Circuit-specific improvements of mnemonic discrimination in the rodent and human entorhino-hippocampal subnetworks (B07*)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Human Cognitive and Systems Neuroscience
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 425899996

We hypothesize that the neural resources for spatial and non-spatial memory can be selectively mobilised in a network-specific manner. Our research strategy consists in targeting distinct entorhino-hippocampal subnetworks, deploying exogenous (Deep Brain Stimulation, optogenetics) and endogenous stimulation (cognitive training) using a cross-species approach and, characterising at the single-cell and whole-brain levels the physiological mechanisms underlying this mobilisation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1436: Neural resources of cognition
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professor Dr. Frank Angenstein; Davide Ciliberti, Ph.D.; Professorin Dr. Magdalena Sauvage