. Mol Ther. 2011 Jul;19(7):1236-44
  Egerer L, Volk A, Kahle J, Kimpel J, Brauer F, Hermann FG, von Laer D
  
• Secreted antiviral entry inhibitory (SAVE) peptides for gene therapy of HIV infection. Mol Ther. 2011 Jul;19(7):1236-44
  Egerer L, Volk A, Kahle J, Kimpel J, Brauer F, Hermann FG, von Laer D
  
• Selection of tetracycline inducible self-cleaving ribozymes as synthetic devices for gene regulation in yeast. Mol Biosyst. 2011 Aug;7(8):2419-27
  Wittmann A, Suess B
  
• Serum miR-122 as a biomarker of necroinflammation in patients with chronic hepatitis C virus infection. Am J Gastroenterol. 2011 Sep;106(9):1663-9
  Bihrer V, Friedrich-Rust M, Kronenberger B, Forestier N, Haupenthal J, Shi Y, Peveling-Oberhag J, Radeke HH, Sarrazin C, Herrmann E, Zeuzem S, Waidmann O, Piiper A
  
• Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21. Sci Signal. 2011 Nov 15;4(199):ra75
  Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhão JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  
• The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia. J Immunol. 2011 Sep 1;187(5):2617-25
  Möser CV, Kynast K, Baatz K, Russe OQ, Ferreirós N, Costiuk H, Lu R, Schmidtko A, Tegeder I, Geisslinger G, Niederberger E
  
• The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia. J Immunol. 2011 Sep 1;187(5):2617-25
  Möser CV, Kynast K, Baatz K, Russe OQ, Ferreirós N, Costiuk H, Lu R, Schmidtko A, Tegeder I, Geisslinger G, Niederberger E
  
• The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia. J Immunol. 2011 Sep 1;187(5):2617-25
  Möser CV, Kynast K, Baatz K, Russe OQ, Ferreirós N, Costiuk H, Lu R, Schmidtko A, Tegeder I, Geisslinger G, Niederberger E
  
• The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia. J Immunol. 2011 Sep 1;187(5):2617-25
  Möser CV, Kynast K, Baatz K, Russe OQ, Ferreirós N, Costiuk H, Lu R, Schmidtko A, Tegeder I, Geisslinger G, Niederberger E
  
• The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. Mol Immunol. 2011 May;48(9-10):1139-48
  Schröder M, Richter C, Juan MH, Maltusch K, Giegold O, Quintini G, Pfeilschifter JM, Huwiler A, Radeke HH
  
• The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. Mol Immunol. 2011 May;48(9-10):1139-48
  Schröder M, Richter C, Juan MH, Maltusch K, Giegold O, Quintini G, Pfeilschifter JM, Huwiler A, Radeke HH
  
• The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. Mol Immunol. 2011 May;48(9-10):1139-48
  Schröder M, Richter C, Juan MH, Maltusch K, Giegold O, Quintini G, Pfeilschifter JM, Huwiler A, Radeke HH
  
• The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma. Carcinogenesis. 2011 Nov;32(11):1713-23
  Doberstein K, Pfeilschifter J, Gutwein P
  
• Tracking the activation of Stat5 through the expression of an inducible reporter gene in a transgenic mouse line. Endocrinology. 2011;152(5):1935-47
  Bednorz NL, Brill B, Klein A, Gäbel K, Groner B
  
• Transgene loss and changes in the promoter methylation status as determinants for expression duration in nonviral gene transfer for factor IX. Hum Gene Ther. 2011 Jan;22(1):101-6
  Schüttrumpf J, Milanov P, Abriss D, Roth S, Tonn T, Seifried E
  
• Transgene loss and changes in the promoter methylation status as determinants for expression duration in nonviral gene transfer for factor IX. Hum Gene Ther. 2011 Jan;22(1):101-6
  Schüttrumpf J, Milanov P, Abriss D, Roth S, Tonn T, Seifried E
  
• : Tréguer K, Heinrich EM, Ohtani K, Bonauer A, Dimmeler S. Role of the microRNA-17-92 cluster in the endothelial differentiation of stem cells. J Vasc Res. 2012;49(5):447-60
  Tréguer K, Heinrich EM, Ohtani K, Bonauer A, Dimmeler S
  
• A membrane penetrating peptide aptamer inhibits STAT3 function and suppresses the growth of STAT3 addicted tumor cells. JAKSTAT. 2012 Jan 1;1(1):44-54
  Borghouts C, Delis N, Brill B, Weiss A, Mack L, Lucks P, Groner B
  
• A membrane penetrating peptide aptamer inhibits STAT3 function and suppresses the growth of STAT3 addicted tumor cells. JAKSTAT. 2012 Jan 1;1(1):44-54
  Borghouts C, Delis N, Brill B, Weiss A, Mack L, Lucks P, Groner B
  
• Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity. Mol Ther. 2012 May;20(5):1022-32
  Suerth JD, Maetzig T, Brugman MH, Heinz N, Appelt JU, Kaufmann KB, Schmidt M, Grez M, Modlich U, Baum C, Schambach A
  
• Biglycan: a multivalent proteoglycan providing structure and signals. J Histochem Cytochem. 2012 Dec;60(12):963-75
  Nastase MV, Young MF, Schaefer L
  
• Biochemical analysis of the complex between the tetrameric export adapter protein Rec of HERV-K/HML-2 and the responsive RNA element RcRE pck30. J Virol. 2012 Sep;86(17):9079-87
  Langner JS, Fuchs NV, Hoffmann J, Wittmann A, Brutschy B, Löwer R, Suess B
  
• Biochemical analysis of the complex between the tetrameric export adapter protein Rec of HERV-K/HML-2 and the responsive RNA element RcRE pck30. J Virol. 2012 Sep;86(17):9079-87
  Langner JS, Fuchs NV, Hoffmann J, Wittmann A, Brutschy B, Löwer R, Suess B
  
• Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A. PLoS One. 2012;7(9):e44505
  Roth SD, Schüttrumpf J, Milanov P, Abriss D, Ungerer C, Quade-Lyssy P, Simpson JC, Pepperkok R, Seifried E, Tonn T
  
• Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A. PLoS One. 2012;7(9):e44505
  Roth SD, Schüttrumpf J, Milanov P, Abriss D, Ungerer C, Quade-Lyssy P, Simpson JC, Pepperkok R, Seifried E, Tonn T
  
• Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A. PLoS One. 2012;7(9):e44505
  Roth SD, Schüttrumpf J, Milanov P, Abriss D, Ungerer C, Quade-Lyssy P, Simpson JC, Pepperkok R, Seifried E, Tonn T
  
• Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A. PLoS One.2012;7(9):e44505
  Roth SD, Schüttrumpf J, Milanov P, Abriss D, Ungerer C, Quade-Lyssy P, Simpson JC, Pepperkok R, Seifried E, Tonn T
  
• Comparison of three humanized mouse models for adoptive T cell transfer. J Gene Med. 2012 Aug;14(8):540-8
  Volk A, Hartmann S, Muik A, Geiss Y, Königs C, Dietrich U, von Laer D, Kimpel J
  
• Comparison of three humanized mouse models for adoptive T cell transfer. J Gene Med. 2012 Aug;14(8):540-8
  Volk A, Hartmann S, Muik A, Geiss Y, Königs C, Dietrich U, von Laer D, Kimpel J
  
• Comparison of three humanized mouse models for adoptive T cell transfer. J Gene Med. 2012 Aug;14(8):540-8
  Volk A, Hartmann S, Muik A, Geiss Y, Königs C, Dietrich U, von Laer D, Kimpel J
  
• Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex. Cell Metab. 2012 Oct 3;16(4):538-49
  Heide H, Bleier L, Steger M, Ackermann J, Dröse S, Schwamb B, Zörnig M, Reichert AS, Koch I, Wittig I, Brandt U
  
• Contrast enhancement of the brain by folate-conjugated gadolinium-diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging. Mol Imaging. 2012 Jul-Aug;11(4):272-9
  Korkusuz H, Ulbrich K, Bihrer V, Welzel K, Chernikov V, Knobloch T, Petersen S, Huebner F, Ackermann H, Gelperina S, Korkusuz Y, Kromen W, Hammerstingl R, Haupenthal J, Fiehler J, Zeuzem S, Kreuter J, Vogl TJ, Piiper A
  
• Cytotoxic Capacity of IL-15-Stimulated Cytokine-Induced Killer Cells Against Human Acute Myeloid Leukemia and Rhabdomyosarcoma in Humanized Preclinical Mouse Models. Front Oncol. 2012 Apr 9;2:32
  Rettinger E, Meyer V, Kreyenberg H, Volk A, Kuçi S, Willasch A, Koscielniak E, Fulda S, Wels WS, Boenig H, Klingebiel T, Bader P
  
• Different signal intensity at Gd-EOB- DTPA compared with Gd-DTPA-enhanced MRI in hepatocellular carcinoma transgenic mouse model in delayed phase hepatobiliary imaging. J Magn Reson Imaging. 2012 Jun;35(6):1397-402
  Korkusuz H, Knau LL, Kromen W, Bihrer V, Keese D, Piiper A, Vogl TJ
  
• Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice. Blood. 2012 Jan 12;119(2):602-11
  Milanov P, Ivanciu L, Abriss D, Quade-Lyssy P, Miesbach W, Alesci S, Tonn T, Grez M, Seifried E, Schüttrumpf J
  
• Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice. Blood. 2012 Jan 12;119(2):602-11
  Milanov P, Ivanciu L, Abriss D, Quade-Lyssy P, Miesbach W, Alesci S, Tonn T, Grez M, Seifried E, Schüttrumpf J
  
• Engineered riboswitches: Expanding researchers’ toolbox with synthetic RNA regulators. FEBS Lett. 2012 Jul 16;586(15):2076-83
  Wittmann A, Suess B
  
• Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1. PLoS One. 2012;7(10):e46567
  Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B
  
• Expression of human endogenous retrovirus-K coincides with that of micro- RNA-663 and -638 in germ-cell tumor cells. Anticancer Res. 2012 Nov;32(11):4797-804
  Kraus B, Mönk B, Sliva K, Schnierle BS
  
• Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor. Cancer Immunol Immunother. 2012 Sep;61(9):1451-61
  Sahm C, Schönfeld K, Wels WS
  
• Gadoxetate acid-enhanced MRI of hepatocellular carcinoma in a c-myc/TGFα transgenic mouse model including signal intensity and fat content: initial experience. Cancer Imaging. 2012 Mar 7;12:72-8
  Korkusuz H, Knau L, Kromen W, Huebner F, Hammerstingl R, Lindemayr S, Bihrer V, Piiper A, Vogl TJ
  
• HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo. Blood. 2012 Oct 11;120(15):3001-6
  Weigert A, Weichand B, Sekar D, Sha W, Hahn C, Mora J, Ley S, Essler S, Dehne N, Brüne B
  
• IL-15 augments antitumoral activity of an ErbB2/HER2 cancer vaccine targeted to professional antigen-presenting cells. Cancer Immunol Immunother. 2012 Sep;61(9):1473-84
  Burkhardt UE, Sloots A, Jakobi V, Wei WZ, Cavallo F, Kloke BP, Wels WS
  
• IL-36γ/IL-1F9, an innate T-bet target in myeloid cells. J Biol Chem. 2012 Dec 7;287(50):41684-96
  Bachmann M, Scheiermann P, Härdle L, Pfeilschifter J, Mühl H
  
• IL-36γ/IL-1F9, an innate T-bet target in myeloid cells. J Biol Chem. 2012 Dec 7;287(50):41684-96
  Bachmann M, Scheiermann P, Härdle L, Pfeilschifter J, Mühl H
  
• Increasing the range of drug targets: interacting peptides provide leads for the development of oncoprotein inhibitors. Bioengineered. 2012 Nov-Dec;3(6):320-5
  Groner B, Weber A, Mack L
  
• Inhibition of Stat3 by peptide aptamer rS3-PA enhances growth suppressive effects of irinotecan on colorectal cancer cells. Horm Mol Biol Clin Investig. 2012 Jun;10(2):273-9
  Weber A, Borghouts C, Delis N, Mack L, Brill B, Bernard AC, Coqueret O, Groner B
  
• LC-MS/MS determination of FTY720 and FTY720- phosphate in murine intracellular compartments and human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 1;887-888:122-7
  Ferreirós N, Labocha S, Schröder M, Radeke HH, Geisslinger G
  
• Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model. Mol Ther. 2012 May;20(5):908-17
  Vets S, Kimpel J, Volk A, De Rijck J, Schrijvers R, Verbinnen B, Maes W, Von Laer D, Debyser Z, Gijsbers R
  
• Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model. Mol Ther. 2012 May;20(5):908-17
  Vets S, Kimpel J, Volk A, De Rijck J, Schrijvers R, Verbinnen B, Maes W, Von Laer D, Debyser Z, Gijsbers R
  
• Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development. RNA Biol. 2012 Aug;9(8):1076-87
  Eißmann M, Gutschner T, Hämmerle M, Günther S, Caudron-Herger M, Groß M, Schirmacher P, Rippe K, Braun T, Zörnig M, Diederichs S
  
• Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies. PLoS One. 2012;7(10):e46667
  Kneissl S, Abel T, Rasbach A, Brynza J, Schneider-Schaulies J, Buchholz CJ
  
• Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies. PLoS One. 2012;7(10):e46667
  Kneissl S, Abel T, Rasbach A, Brynza J, Schneider-Schaulies J, Buchholz CJ
  
• Mechanisms of rapid induction of interleukin-22 in activated T cells and its modulation by cyclosporin a. J Biol Chem. 2012 Feb 10;287(7):4531-43
  Rudloff I, Bachmann M, Pfeilschifter J, Mühl H
  
• MicroRNAs and stem cells: control of pluripotency, reprogramming, and lineage commitment. Circ Res. 2012 Mar 30;110(7):1014-22
  Heinrich EM, Dimmeler S
  
• Molecular characterization of EP6--a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor. Biochem Pharmacol. 2012 Jan 15;83(2):228-40
  Wisniewska JM, Rödl CB, Kahnt AS, Buscató El, Ulrich S, Tanrikulu Y, Achenbach J, Rörsch F, Grösch S, Schneider G, Cinatl J Jr, Proschak E, Steinhilber D, Hofmann B
  
• Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor. Br J Pharmacol. 2012 Apr;165(7):2304-13
  Hofmann B, Rödl CB, Kahnt AS, Maier TJ, Michel AA, Hoffmann M, Rau O, Awwad K, Pellowska M, Wurglics M, Wacker M, Zivković A, Fleming I, Schubert-Zsilavecz M, Stark H, Schneider G, Steinhilber D
  
• NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury. J Neurosci. 2012 Jul 25;32(30):10136-45
  Kallenborn-Gerhardt W, Schröder K, Del Turco D, Lu R, Kynast K, Kosowski J, Niederberger E, Shah AM, Brandes RP, Geisslinger G, Schmidtko A
  
• Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter. Gene Ther. 2012 Oct;19(10):1018-29
  Brendel C, Müller-Kuller U, Schultze-Strasser S, Stein S, Chen-Wichmann L, Krattenmacher A, Kunkel H, Dillmann A, Antoniou MN, Grez M
  
• Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter. Gene Ther. 2012 Oct;19(10):1018-29
  Brendel C, Müller-Kuller U, Schultze-Strasser S, Stein S, Chen-Wichmann L, Krattenmacher A, Kunkel H, Dillmann A, Antoniou MN, Grez M
  
• Pretreatment serum microRNA-122 is not predictive for treatment response in chronic hepatitis C virus infection. Dig Liver Dis. 2012 May;44(5):438-41
  Waidmann O, Bihrer V, Kronenberger B, Zeuzem S, Piiper A, Forestier N
  
• Prime boost vaccination approaches with different conjugates of a new HIV-1 gp41 epitope encompassing the membrane proximal external region induce neutralizing antibodies in mice. Vaccine. 2012 Mar 2;30(11):1911-6
  Zhou M, Kostoula I, Brill B, Panou E, Sakarellos-Daitsiotis M, Dietrich U
  
• Reduced efficacy of the Plk1 inhibitor BI 2536 on the progression of hepatocellular carcinoma due to low intratumoral drug levels. Neoplasia. 2012 May;14(5):410-9
  Haupenthal J, Bihrer V, Korkusuz H, Kollmar O, Schmithals C, Kriener S, Engels K, Pleli T, Benz A, Canamero M, Longerich T, Kronenberger B, Richter S, Waidmann O, Vogl TJ, Zeuzem S, Piiper A
  
• Reduced efficacy of the Plk1 inhibitor BI 2536 on the progression of hepatocellular carcinoma due to low intratumoral drug levels. Neoplasia. 2012 May;14(5):410-9
  Haupenthal J, Bihrer V, Korkusuz H, Kollmar O, Schmithals C, Kriener S, Engels K, Pleli T, Benz A, Canamero M, Longerich T, Kronenberger B, Richter S, Waidmann O, Vogl TJ, Zeuzem S, Piiper A
  
• RNA-based networks: using RNA aptamers and ribozymes as synthetic genetic devices. Methods Mol Biol. 2012;813:157-68
  Weigand JE, Wittmann A, Suess B
  
• Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatinopening element through elimination of aberrant splicing. J Virol. 2012 Sep;86(17):9088-95
  Knight S, Zhang F, Mueller-Kuller U, Bokhoven M, Gupta A, Broughton T, Sha S, Antoniou MN, Brendel C, Grez M, Thrasher AJ, Collins M, Takeuchi Y
  
• Semireplication-competent vesicular stomatitis virus as a novel platform for oncolytic virotherapy. J Mol Med (Berl). 2012 Aug;90(8):959-70
  Muik A, Dold C, Geiß Y, Volk A, Werbizki M, Dietrich U, von Laer D
  
• Semireplication-competent vesicular stomatitis virus as a novel platform for oncolytic virotherapy. J Mol Med (Berl). 2012 Aug;90(8):959-70
  Muik A, Dold C, Geiß Y, Volk A, Werbizki M, Dietrich U, von Laer D
  
• Sequential anti-cytomegalovirus response monitoring may allow prediction of cytomegalovirus reactivation after allogeneic stem cell transplantation. PLoS One. 2012;7(12):e50248
  Borchers S, Bremm M, Lehrnbecher T, Dammann E, Pabst B, Wölk B, Esser R, Yildiz M, Eder M, Stadler M, Bader P, Martin H, Jarisch A, Schneider G, Klingebiel T, Ganser A, Weissinger EM, Koehl U
  
• Serum microRNA-122 levels in different groups of patients with chronic hepatitis B virus infection. J Viral Hepat. 2012 Feb;19(2):e58-65
  Waidmann O, Bihrer V, Pleli T, Farnik H, Berger A, Zeuzem S, Kronenberger B, Piiper A
  
• Serum microRNA-122 predicts survival in patients with liver cirrhosis. PLoS One. 2012;7(9):e45652
  Waidmann O, Köberle V, Brunner F, Zeuzem S, Piiper A, Kronenberger B
  
• Stat3 inhibition in neural lineage cells. Horm Mol Biol Clin Investig. 2012 Jun;10(2):255-63
  Chiba T, Mack L, Delis N, Brill B, Groner B
  
• Stat3 is activated in skin lesions by the local application of imiquimod, a ligand of TLR7, and inhibited by the recombinant peptide aptamer rS3-PA. Horm Mol Biol Clin Investig. 2012 Jun;10(2):265-72
  Mack L, Brill B, Delis N, Borghouts C, Weber A, Groner B
  
• Surface charge-modification prevents sequestration and enhances tumor-cell specificity of a recombinant granzyme B-TGFα fusion protein. Bioconjug Chem. 2012 Aug 15;23(8):1567-76
  Jabulowsky RA, Oberoi P, Bähr-Mahmud H, Dälken B, Wels WS
  
• Surface charge-modification prevents sequestration and enhances tumor-cell specificity of a recombinant granzyme B-TGFα fusion protein. Bioconjug Chem. 2012 Aug 15;23(8):1567-76
  Jabulowsky RA, Oberoi P, Bähr-Mahmud H, Dälken B, Wels WS
  
• Surface charge-modification prevents sequestration and enhances tumor-cell specificity of a recombinant granzyme B-TGFα fusion protein. Bioconjug Chem. 2012 Aug 15;23(8):1567-76
  Jabulowsky RA, Oberoi P, Bähr-Mahmud H, Dälken B, Wels WS
  
• Survivin inhibition by an interacting recombinant peptide, derived from the human ferritin heavy chain, impedes tumor cell growth. J Cancer Res Clin Oncol. 2012 Jul;138(7):1205-20
  Weiss A, Brill B, Borghouts C, Delis N, Mack L, Groner B
  
• Survivin inhibition by an interacting recombinant peptide, derived from the human ferritin heavy chain, impedes tumor cell growth. J Cancer Res Clin Oncol. 2012 Jul;138(7):1205-20
  Weiss A, Brill B, Borghouts C, Delis N, Mack L, Groner B
  
• T-cell receptor diversity prevents T-cell lymphoma development. Leukemia. 2012 Dec;26(12):2499-507
  Newrzela S, Al-Ghaili N, Heinrich T, Petkova M, Hartmann S, Rengstl B, Kumar A, Jäck HM, Gerdes S, Roeder I, Hansmann ML, von Laer D
  
• T-cell receptor diversity prevents T-cell lymphoma development. Newrzela Leukemia. 2012 Dec;26(12):2499-507
  Al-Ghaili N, Heinrich T, Petkova M, Hartmann S, Rengstl B, Kumar A, Jäck HM, Gerdes S, Roeder I, Hansmann ML, von Laer D
  
• T-cell receptor gene transfer exclusively to human CD8(+) cells enhances tumor cell killing. Blood. 2012 Nov 22;120(22):4334-42
  Zhou Q, Schneider IC, Edes I, Honegger A, Bach P, Schönfeld K, Schambach A, Wels WS, Kneissl S, Uckert W, Buchholz CJ
  
• The cellular antiviral restriction factor tetherin does not inhibit poxviral replication. J Virol. 2012 Feb;86(3):1893-6
  Sliva K, Resch T, Kraus B, Goffinet C, Keppler OT, Schnierle BS
  
• The dipeptidyl peptidase-4 inhibitor linagliptin attenuates inflammation and accelerates epithelialization in wounds of diabetic ob/ob mice. J Pharmacol Exp Ther. 2012 Jul;342(1):71-80
  Schürmann C, Linke A, Engelmann-Pilger K, Steinmetz C, Mark M, Pfeilschifter J, Klein T, Frank S
  
• The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors. Behav Brain Res. 2012 Sep 1;234(1):121-8
  Coste O, Möser CV, Sisignano M, Kynast KL, Minden A, Geisslinger G, Niederberger E
  
• The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors. Behav Brain Res. 2012 Sep 1;234(1):121-8
  Coste O, Möser CV, Sisignano M, Kynast KL, Minden A, Geisslinger G, Niederberger E
  
• A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes. PLoS One. 2013 May 22;8(5):e64873
  Eißmann M, Schwamb B, Melzer IM, Moser J, Siele D, Koehl U, Rieker RJ, Wachter DL, Agaimy A, Herpel E, Baumgarten P, Mittelbronn M, Rakel S, Kögel D, Böhm S, Gutschner T, Diederichs S, Zörnig M
  
• A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes. PLoS One. 2013 May 22;8(5):e64873
  Eißmann M, Schwamb B, Melzer IM, Moser J, Siele D, Koehl U, Rieker RJ, Wachter DL, Agaimy A, Herpel E, Baumgarten P, Mittelbronn M, Rakel S, Kögel D, Böhm S, Gutschner T, Diederichs S, Zörnig M
  
• A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes. PLoS One. 2013 May 22;8(5):e64873
  Eißmann M, Schwamb B, Melzer IM, Moser J, Siele D, Koehl U, Rieker RJ, Wachter DL, Agaimy A, Herpel E, Baumgarten P, Mittelbronn M, Rakel S, Kögel D, Böhm S, Gutschner T, Diederichs S, Zörnig M
  
• A rationally engineered anti- HIV peptide fusion inhibitor with greatly reduced immunogenicity. Antimicrob Agents Chemother. 2013 Feb;57(2):679-88
  Brauer F, Schmidt K, Zahn RC, Richter C, Radeke HH, Schmitz JE, von Laer D, Egerer L
  
• A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny. Stem Cells. 2013 Mar;31(3):488-99
  Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T
  
• Activation of the AMP- activated protein kinase reduces inflammatory nociception. J Pain. 2013 Nov;14(11):1330-40
  Russe OQ, Möser CV, Kynast KL, King TS, Stephan H, Geisslinger G, Niederberger E
  
• Activation of the AMP- activated protein kinase reduces inflammatory nociception. J Pain. 2013 Nov;14(11):1330-40
  Russe OQ, Möser CV, Kynast KL, King TS, Stephan H, Geisslinger G, Niederberger E
  
• Activation of the AMP- activated protein kinase reduces inflammatory nociception. J Pain. 2013 Nov;14(11):1330-40
  Russe OQ, Möser CV, Kynast KL, King TS, Stephan H, Geisslinger G, Niederberger E
  
• Activation of the AMP- activated protein kinase reduces inflammatory nociception. J Pain. 2013 Nov;14(11):1330-40
  Russe OQ, Möser CV, Kynast KL, King TS, Stephan H, Geisslinger G, Niederberger E
  
• Activation of the AMP-activated protein kinase reduces inflammatory nociception. J Pain. 2013 Nov;14(11):1330-40
  Russe OQ, Möser CV, Kynast KL, King TS, Stephan H, Geisslinger G, Niederberger E
  
• Age-matched dendritic cell subpopulations reference values in childhood. Scand J Immunol. 2013 Mar;77(3):213-20
  Heinze A, Elze MC, Kloess S, Ciocarlie O, Königs C, Betz S, Bremm M, Esser R, Klingebiel T, Serban M, Hutton JL, Koehl U
  
• Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing. Mol Ther. 2013 Mar;21(3):648-61
  Kaufmann KB, Brendel C, Suerth JD, Mueller-Kuller U, Chen-Wichmann L, Schwäble J, Pahujani S, Kunkel H, Schambach A, Baum C, Grez M
  
• Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing. Mol Ther. 2013 Mar;21(3):648-61
  Kaufmann KB, Brendel C, Suerth JD, Mueller-Kuller U, Chen-Wichmann L, Schwäble J, Pahujani S, Kunkel H, Schambach A, Baum C, Grez M
  
• Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing. Mol Ther. 2013 Mar;21(3):648-61
  Kaufmann KB, Brendel C, Suerth JD, Mueller-Kuller U, Chen-Wichmann L, Schwäble J, Pahujani S, Kunkel H, Schambach A, Baum C, Grez M
  
• Altered gene expression in the prefrontal cortex of young rats induced by the ADHD drug atomoxetine. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:221-8
  Lempp T, Toennes SW, Wunder C, Russe OQ, Möser CV, Kynast KL, Freitag CM, Niederberger E
  
• Altered gene expression in the prefrontal cortex of young rats induced by the ADHD drug atomoxetine. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:221-8
  Lempp T, Toennes SW, Wunder C, Russe OQ, Möser CV, Kynast KL, Freitag CM, Niederberger E
  
• Altered gene expression in the prefrontal cortex of young rats induced by the ADHD drug atomoxetine. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:221-8
  Lempp T, Toennes SW, Wunder C, Russe OQ, Möser CV, Kynast KL, Freitag CM, Niederberger E
  
• Apoptotic cells enhance sphingosine-1- phosphate receptor 1 dependent macrophage migration. Eur J Immunol. 2013 Dec;43(12):3306-13
  Weichand B, Weis N, Weigert A, Grossmann N, Levkau B, Brüne B
  
• Application of interleukin-22 mediates protection in experimental acetaminophen-induced acute liver injury. Am J Pathol. 2013 Apr;182(4):1107-13
  Scheiermann P, Bachmann M, Goren I, Zwissler B, Pfeilschifter J, Mühl H
  
• Arming NK cells with enhanced antitumor activity: CARs and beyond. Oncoimmunology. 2013 Aug 1;2(8):e25220
  Oberoi P, Wels WS
  
• Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice. PLoS One. 2013;8(1):e54675
  Christen S, Coppieters K, Rose K, Holdener M, Bayer M, Pfeilschifter JM, Hintermann E, von Herrath MG, Aurrand- Lions M, Imhof BA, Christen U
  
• Bone morphogenetic protein-9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells. Cancer Sci. 2013 Mar;104(3):398-408
  Li Q, Gu X, Weng H, Ghafoory S, Liu Y, Feng T, Dzieran J, Li L, Ilkavets I, Kruithof-de Julio M, Munker S, Marx A, Piiper A, Augusto Alonso E, Gretz N, Gao C, Wölfl S, Dooley S, Breitkopf-Heinlein K
  
• CD19 and CD20 targeted vectors induce minimal activation of resting B lymphocytes. PLoS One. 2013 Nov 11;8(11):e79047
  Kneissl S, Zhou Q, Schwenkert M, Cosset FL, Verhoeyen E, Buchholz CJ
  
• Cell type specific gene delivery by lentiviral vectors: New options in immunotherapy. Oncoimmunology. 2013 Jan 1;2(1):e22566
  Zhou Q, Buchholz CJ
  
• Ceramide metabolism in mouse tissue. Int J Biochem Cell Biol. 2013 Aug;45(8):1886-94
  Schiffmann S, Birod K, Männich J, Eberle M, Wegner MS, Wanger R, Hartmann D, Ferreiros N, Geisslinger G, Grösch S
  
• Clinical grade purification and expansion of NK cell products for an optimized manufacturing protocol. Front Oncol. 2013 May 17;3:118
  Koehl U, Brehm C, Huenecke S, Zimmermann SY, Kloess S, Bremm M, Ullrich E, Soerensen J, Quaiser A, Erben S, Wunram C, Gardlowski T, Auth E, Tonn T, Seidl C, Meyer-Monard S, Stern M, Passweg J, Klingebiel T, Bader P, Schwabe D, Esser R
  
• Clinical grade purification and expansion of NK cell products for an optimized manufacturing protocol. Front Oncol. 2013 May 17;3:118
  Koehl U, Brehm C, Huenecke S, Zimmermann SY, Kloess S, Bremm M, Ullrich E, Soerensen J, Quaiser A, Erben S, Wunram C, Gardlowski T, Auth E, Tonn T, Seidl C, Meyer-Monard S, Stern M, Passweg J, Klingebiel T, Bader P, Schwabe D, Esser R
  
• Clinical grade purification and expansion of NK cell products for an optimized manufacturing protocol. Front Oncol. 2013 May 17;3:118
  Koehl U, Brehm C, Huenecke S, Zimmermann SY, Kloess S, Bremm M, Ullrich E, Soerensen J, Quaiser A, Erben S, Wunram C, Gardlowski T, Auth E, Tonn T, Seidl C, Meyer-Monard S, Stern M, Passweg J, Klingebiel T, Bader P, Schwabe D, Esser R
  
• Clinical grade purification and expansion of NK cell products for an optimized manufacturing protocol. Front Oncol. 2013;3:118
  Koehl U, Brehm C, Huenecke S, Zimmermann SY, Kloess S, Bremm M, Ullrich E, Soerensen J, Quaiser A, Erben S, Wunram C, Gardlowski T, Auth E, Tonn T, Seidl C, Meyer-Monard S, Stern M, Passweg J, Klingebiel T, Bader P, Schwabe D, Esser R
  
• CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation. J Immunol. 2013 Apr 1;190(7):3696-705
  Giegold O, Ogrissek N, Richter C, Schröder M, Herrero San Juan M, Pfeilschifter JM, Radeke HH
  
• CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation. J Immunol. 2013 Apr 1;190(7):3696-705
  Giegold O, Ogrissek N, Richter C, Schröder M, Herrero San Juan M, Pfeilschifter JM, Radeke HH
  
• CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation. J Immunol. 2013 Apr 1;190(7):3696-705
  Giegold O, Ogrissek N, Richter C, Schröder M, Herrero San Juan M, Pfeilschifter JM, Radeke HH
  
• CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation. J Immunol. 2013 Apr 1;190(7):3696-705
  Giegold O, Ogrissek N, Richter C, Schröder M, Herrero San Juan M, Pfeilschifter JM, Radeke HH
  
• Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity. Biochem Pharmacol. 2013 Jul 15;86(2):286-96
  Kahnt AS, Rörsch F, Diehl O, Hofmann B, Lehmann C, Steinbrink SD, Angioni C, Geisslinger G, Grösch S, Steinhilber D, Maier TJ
  
• Diagnostic and prognostic significance of cell death and macrophage activation markers in patients with hepatocellular carcinoma. J Hepatol. 2013 Oct;59(4):769-79
  Waidmann O, Köberle V, Bettinger D, Trojan J, Zeuzem S, Schultheiß M, Kronenberger B, Piiper A
  
• Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers. PLoS One. 2013 Sep 20;8(9):e75184
  Köberle V, Pleli T, Schmithals C, Augusto Alonso E, Haupenthal J, Bönig H, Peveling-Oberhag J, Biondi RM, Zeuzem S, Kronenberger B, Waidmann O, Piiper A
  
• Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers. PLoS One. 2013 Sep 20;8(9):e75184
  Köberle V, Pleli T, Schmithals C, Augusto Alonso E, Haupenthal J, Bönig H, Peveling-Oberhag J, Biondi RM, Zeuzem S, Kronenberger B, Waidmann O, Piiper A
  
• Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers. PLoS One. 2013 Sep 20;8(9):e75184
  Köberle V, Pleli T, Schmithals C, Augusto Alonso E, Haupenthal J, Bönig H, Peveling-Oberhag J, Biondi RM, Zeuzem S, Kronenberger B, Waidmann O, Piiper A
  
• Displaying high-affinity ligands on adeno-associated viral vectors enables tumor cell-specific and safe gene transfer. Mol Ther. 2013 Jan;21(1):109-18
  Münch RC, Janicki H, Völker I, Rasbach A, Hallek M, Büning H, Buchholz CJ
  
• EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells. PLoS One. 2013;8(4):e61267
  Oberoi P, Jabulowsky RA, Bähr-Mahmud H, Wels WS
  
• EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells. PLoS One. 2013;8(4):e61267
  Oberoi P, Jabulowsky RA, Bähr-Mahmud H, Wels WS
  
• EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells. PLoS One. 2013;8(4):e61267
  Oberoi P, Jabulowsky RA, Bähr-Mahmud H, Wels WS
  
• From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease. Hum Gene Ther Clin Dev. 2013 Jun;24(2):86-98
  Stein S, Scholz S, Schwäble J, Sadat MA, Modlich U, Schultze-Strasser S, Diaz M, Chen-Wichmann L, Müller-Kuller U, Brendel C, Fronza R, Kaufmann KB, Naundorf S, Pech NK, Travers JB, Matute JD, Presson RG Jr, Sandusky GE, Kunkel H, Rudolf E, Dillmann A, von Kalle C, Kühlcke K, Baum C, Schambach A, Dinauer MC, Schmidt M, Grez M
  
• From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease. Hum Gene Ther Clin Dev. 2013 Jun;24(2):86-98
  Stein S, Scholz S, Schwäble J, Sadat MA, Modlich U, Schultze-Strasser S, Diaz M, Chen-Wichmann L, Müller-Kuller U, Brendel C, Fronza R, Kaufmann KB, Naundorf S, Pech NK, Travers JB, Matute JD, Presson RG Jr, Sandusky GE, Kunkel H, Rudolf E, Dillmann A, von Kalle C, Kühlcke K, Baum C, Schambach A, Dinauer MC, Schmidt M, Grez M
  
• From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease. Hum Gene Ther Clin Dev. 2013 Jun;24(2):86-98
  Stein S, Scholz S, Schwäble J, Sadat MA, Modlich U, Schultze-Strasser S, Diaz M, Chen-Wichmann L, Müller-Kuller U, Brendel C, Fronza R, Kaufmann KB, Naundorf S, Pech NK, Travers JB, Matute JD, Presson RG Jr, Sandusky GE, Kunkel H, Rudolf E, Dillmann A, von Kalle C, Kühlcke K, Baum C, Schambach A, Dinauer MC, Schmidt M, Grez M
  
• Gene therapy on the move. EMBO Mol Med. 2013 Nov;5(11):1642-61
  Kaufmann KB, Büning H, Galy A, Schambach A, Grez M
  
• High Serum Levels of the Interleukin-33 Receptor Soluble ST2 as a Negative Prognostic Factor in Hepatocellular Carcinoma. Transl Oncol. 2013 Jun 1;6(3):311-8
  Bergis D, Kassis V, Ranglack A, Koeberle V, Piiper A, Kronenberger B, Zeuzem S, Waidmann O, Radeke HH
  
• Highlights of the third International Conference on Immunotherapy in Pediatric Oncology. Pediatr Hematol Oncol. 2013 Aug;30(5):349-66
  Brehm C, Huenecke S, Pfirrmann V, Rossig C, Mackall CL, Bollard CM, Gottschalk S, Schlegel PG, Klingebiel T, Bader P
  
• Highlights of the third International Conference on Immunotherapy in Pediatric Oncology. Pediatr Hematol Oncol. 2013 Aug;30(5):349-66
  Brehm C, Huenecke S, Pfirrmann V, Rossig C, Mackall CL, Bollard CM, Gottschalk S, Schlegel PG, Klingebiel T, Bader P
  
• Highlights of the third International Conference on Immunotherapy in Pediatric Oncology. Pediatr Hematol Oncol. 2013; 30(5):349-66
  Brehm C, Huenecke S, Pfirrmann V, Rossig C, Mackall CL, Bollard CM, Gottschalk S, Schlegel PG, Klingebiel T, Bader P
  
• Identification of a new epitope for HIV-neutralizing antibodies in the gp41 membrane proximal external region by an Env-tailored phage display library. Eur J Immunol. 2013 Feb; 43(2):499-509
  Zhou M, Meyer T, Koch S, Koch J, von Briesen H, Benito JM, Soriano V, Haberl A, Bickel M, Dübel S, Hust M, Dietrich U
  
• IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets. Biochem Pharmacol. 2013 Feb 1;85(3):396-403
  Bachmann M, Ulziibat S, Härdle L, Pfeilschifter J, Mühl H
  
• IL-22 in tissue-protective therapy. Br J Pharmacol. 2013 Jun;169(4):761-71
  Mühl H, Scheiermann P, Bachmann M, Härdle L, Heinrichs A, Pfeilschifter J
  
• IL-22 in tissue-protective therapy. Br J Pharmacol. 2013 Jun;169(4):761-71
  Muehl H, Scheiermann P, Bachmann M, Härdle L, Heinrichs A, Pfeilschifter J
  
• Influence of the vitamin D plasma level and vitamin D-related genetic polymorphisms on the immune status of patients with type 1 diabetes: a pilot study. Clin Exp Immunol. 2013 Feb;171(2):171-85
  Rose K, Penna-Martinez M, Klahold E, Kärger D, Shoghi F, Kahles H, Bayer M, Hintermann E, Pfeilschifter JM, Badenhoop K, Ramos-Lopez E, Christen U
  
• Interference with RUNX1/ETO leukemogenic function by cell-penetrating peptides targeting the NHR2 oligomerization domain. Biomed Res Int. 013;2013:297692
  Bartel Y, Grez M, Wichmann C
  
• Intrahepatic application of suicide gene-armed measles virotherapeutics: a safety study in transgenic mice and rhesus macaques. Hum Gene Ther Clin Dev. 2013 Mar;24(1):11-22
  Völker I, Bach P, Coulibaly C, Plesker R, Abel T, Seifried J, Heidmeier S, Muehlebach MD, Lauer UM, Buchholz CJ
  
• Lipid peroxidation in multidrug-resistant Gram-negative sepsis: translating science to the septic patient? Crit Care. 2013 Mar 1;17(2):120
  Scheiermann P, Pischke SE
  
• Mature T-cell lymphomagenesis induced by retroviral insertional activation of Janus kinase 1. Mol Ther. 2013 Jun;21(6):1160-8
  Heinrich T, Rengstl B, Muik A, Petkova M, Schmid F, Wistinghausen R, Warner K, Crispatzu G, Hansmann ML, Herling M, von Laer D, Newrzela S
  
• MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients. Neoplasia. 2013 Feb;15(2):218-30
  Doberstein K, Steinmeyer N, Hartmetz AK, Eberhardt W, Mittelbronn M, Harter PN, Juengel E, Blaheta R, Pfeilschifter J, Gutwein P
  
• MicroRNA-145 targets the metalloprotease ADAM17 and is suppressed in renal cell carcinoma patients. Neoplasia. 2013 Feb;15(2):218-30
  Doberstein K, Steinmeyer N, Hartmetz AK, Eberhardt W, Mittelbronn M, Harter PN, Juengel E, Blaheta R, Pfeilschifter J, Gutwein P
  
• Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice. Pain. 2013 Mar;154(3):368-76
  Kynast KL, Russe OQ, Möser CV, Geisslinger G, Niederberger E
  
• Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice. Pain. 2013 Mar;154(3):368-76
  Kynast KL, Russe OQ, Möser CV, Geisslinger G, Niederberger E
  
• Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice. Pain. 2013 Mar;154(3):368-76
  Kynast KL, Russe OQ, Möser CV, Geisslinger G, Niederberger E
  
• No effect of antifungal compounds on functional properties of human antifungal T-helper type 1 cells. Transpl Infect Dis. 2013 Aug;15(4):430-4
  Tramsen L, Schmidt S, Koehl U, Huenecke S, Latgé JP, Roeger F, Schubert R, Klingebiel T, Lehrnbecher T
  
• Novel findings in pain processing pathways: implications for miRNAs as future therapeutic targets. Expert Rev Neurother. 2013 May;13(5):515-25
  Kynast KL, Russe OQ, Geisslinger G, Niederberger E
  
• Novel findings in pain processing pathways: implications for miRNAs as future therapeutic targets. Expert Rev Neurother. 2013 May;13(5):515-25
  Kynast KL, Russe OQ, Geisslinger G, Niederberger E
  
• Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms. Oncogene. 2013 May 16;32(20):2586-91
  Eißmann M, Melzer IM, Fernández SB, Michel G, Hrabě de Angelis M, Hoefler G, Finkenwirth P, Jauch A, Schoell B, Grez M, Schmidt M, Bartholomae CC, Newrzela S, Haetscher N, Rieger MA, Zachskorn C, Mittelbronn M, Zörnig M
  
• Regulation of miR-17-92a cluster processing by the microRNA binding protein SND1. FEBS Lett. 2013 Aug 2;587(15):2405-11
  Heinrich EM, Wagner J, Krüger M, John D, Uchida S, Weigand JE, Suess B, Dimmeler S
  
• Response to comment on “CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation”. J Immunol. 2013 Jul 15;191(2):525-6
  Giegold O, Ogrissek N, Radeke HH
  
• Response to comment on “CXCL9 causes heterologous desensitization of CXCL12-mediated memory T lymphocyte activation”. J Immunol. 2013 Jul 15;191(2):525-6
  Giegold O, Ogrissek N, Radeke HH
  
• Selection and characterisation of FVIII-specific single chain variable fragments. Hamostaseologie. 2013;33 Suppl 1:S39-45
  Naumann A, Scherger AK, Neuwirth J, Orlowski A, Kahle J, Schwabe D, Königs C
  
• Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma. Eur J Cancer. 2013 Nov;49(16):3442-9
  Köberle V, Kronenberger B, Pleli T, Trojan J, Imelmann E, Peveling-Oberhag J, Welker MW, Elhendawy M, Zeuzem S, Piiper A, Waidmann O
  
• Serum microRNA-122 kinetics in patients with chronic hepatitis C virus infection during antiviral therapy. J Viral Hepat. 2013 Aug;20(8):530-5
  Köberle V, Waidmann O, Kronenberger B, Andrei A, Susser S, Füller C, Perner D, Zeuzem S, Sarrazin C, Piiper A
  
• Specific elimination of CD133+ tumor cells with targeted oncolytic measles virus. Cancer Res. 2013 Jan 15;73(2):865-74
  Bach P, Abel T, Hoffmann C, Gal Z, Braun G, Voelker I, Ball CR, Johnston IC, Lauer UM, Herold-Mende C, Muehlebach MD, Glimm H, Buchholz CJ
  
• Specific gene delivery to liver sinusoidal and artery endothelial cells. Blood. 2013 Sep 19;122(12):2030-8
  Abel T, El Filali E, Waern J, Schneider IC, Yuan Q, Münch RC, Hick M, Warnecke G, Madrahimov N, Kontermann RE, Schüttrumpf J, Müller UC, Seppen J, Ott M, Buchholz CJ
  
• The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS. Int J Biochem Cell Biol. 2013 Jul;45(7):1195-203
  Hartmann D, Wegner MS, Wanger RA, Ferreirós N, Schreiber Y, Lucks J, Schiffmann S, Geisslinger G, Grösch S
  
• The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs. Curr Mol Med. 2013 Aug;13(7):1089-97
  Niederberger E, Möser CV, Kynast KL, Geisslinger G
  
• The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs. Curr Mol Med. 2013 Aug;13(7):1089-97
  Niederberger E, Möser CV, Kynast KL, Geisslinger G
  
• The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 2013 Feb 1;73(3):1180-9
  Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, Zörnig M, MacLeod AR, Spector DL, Diederichs S
  
• The receptor attachment function of measles virus hemagglutinin can be replaced with an autonomous protein that binds Her2/neu while maintaining its fusion-helper function. J Virol. 2013 Jun;87(11):6246-56
  Rasbach A, Abel T, Münch RC, Boller K, Schneider-Schaulies J, Buchholz CJ
  
• The receptor attachment function of measles virus hemagglutinin can be replaced with an autonomous protein that binds Her2/neu while maintaining its fusion-helper function. J Virol. 2013 Jun;87(11):6246-56
  Rasbach A, Abel T, Münch RC, Boller K, Schneider-Schaulies J, Buchholz CJ
  
• The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophages. Oncogene. 2013 Jan 31;32(5):631-40
  Ley S, Weigert A, Weichand B, Henke N, Mille-Baker B, Janssen RA, Brüne B
  
• Transient expression of an LEDGF/p75 chimera retargets lentivector integration and functionally rescues in a model for X-CGD. Mol Ther Nucleic Acids. 2013 Mar 5;2:e77
  Vets S, De Rijck J, Brendel C, Grez M, Bushman F, Debyser Z, Gijsbers R
  
• Vaccination directed against the human endogenous retrovirus-K envelope protein inhibits tumor growth in a murine model system. PLoS One. 2013 Aug 30;8(8):e72756
  Kraus B, Fischer K, Büchner SM, Wels WS, Löwer R, Sliva K, Schnierle BS
  
• 5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia. Cancer Res. 2014 Sep 15;74(18):5244-55
  Roos J, Oancea C, Heinssmann M, Khan D, Held H, Kahnt AS, Capelo R, la Buscató E, Proschak E, Puccetti E, Steinhilber D, Fleming I, Maier TJ, Ruthardt M
  
• A bispecific transmembrane antibody simultaneously targeting intra- and extracellular epitopes of the epidermal growth factor receptor inhibits receptor activation and tumor cell growth. Int J Cancer. 2014 Jun 1;134(11):2547-59
  Müller N, Hartmann C, Genssler S, Koch J, Kinner A, Grez M, Wels WS
  
• A neutralization assay for chikungunya virus infections in a multiplex format. J Virol Methods. 2014 Jun;201:7-12
  Weber C, König R, Niedrig M, Emmerich P, Schnierle BS
  
• Antigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers. Retrovirology. 2014 May 30;11:42
  Arnold P, Himmels P, Weiß S, Decker TM, Markl J, Gatterdam V, Tampé R, Bartholomäus P, Dietrich U, Dürr R
  
• Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L. Cell Death Dis. 2014 Jul 10;5:e1321
  Winkler C, Doller A, Imre G, Badawi A, Schmid T, Schulz S, Steinmeyer N, Pfeilschifter J, Rajalingam K, Eberhardt W
  
• Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury. Matrix Biol. 2014 Apr;35:143-51
  Moreth K, Frey H, Hubo M, Zeng-Brouwers J, Nastase MV, Hsieh LT, Haceni R, Pfeilschifter J, Iozzo RV, Schaefer L
  
• Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury. Matrix Biol. 2014 Apr;35:143-51
  Moreth K, Frey H, Hubo M, Zeng-Brouwers J, Nastase MV, Hsieh LT, Haceni R, Pfeilschifter J, Iozzo RV, Schaefer L
  
• Biodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imaging. Eur J Pharm Biopharm. 2014 May;87(1):132-41
  Watcharin W, Schmithals C, Pleli T, Köberle V, Korkusuz H, Huebner F, Zeuzem S, Korf HW, Vogl TJ, Rittmeyer C, Terfort A, Piiper A, Gelperina S, Kreuter J
  
• Biodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imaging. Eur J Pharm Biopharm. 2014 May;87(1):132-41
  Watcharin W, Schmithals C, Pleli T, Köberle V, Korkusuz H, Huebner F, Zeuzem S, Korf HW, Vogl TJ, Rittmeyer C, Terfort A, Piiper A, Gelperina S, Kreuter J
  
• Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells. Biochem Pharmacol. 2014 Oct 22;92(4):577-589
  Wegner MS, Wanger RA, Oertel S, Brachtendorf S, Hartmann D, Schiffmann S, Marschalek R, Schreiber Y, Ferreirós N, Geisslinger G, Grösch S
  
• Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol. 2014 Apr 1;88(3):313-21
  Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B
  
• Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol. 2014; 88(3):313-21
  Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B
  
• Chiral chromatographytandem mass spectrometry applied to thedetermination of pro-resolving lipid mediators. J Chromatogr A. 2014 Sep 19;1360:150-63
  Homann J, Lehmann C, Kahnt AS, Steinhilber D, Parnham MJ, Geisslinger G, Ferreirós N
  
• Commentary: vitamin D deficiency and liver cancer - cause, effect or myth? Authors’ reply. Aliment Pharmacol Ther. 2014 Jun;39(12):1429-30
  Finkelmeier F, Kronenberger B, Köberle V, Bojunga J, Zeuzem S, Trojan J, Piiper A, Waidmann O
  
• De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways. Matrix Biol. 2014 Apr;35:132-42
  Zeng-Brouwers J, Beckmann J, Nastase MV, Iozzo RV, Schaefer L
  
• Dendritic cell reconstitution is associated with relapse-free survival and acute GVHD severity in children after allogeneic stem cell transplantation. Bone Marrow Transplant. 2014 Nov 10
  Elze MC, Ciocarlie O, Heinze A, Kloess S, Gardlowski T, Esser R, Klingebiel T, Bader P, Huenecke S, Serban M, Koehl U, Hutton JL
  
• EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma. Hepatology. 2014 May;59(5):1886-99
  Pellegrino R, Calvisi DF, Neumann O, Kolluru V, Wesely J, Chen X, Wang C, Wuestefeld T, Ladu S, Elgohary N, Bermejo JL, Radlwimmer B, Zörnig M, Zender L, Dombrowski F, Evert M, Schirmacher P, Longerich T
  
• Endotoxin depletion of recombinant protein preparations through their preferential binding to histidine tags. Anal Biochem. 2014 Dec 1;466:83-8
  Mack L, Brill B, Delis N, Groner B
  
• Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations. Stem Cells Dev. 2014 Apr 1;23(7):755-66
  Ungerer C, Quade-Lyssy P, Radeke HH, Henschler R, Königs C, Koehl U, Seifried E, Schüttrumpf J
  
• Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations. Stem Cells Dev. 2014 Apr 1;23(7):755-66
  Ungerer C, Quade-Lyssy P, Radeke HH, Henschler R, Königs C, Koehl U, Seifried E, Schüttrumpf J
  
• Gene therapy for chronic granulomatous disease: current status and future perspectives. Curr Gene Ther. 2014;14(6):447-60
  Kaufmann KB, Chiriaco M, Siler U, Finocchi A, Reichenbach J, Stein S, Grez M
  
• Generation of X-CGD cells for vector evaluation from healthy donor CD34(+) HSCs by shRNA-mediated knock down of gp91(phox). Mol Ther Methods Clin Dev. 2014 Aug 27;1:14037
  Brendel C, Kaufmann KB, Krattenmacher A, Pahujani S, Grez M
  
• Generation of X-CGD cells for vector evaluation from healthy donor CD34(+) HSCs by shRNA-mediated knock down of gp91(phox). Mol Ther Methods Clin Dev. 2014 Aug 27;1:14037
  Brendel C, Kaufmann KB, Krattenmacher A, Pahujani S, Grez M
  
• Inflammatory conditions induce IRES-dependent translation of cyp24a1. PLoS One. 2014 Jan 8;9(1):e85314
  Rübsamen D, Kunze MM, Buderus V, Brauß TF, Bajer MM, Brüne B, Schmid T
  
• Inflammatory conditions induce IRES-dependent translation of cyp24a1. PLoS One. 2014; 9(1):e85314
  Rübsamen D, Kunze MM, Buderus V, Brauß TF, Bajer MM, Brüne B, Schmid T
  
• Interleukin-2-stimulated natural killer cells are less susceptible to mycophenolate mofetil than non-activated NK cells: possible consequences for immunotherapy. Cancer Immunol Immunother. 2014 Aug;63(8):821-33
  Brehm C, Huenecke S, Esser R, Kloess S, Quaiser A, Betz S, Zimmermann O, Soerensen J, Passweg JR, Klingebiel T, Schwabe D, Bader P, Koehl U
  
• Interleukin-2-stimulated natural killer cells are less susceptible to mycophenolate mofetil than non-activated NK cells: possible consequences for immunotherapy. Cancer Immunol Immunother. 2014; 63(8):821-33
  Brehm C, Huenecke S, Esser R, Kloess S, Quaiser A, Betz S, Zimmermann O, Soerensen J, Passweg JR, Klingebiel T, Schwabe D, Bader P, Koehl U
  
• Interleukin-22 serum levels are a negative prognostic indicator in patients with hepatocellular carcinoma. Hepatology. 2014 Mar;59(3):1207
  Waidmann O, Kronenberger B, Scheiermann P, Köberle V, Muehl H, Piiper A
  
• Interleukin-22 serum levels are a negative prognostic indicator in patients with hepatocellular carcinoma. Hepatology. 2014 Mar;59(3):1207
  Waidmann O, Kronenberger B, Scheiermann P, Köberle V, Mühl H, Piiper A
  
• Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology. Biochim Biophys Acta. 2014 Aug;1840(8):2460-70
  Nastase MV, Iozzo RV, Schaefer L
  
• Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity. Neuropathol Appl Neurobiol. 2014 Feb;40(2):205-16
  Baumgarten P, Harter PN, Tönjes M, Capper D, Blank AE, Sahm F, von Deimling A, Kolluru V, Schwamb B, Rabenhorst U, Starzetz T, Kögel D, Rieker RJ, Plate KH, Ohgaki H, Radlwimmer B, Zörnig M, Mittelbronn M
  
• Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity. Neuropathol Appl Neurobiol. 2014 Feb;40(2):205-16
  Baumgarten P, Harter PN, Tönjes M, Capper D, Blank AE, Sahm F, von Deimling A, Kolluru V, Schwamb B, Rabenhorst U, Starzetz T, Kögel D, Rieker RJ, Plate KH, Ohgaki H, Radlwimmer B, Zörnig M, Mittelbronn M
  
• LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR. Biochem Biophys Res Commun. 2014 May 9;447(3):520-5
  Russe OQ, Möser CV, Kynast KL, King TS, Olbrich K, Grösch S, Geisslinger G, Niederberger E
  
• LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR. Biochem Biophys Res Commun. 2014 May 9;447(3):520-5
  Russe OQ, Möser CV, Kynast KL, King TS, Olbrich K, Grösch S, Geisslinger G, Niederberger E
  
• LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR. Biochem Biophys Res Commun. 2014 May 9;447(3):520-5
  Russe OQ, Möser CV, Kynast KL, King TS, Olbrich K, Grösch S, Geisslinger G, Niederberger E
  
• LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR. Biochem Biophys Res Commun. 2014 May 9;447(3):520-5
  Russe OQ, Möser CV, Kynast KL, King TS, Olbrich K, Grösch S, Geisslinger G, Niederberger E
  
• Modulation of IL-33/ST2-TIR and TLR Signalling Pathway by Fingolimod and Analogues in Immune Cells. Scand J Immunol. 2014 Dec;80(6):398-407
  Rüger K, Ottenlinger F, Schröder M, Zivković A, Stark H, Pfeilschifter JM, Radeke HH
  
• Multimer monitoring of CMV-specific T cells in research and in clinical applications. Diagn Microbiol Infect Dis. 2014 Mar;78(3):201-12
  Borchers S, Ogonek J, Varanasi PR, Tischer S, Bremm M, Eiz-Vesper B, Koehl U, Weissinger EM
  
• Next generation FIX muteins with FVIII-independent activity for alternative treatment of hemophilia A. J Thromb Haemost. 2014 Nov;12(11):1861-73
  Quade-Lyssy P, Abriss D, Milanov P, Ungerer C, Königs C, Seifried E, Schüttrumpf J
  
• Next generation FIX muteins with FVIII-independent activity for alternative treatment of hemophilia A. J Thromb Haemost. 2014 Nov;12(11):1861-73
  Quade-Lyssy P, Abriss D, Milanov P, Ungerer C, Königs C, Seifried E, Schüttrumpf J
  
• Next generation FIX muteins with FVIII-independent activity for alternative treatment of hemophilia A. J Thromb Haemost. 2014 Nov;12(11):1861-73
  Quade-Lyssy P, Abriss D, Milanov P, Ungerer C, Königs C, Seifried E, Schüttrumpf J
  
• Oral gene therapy for hemophilia B using chitosan-formulated FIX mutants. J Thromb Haemost. 2014 Jun;12(6):932-42
  Quade-Lyssy P, Milanov P, Abriss D, Ungerer C, Königs C, Seifried E, Schüttrumpf J
  
• Oral gene therapy for hemophilia B using chitosan-formulated FIX mutants. J Thromb Haemost. 2014 Jun;12(6):932-42
  Quade-Lyssy P, Milanov P, Abriss D, Ungerer C, Königs C, Seifried E, Schüttrumpf J
  
• Oral gene therapy for hemophilia B using chitosan-formulated FIX mutants. J Thromb Haemost. 2014 Jun;12(6):932-42
  Quade-Lyssy P, Milanov P, Abriss D, Ungerer C, Königs C, Seifried E, Schüttrumpf J
  
• Overexpression of far upstream element (FUSE) binding protein (FBP)-interacting repressor (FIR) supports growth of hepatocellular carcinoma. Hepatology. 2014 Oct;60(4):1241-50
  Malz M, Bovet M, Samarin J, Rabenhorst U, Sticht C, Bissinger M, Roessler S, Bermejo JL, Renner M, Calvisi DF, Singer S, Ganzinger M, Weber A, Gretz N, Zörnig M, Schirmacher P, Breuhahn K
  
• PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis. Biochem Pharmacol. 2014 Feb 15;87(4):625-35
  Schiffmann S, Weigert A, Männich J, Eberle M, Birod K, Häussler A, Ferreiros N, Schreiber Y, Kunkel H, Grez M, Weichand B, Brüne B, Pfeilschifter W, Nüsing R, Niederberger E, Grösch S, Scholich K, Geisslinger G
  
• Physico-chemical and toxicological characterization of iron-containing albumin nanoparticles as platforms for medical imaging. J Control Release. 2014 Nov 28;194:130-7
  Rosenberger I, Schmithals C, Vandooren J, Bianchessi S, Milani P, Locatelli E, Israel LL, Hübner F, Matteoli M, Lellouche JP, Franchini MC, Passoni L, Scanziani E, Opdenakker G, Piiper A, Kreuter J
  
• Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages. Pain. 2014 Mar;155(3):545-55
  Schuh CD, Pierre S, Weigert A, Weichand B, Altenrath K, Schreiber Y, Ferreiros N, Zhang DD, Suo J, Treutlein EM, Henke M, Kunkel H, Grez M, Nüsing R, Brüne B, Geisslinger G, Scholich K
  
• Re-engineering vesicular stomatitis virus to abrogate neurotoxicity, circumvent humoral immunity, and enhance oncolytic potency. Cancer Res. 2014 Jul 1;74(13):3567-78
  Muik A, Stubbert LJ, Jahedi RZ, Geiβ Y, Kimpel J, Dold C, Tober R, Volk A, Klein S, Dietrich U, Yadollahi B, Falls T, Miletic H, Stojdl D, Bell JC, von Laer D
  
• Re-engineering vesicular stomatitis virus to abrogate neurotoxicity, circumvent humoral immunity, and enhance oncolytic potency. Cancer Res. 2014 Jul 1;74(13):3567-78
  Muik A, Stubbert LJ, Jahedi RZ, Geiβ Y, Kimpel J, Dold C, Tober R, Volk A, Klein S, Dietrich U, Yadollahi B, Falls T, Miletic H, Stojdl D, Bell JC, von Laer D
  
• Re-engineering vesicular stomatitis virus to abrogate neurotoxicity, circumvent humoral immunity, and enhance oncolytic potency. Cancer Res. 2014 Jul 1;74(13):3567-78
  Muik A, Stubbert LJ, Jahedi RZ, Geiβ Y, Kimpel J, Dold C, Tober R, Volk A, Klein S, Dietrich U, Yadollahi B, Falls T, Miletic H, Stojdl D, Bell JC, von Laer D
  
• Resveratrol posttranscriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity. Nucleic Acids Res. 2014 Nov 10;42(20):12555-69
  Bollmann F, Art J, Henke J, Schrick K, Besche V, Bros M, Li H, Siuda D, Handler N, Bauer F, Erker T, Behnke F, Mönch B, Härdle L, Hoffmann M, Chen CY, Förstermann U, Dirsch VM, Werz O, Kleinert H, Pautz A
  
• Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor. Mol Ther. 2014 Nov 6
  Schönfeld K, Sahm C, Zhang C, Naundorf S, Brendel C, Odendahl M, Nowakowska P, Bönig H, Koehl U, Kloess S, Koehler S, Holtgreve-Grez H, Jauch A, Schmidt M, Schubert R, Kühlcke K, Seifried E, Klingemann HG, Rieger MA, Tonn T, Grez M, Wels WS
  
• Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells. PLoS One. 2014 Dec 26;9(12):e116114
  Bayin NS, Modrek AS, Dietrich A, Lebowitz J, Abel T, Song HR, Schober M, Zagzag D, Buchholz CJ, Chao MV, Placantonakis DG
  
• Serum autotaxin is a parameter for the severity of liver cirrhosis and overall survival in patients with liver cirrhosis--a prospective cohort study. PLoS One. 2014 Jul 25;9(7):e103532
  Pleli T, Martin D, Kronenberger B, Brunner F, Köberle V, Grammatikos G, Farnik H, Martinez Y, Finkelmeier F, Labocha S, Ferreirós N, Zeuzem S, Piiper A, Waidmann O
  
• Severe 25-hydroxyvitamin D deficiency identifies a poor prognosis in patients with hepatocellular carcinoma - a prospective cohort study. Aliment Pharmacol Ther. 2014 May;39(10):1204-12
  Finkelmeier F, Kronenberger B, Köberle V, Bojunga J, Zeuzem S, Trojan J, Piiper A, Waidmann O
  
• Single measurement of hemoglobin predicts outcome of HCC patients. Med Oncol. 2014 Jan;31(1):806
  Finkelmeier F, Bettinger D, Köberle V, Schultheiß M, Zeuzem S, Kronenberger B, Piiper A, Waidmann O
  
• SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy. Front Pediatr. 2014 Jul 18;2:75
  Rettinger E, Glatthaar A, Abhari BA, Oelsner S, Pfirrmann V, Huenecke S, Kuçi S, Kreyenberg H, Willasch AM, Klingebiel T, Fulda S, Bader P
  
• SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy. Front Pediatr. 2014 Jul 18;2:75
  Rettinger E, Glatthaar A, Abhari BA, Oelsner S, Pfirrmann V, Huenecke S, Kuçi S, Kreyenberg H, Willasch AM, Klingebiel T, Fulda S, Bader P
  
• SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy. Front Pediatr. 2014 Jul 18;2:75
  Rettinger E, Glatthaar A, Abhari BA, Oelsner S, Pfirrmann V, Huenecke S, Kuçi S, Kreyenberg H, Willasch AM, Klingebiel T, Fulda S, Bader P
  
• Soluble biglycan as a biomarker of inflammatory renal diseases. Int J Biochem Cell Biol. 2014 Sep;54:223-35
  Hsieh LT, Nastase MV, Zeng-Brouwers J, Iozzo RV, Schaefer L
  
• Soluble biglycan as a biomarker of inflammatory renal diseases. Int J Biochem Cell Biol. 2014 Sep;54:223-35
  Hsieh LT, Nastase MV, Zeng-Brouwers J, Iozzo RV, Schaefer L
  
• Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo. Cell Physiol Biochem. 2014;34(1):27-44
  Arlt O, Schwiebs A, Japtok L, Rüger K, Katzy E, Kleuser B, Radeke HH
  
• Targeting survivin in cancer: novel drug development approaches. BioDrugs. 2014 Feb;28(1):27- 39
  Groner B, Weiss A
  
• Vaccination directed against the human endogenous retrovirus-K (HERV-K) gag protein slows HERV-K gag expressing cell growth in a murine model system. Virol J. 2014 Mar 26;11:58
  Kraus B, Fischer K, Sliva K, Schnierle BS
  
• VSV-GP: a potent viral vaccine vector that boosts the immune response upon repeated applications. J Virol. 2014 May;88(9):4897-907
  Tober R, Banki Z, Egerer L, Muik A, Behmüller S, Kreppel F, Greczmiel U, Oxenius A, von Laer D, Kimpel J
  
• VSV-GP: a potent viral vaccine vector that boosts the immune response upon repeated applications. J Virol. 2014 May;88(9):4897-907
  Tober R, Banki Z, Egerer L, Muik A, Behmüller S, Kreppel F, Greczmiel U, Oxenius A, von Laer D, Kimpel J
  
• 5-lipoxygenase is a direct target of miR- 19a-3p and miR-125b-5p. J Immunol. 2015 Feb 15;194(4):1646-53
  Busch S, Auth E, Scholl F, Huenecke S, Koehl U, Suess B, Steinhilber D
  
• 5-lipoxygenase is a direct target of miR- 19a-3p and miR-125b-5p. J Immunol. 2015 Feb 15;194(4):1646-53
  Busch S, Auth E, Scholl F, Huenecke S, Koehl U, Suess B, Steinhilber D
  
• A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells. Nucleic Acids Res. 2015 Feb 18;43(3):1577-92
  Müller-Kuller U, Ackermann M, Kolodziej S, Brendel C, Fritsch J, Lachmann N, Kunkel H, Lausen J, Schambach A, Moritz T, Grez M
  
• A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway. Immunol Cell Biol. 2015 Apr;93(4):396-405
  Helling B, König M, Dälken B, Engling A, Krömer W, Heim K, Wallmeier H, Haas J, Wildemann B, Fritz B, Jonuleit H, Kubach J, Dingermann T, Radeke HH, Osterroth F, Uherek C, Czeloth N, Schüttrumpf J
  
• A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway. Immunol Cell Biol. 2015 Apr;93(4):396-405
  Helling B, König M, Dälken B, Engling A, Krömer W, Heim K, Wallmeier H, Haas J, Wildemann B, Fritz B, Jonuleit H, Kubach J, Dingermann T, Radeke HH, Osterroth F, Uherek C, Czeloth N, Schüttrumpf J
  
• Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors. Leukemia. 2015 Feb;29(2):279-89
  Wichmann C, Quagliano-Lo Coco I, Yildiz Ö, Chen-Wichmann L, Weber H, Syzonenko T, Döring C, Brendel C, Ponnusamy K, Kinner A, Brandts C, Henschler R, Grez M
  
• Activation of AMPK and its impact on exercise capacity. Sports Med. 2015 Nov;45(11):1497-509
  Niederberger E, King TS, Russe OQ, Geisslinger G
  
• AMP-activated protein kinase is activated by non-steroidal anti-inflammatory drugs. Eur J Pharmacol. 2015 Sep 5;762:299-305
  King TS, Russe OQ, Möser CV, Ferreirós N, Kynast KL, Knothe C, Olbrich K, Geisslinger G, Niederberger E
  
• Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminopheninduced liver injury. Sci Rep. 2015 Feb 17;5:8521
  Scheiermann P, Bachmann M, Härdle L, Pleli T, Piiper A, Zwissler B, Pfeilschifter J, Mühl H
  
• Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminopheninduced liver injury. Sci Rep. 2015 Feb 17;5:8521
  Scheiermann P, Bachmann M, Härdle L, Pleli T, Piiper A, Zwissler B, Pfeilschifter J, Mühl H
  
• CD105 is a surface marker for receptor-targeted gene transfer into human long-term repopulating hematopoietic stem cells. Stem Cells Dev. 2015 Mar 15;24(6):714-23
  Kays SK, Kaufmann KB, Abel T, Brendel C, Bonig H, Grez M, Buchholz CJ, Kneissl S
  
• CD105 is a surface marker for receptor-targeted gene transfer into human long-term repopulating hematopoietic stem cells. Stem Cells Dev. 2015 Mar 15;24(6):714-23
  Kays SK, Kaufmann KB, Abel T, Brendel C, Bonig H, Grez M, Buchholz CJ, Kneissl S
  
• CD133-targeted Gene Transfer Into Long-term Repopulating Hematopoietic Stem Cells. Mol Ther. 2015 Jan;23(1):63-70
  Brendel C, Goebel B, Daniela A, Brugman M, Kneissl S, Schwäble J, Kaufmann KB, Müller-Kuller U, Kunkel H, Chen-Wichmann L, Abel T, Serve H, Bystrykh L, Buchholz CJ, Grez M
  
• CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells. Mol Ther. 2015 Jan;23(1):63-70. Erratum in: Mol Ther. 2015 Apr;23(4):790
  Brendel C, Goebel B, Daniela A, Brugman M, Kneissl S, Schwäble J, Kaufmann KB, Müller-Kuller U, Kunkel H, Chen-Wichmann L, Abel T, Serve H, Bystrykh L, Buchholz CJ, Grez M
  
• Conditional control of mammalian gene expression by tetracyclinedependent hammerhead ribozymes. ACS Synth Biol. 2015 May 15;4(5):526-34
  Beilstein K, Wittmann A, Grez M, Suess B
  
• Conditional control of mammalian gene expression by tetracyclinedependent hammerhead ribozymes. ACS Synth Biol. 2015 May 15;4(5):526-34
  Beilstein K, Wittmann A, Grez M, Suess B
  
• Cytokines induce protein kinase A-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells. Biochem Pharmacol. 2015 Feb 1;93(3):362-9
  Beck KF, Euler J, Eisel F, Beck M, Koehler Y, Sha LK, von Knethen A, Longen S, Pfeilschifter J
  
• Cytomegalovirus-specific cytokine-induced killer cells: concurrent targeting of leukemia and cytomegalovirus. Cytotherapy. 2015 Aug;17(8):1139-51
  Pfirrmann V, Oelsner S, Rettinger E, Huenecke S, Bonig H, Merker M, Wels WS, Cinatl J, Schubert R, Klingebiel T, Bader P
  
• Cytomegalovirus-specific cytokine-induced killer cells: concurrent targeting of leukemia and cytomegalovirus. Cytotherapy. 2015 Aug;17(8):1139-51
  Pfirrmann V, Oelsner S, Rettinger E, Huenecke S, Bonig H, Merker M, Wels WS, Cinatl J, Schubert R, Klingebiel T, Bader P
  
• Detection of hepatocellular carcinoma in transgenic mice by Gd-DTPA- and rhodamine 123-conjugated human serum albumin nanoparticles in T1 magnetic resonance imaging. J Control Release. 2015 Feb 10;199:63-71
  Watcharin W, Schmithals C, Pleli T, Köberle V, Korkusuz H, Hübner F, Waidmann O, Zeuzem S, Korf HW, Terfort A, Gelperina S, Vogl TJ, Kreuter J, Piiper A
  
• Epitope mapping via selection of anti-FVIII antibody-specific phage-presented peptide ligands that mimic the antibody binding sites. Thromb Haemost. 2015 Feb;113(2):396-405
  Kahle J, Orlowski A, Stichel D, Becker-Peters K, Kabiri A, Healey JF, Brettschneider K, Naumann A, Scherger AK, Lollar P, Schwabe D, Königs C
  
• Epitope mapping via selection of anti-FVIII antibody-specific phage-presented peptide ligands that mimic the antibody binding sites. Thromb Haemost. 2015 Feb;113(2):396-405
  Kahle J, Orlowski A, Stichel D, Becker-Peters K, Kabiri A, Healey JF, Brettschneider K, Naumann A, Scherger AK, Lollar P, Schwabe D, Königs C
  
• FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors. Int J Cancer. 2015 Sep 15;137(6):1318-29
  Schwamb B, Pick R, Fernández SB, Völp K, Heering J, Dötsch V, Bösser S, Jung J, Beinoraviciute-Kellner R, Wesely J, Zörnig I, Hammerschmidt M, Nowak M, Penzel R, Zatloukal K, Joos S, Rieker RJ, Agaimy A, Söder S, Reid-Lombardo KM, Kendrick ML, Bardsley MR, Hayashi Y, Asuzu DT, Syed SA, Ordog T, Zörnig M
  
• Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo. J Cell Mol Med. 2015 May;19(5):1021-32
  Fuchs S, Hsieh LT, Saarberg W, Erdelmeier CA, Wichelhaus TA, Schaefer L, Koch E, Fürst R
  
• Improving Drug Penetrability with iRGD Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma. Cancer Res. 2015 Aug 1;75(15):3147-54
  Schmithals C, Köberle V, Korkusuz H, Pleli T, Kakoschky B, Augusto Alonso E, Ibrahim AA, Arencibia JM, Vafaizadeh V, Groner B, Korf HW, Kronenberger B, Zeuzem S, Vogl TJ, Waidmann O, Piiper A
  
• Improving Drug Penetrability with iRGD Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma. Cancer Res. 2015 Aug 1;75(15):3147-54
  Schmithals C, Köberle V, Korkusuz H, Pleli T, Kakoschky B, Augusto-Alonso E, Ibrahim AA, Arencibia JM, Vafaizadeh V, Groner B, Korf HW, Kronenberger B, Zeuzem S, Vogl TJ, Waidmann O, Piiper A
  
• Improving drug penetrability with iRGD leverages the therapeutic response to sorafenib and doxorubicin in hepatocellular carcinoma. Cancer Res. 2015 Aug 1;75(15):3147-54
  Schmithals C, Köberle V, Korkusuz H, Pleli T, Kakoschky B, Augusto Alonso E, Ibrahim AA, Arencibia JM, Vafaizadeh V, Groner B, Korf HW, Kronenberger B, Zeuzem S, Vogl TJ, Waidmann O, Piiper A
  
• In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses. Sci Rep. 2015 Jun 19;5:11434
  Schmier S, Mostafa A, Haarmann T, Bannert N, Ziebuhr J, Veljkovic V, Dietrich U, Pleschka S
  
• Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor. Mol Ther. 2015 Feb;23(2):330-8
  Schönfeld K, Sahm C, Zhang C, Naundorf S, Brendel C, Odendahl M, Nowakowska P, Bönig H, Koehl U, Kloess S, Koehler S, Holtgreve-Grez H, Jauch A, Schmidt M, Schubert R, Kühlcke K, Seifried E, Klingemann HG, Rieger MA, Tonn T, Grez M, Wels WS
  
• Simultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulin. PLoS One. 2015 Mar 10;10(3):e0118802
  Pfarr K, Danciu C, Arlt O, Neske C, Dehelean C, Pfeilschifter JM, Radeke HH
  
• Simultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulin. PLoS One. 2015 Mar 10;10(3):e0118802
  Pfarr K, Danciu C, Arlt O, Neske C, Dehelean C, Pfeilschifter JM, Radeke HH
  
• Simultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulin. PLoS One. 2015 Mar 10;10(3):e0118802
  Pfarr K, Danciu C, Arlt O, Neske C, Dehelean C, Pfeilschifter JM, Radeke HH
  
• Stat5 exerts distinct, vital functions in the cytoplasm and nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL leukemia cells. Cancers (Basel). 2015 Mar 19;7(1):503-37
  Weber A, Borghouts C, Brendel C, Moriggl R, Delis N, Brill B, Vafaizadeh V, Groner B
  
• Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. Biol Chem. 2015 Jun;396(6-7):795-802
  Schröder M, Arlt O, Schmidt H, Huwiler A, Angioni C, Pfeilschifter JM, Schwiebs A, Radeke HH
  
• Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. Biol Chem. 2015 Jun;396(6-7):795-802
  Schröder M, Arlt O, Schmidt H, Huwiler A, Angioni C, Pfeilschifter JM, Schwiebs A, Radeke HH
  
• The effect of neurosphere culture conditions on the cellular metabolism of glioma cells. Folia Neuropathol. 2015;53(3):219-25
  Dietrich U, Koch K, Suwala AK, Hartmann R, Cheng M, Maciaczyk D, Willbold D, Eberhart CG, Glunde K, Maciaczyk J
  
• The green tea catechin, epigallocatechin gallate inhibits chikungunya virus infection. Antiviral Res. 2015 Jan;113C:1-3
  Weber C, Sliva K, von Rhein C, Kümmerer BM, Schnierle BS
  
• The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain. Brain Res. 2015 Oct 22;1624:380-9
  Syhr KM, Boosen M, Hohmann SW, Longen S, Koehler Y, Pfeilschifter J, Beck KF, Geisslinger G, Schmidtko A, Kallenborn-Gerhardt W
  
• Tristetraprolin regulation of interleukin-22 production. Sci Rep. 2015 Oct 21;5:15112
  Härdle L, Bachmann M, Bollmann F, Pautz A, Schmid T, Eberhardt W, Kleinert H, Pfeilschifter J, Mühl H