Multiscale imaging of mechanisms underlying mast cell-dependent inflammation (C08*)

• Subject Area: Immunology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

Mast cells play pivotal roles in local and systemic forms of anaphylactic inflammation. Employing multifaceted imaging methodology, our study aims at (1) understanding the intracellular interplay of organelle systems upon mast cell activation, (2) investigating how mast cell-activating triggers disseminate inflammatory signal through the tissue, and (3) developing methodology to assess systemic anaphylactic reactions with whole body imaging.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Tim Lämmermann, Ph.D.; Dr. Angelika Rambold