Modulation of excitation/inhibition balance by NMDAR antagonism in depression (A06)

• Subject Area: Human Cognitive and Systems Neuroscience
• Term: from 2008 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 36555331

We will investigate the cellular mechanisms by which the NMDAR antagonist Ketamine changes the brains functional network. These therapeutically desired neuronal changes will then be investigated for their influence on negative attentional bias in depression prone individuals. This translation is reached by combined investigation of molecular and systems levels in analogous experiments in humans and mouse models.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 779: Neurobiology of Motivated Behaviour
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Co-Applicant Institution: Leibniz-Institut für Neurobiologie (LIN)
• Project Heads: Professor Dr. Bernhard Bogerts, until 12/2015; Professorin Dr. Anna Fejtová; Professor Dr. Martin Walter