In vitro Germ Cell Differentiation of Cord-Blood-derived Unrestricted Somatic Stem Cells (USSC)

• Applicant: Professor Dr. Hans Robert Schöler
• Subject Area: Hematology, Oncology
• Term: from 2007 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 20803802

Human cord-blood derived unrestricted somatic stem cells (USSC) can be reprogrammed to induced pluripotent stem (iPS) cells. This project derives and characterizes iPS cells from USSC (iP-USSC) by different means. The differentiation potential of reprogrammed cord blood cells will be assessed in comparison to native USSC. The focus of this project embraces mesodermal / hematopoietic and germ cell induction from iP-USSC. Besides reprogramming to full pluripotency induction of mesodermal progenitors in USSC will be evaluated.

• DFG Programme: Research Units
• Subproject of: FOR 717: Unrestricted Somatic Stem Cells from Umbilical Cord Blood (USSC)
• Participating Person: Professor Dr. Tobias Cantz