The mechanism of primary-active transporters, light-driven ion channels and pumps studied by solid-state NMR (P06)

• Subject Area: Structural Biology
• Term: from 2008 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 57566863

For translocating substrates across membranes, transport proteins undergo conformational changes at different times and length scales and often require long-range communication between distant domains. Their function is closely coupled to the membrane environment. We will address the interplay of structure, function and dynamics within the lipid bilayer by applying solid-state NMR methods and biochemical approaches to proteins from the ABC transporter and retinal binding protein families.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 807: Transport and Communication across Biological Membrans
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Clemens Glaubitz