Project Details
Projekt
Regulation of complexes involved in spindle positioning (NW 01)
Subject Area
Cell Biology
Term
from 2008 to 2010
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5485988
The position of the mitotic spindle in polarized cells determines symmetry or asymmetry of cell division. Spindle positioning in asymmetrically dividing S. cerevisiae relies on astral microtubule function and the conserved Kar9 and dynein complexes. Recently, we have identified new modes of Kar9 regulation and a novel role of dynein in spindle assembly. We will continue with our studies on Kar9 ubiquitylation, on the coordination of spindle positioning with spindle assembly and on nuclear envelope dynamics during nuclear migration in yeast.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Head
Dimitris Liakopoulos, Ph.D.
