FOR 1086:  K2P-Channels - From Molecules to Physiology and Pathophysiology

• Subject Area: Medicine
• Term: from 2008 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 66618578

• Final Report Year: 2015

Final Report Abstract

No abstract available

Publications

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• Ci-VSP is a depolarization-activated phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-3,4,5-trisphosphate 5'-phosphatase. Journal of Biological Chemistry, Vol. 284. 2009, pp. 2106-2113.
  Halaszovich C.R., Schreiber D.N., Oliver D.
  (See online at https://dx.doi.org/10.1074/jbc.M803543200)
• Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins. Journal of Physiology, Vol. 587. 2009, Issue 5, pp. 929-952.
  Zuzarte M., Heusser K., Renigunta V., Schlichthörl G., Rinné S., Wischmeyer E., Daut J., Schwappach B., Preisig-Müller R.
  (See online at https://doi.org/10.1113/jphysiol.2008.164756)
• Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice. Pflügers Archiv - European Journal of Physiology, Vol. 459. 2010, pp. 969–976.
  Köhler R., Ruth P.
  (See online at https://doi.org/10.1007/s00424-010-0819-z)
• Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex. Cellular Physiology and Biochemistry, Vol.28. 2011, No. 1, pp. 77–86.
  Decher N., Wemhöner K., Rinné S., Netter M.F., Zuzarte M., Aller M.I., Kaufmann S.G., Li X.T., Meuth S.G., Daut J., Sachse F.B., Maier S.K.
  (See online at https://doi.org/10.1159/000331715)
• The pore structure and gating mechanism of K2P channels. EMBO Journal Vol. 30. 2011, Issue 21, pp. 3607-3619.
  Piechotta P.L., Rapedius M., Stansfeld P.J., Bollepalli M.K., Ehrlich G., Andres-Enguix I., Fritzenschaft H., Decher N., Sansom M.S., Tucker S.J., Baukrowitz T.
  (See online at https://doi.org/10.1038/emboj.2011.369)
• Dkk3 is a component of the genetic circuitry regulating aldosterone synthesis in the adrenal cortex. Human Molecular Genetics, Vol. 21. 2012, Issue 22, 15 pp. 4922–4929.
  El Wakil A., Bandulik S., Guy N., Bendahhou S., Zennaro M.C., Niehrs C., Mari B., Warth R., Barhanin J., Lalli E.
  (See online at https://doi.org/10.1093/hmg/dds333)
• Inherited long QT syndrome: clinical manifestation, genetic diagnostics, and therapy. Herzschrittmachertherapie & Elektrophysiologie, Vol. 23. 2012, pp. 211–219.
  Zumhagen S., Stallmeyer B., Friedrich C., Eckardt L., Seebohm G., Schulze-Bahr E.
  (See online at https://doi.org/10.1007/s00399-012-0232-8)
• State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. Channels, Vol. 6. 2012, Issue 6, pp. 473-478.
  Rapedius M., Schmidt M.R., Sharma C., Stansfeld P.J., Sansom M.S., Baukrowitz T., Tucker S.J.
  (See online at https://doi.org/10.4161/chan.22153)
• Alterations of N-3 Polyunsaturated Fatty Acid-Activated K2P Channels in Hypoxia-Induced Pulmonary Hypertension. Basic & clinical pharmacology & toxicology, Vol. 113. 2013, Issue 4, pp. 250-258.
  Nielsen G., Wandall-Frostholm C., Sadda V., Olivan-Viguera A., Lloyd E.E., Bryan R.M., Jr., Simonsen U., Kohler R.
  (See online at https://doi.org/10.1111/bcpt.12092)
• Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system. Endocrinology, Vol. 154. 2013, Issue 8, pp. 2712–2722.
  Bandulik S., Tauber P., Penton D., Schweda F., Tegtmeier I., Sterner C., Lalli E., Lesage F., Hartmann M., Barhanin J., Warth R.
  (See online at https://doi.org/10.1210/en.2013-1101)
• The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C. Cardiovascular Research, Vol. 97. 2013, Issue 1, pp. 97–105.
  Schiekel J., Lindner M., Hetzel A., Wemhöner K., Renigunta V., Schlichthörl G., Decher N., Oliver D., Daut J.
  (See online at https://doi.org/10.1093/cvr/cvs285)
• Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2. Pflügers Archiv - European Journal of Physiology, Vol. 466. 2014, pp. 1735–1745.
  Renigunta V., Zou X., Kling S., Schlichthörl G., Daut J.
  (See online at https://doi.org/10.1007/s00424-013-1404-z)
• Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors. Nature Communications, Vol. 5. 2014, Article number: 5540.
  Wilke B.U., Lindner M., Greifenberg L., Albus A., Kronimus Y., Bünemann M., Leitner M.G., Oliver D.
  (See online at https://doi.org/10.1038/ncomms6540)
• Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons. Journal of Physiology, Vol. 593. 2015, Issue 1, pp. 127-144.
  Bista P., Pawlowski M., Cerina M., Ehling P., Leist M., Meuth P., Aissaoui A., Borsotto M., Heurteaux C., Decher N., Pape H.C., Oliver D., Meuth S.G., Budde T.
  (See online at https://doi.org/10.1113/jphysiol.2014.276527)
• Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea? Pflügers Archiv - European Journal of Physiology, Vol. 467. 2015, pp. 1081–1090.
  Kiper A.K., Rinné S., Rolfes C., Ramirez D., Seebohm G., Netter M.F., Gonzalez W., Decher N.
  (See online at https://doi.org/10.1007/s00424-014-1665-1)
• TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes. Journal of Molecular and Cellular Cardiology, Vol. 81. 2015, pp. 71-80.
  Rinné S., Kiper A.K., Schlichthörl G., Dittmann S., Netter M.F., Limberg S.H., Silbernagel N., Zuzarte M., Moosdorf R., Wulf H., Schulze-Bahr E., Rolfes C., Decher N.
  (See online at https://doi.org/10.1016/j.yjmcc.2015.01.017)
• The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3. Pflügers Archiv - European Journal of Physiology, Vol. 467. 2015, pp. 1105–1120.
  Kilisch M., Lytovchenko O., Schwappach B., Renigunta V., Daut J.
  (See online at https://doi.org/10.1007/s00424-014-1672-2)
• The role of two-pore-domain background K⁺ (K₂p) channels in the thalamus. Pflügers Archiv - European Journal of Physiology, Vol. 467. 2015, Issue 5. pp. 895–905.
  Bista P., Cerina M., Ehling P., Leist M., Pape H.C., Meuth S.G., Budde T.
  (See online at https://doi.org/10.1007/s00424-014-1632-x)