Project Details
Projekt
Metabolic networks supporting FSP1 function and their relevance in ferroptotic cell death
Subject Area
Cell Biology
Biochemistry
Biochemistry
Term
since 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 550345857
The pathway of ferroptosis, triggered by the buildup of (per)oxidized phospholipids, is important in various health and disease states such as aging, neurodegenerative disorders, and ischemia/reperfusion injuries. Although this metabolic pathway holds great promise for the treatment of challenging diseases such as neuroblastoma, its therapeutic potential remains limited due to an incomplete understanding of the underlying regulating processes. Our project aims to fill this knowledge gap by focusing on identifying and characterizing the factors that regulate ferroptosis through yet-unrecognized mechanisms. Building on the groundbreaking research results of the first funding phase, which emphasized the central anti-ferroptotic role of ferroptosis suppressor protein 1 (FSP1), our project has two main objectives. In work package 1, we will explore and characterize novel pathways that influence the stability of FSP1. In aim 2, our focus shifts towards understanding the relevance of FSP1 in in vivo models, delineating its function under conditions that induce ferroptosis or oncogenic stress. Ultimately, these endeavors should pave the way for a deeper understanding of the factors that modulate ferroptosis susceptibility and could ultimately open a new chapter in our knowledge on the contribution of uncontrolled phospholipid peroxidation in disease settings.
DFG Programme
Priority Programmes
