Struktur und Dynamik der Protein-O-Mannosylierungsmaschinerie
(A18)
Fachliche Zuordnung
Zellbiologie
Förderung
Förderung von 2008 bis 2015
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5485988
Protein translocation in the endoplasmic reticulum (ER) and protein glycosylation are intimately connected, fundamental processes of eukaryotic cells. Nascent polypeptide chains are N-glycosylated and O-mannosylated while they are entering the ER. Translocation and N-glycosylation take place on a large molecular machine, the translocon complex (TC). In order to understand the molecular basis of coupling protein translocation and N-glycosylation with protein O-mannosylation we aim to analyze the molecular architecture of the O-mannosylation machinery and its macromolecular association with the TC complex.
DFG-Verfahren
Sonderforschungsbereiche
