SFB 592:
Signaling Mechanisms in Embryogenesis and Organogenesis
Subject Area
Biology
Agriculture, Forestry and Veterinary Medicine
Medicine
Term
from 2001 to 2012
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5484803
The collaborative research centre 592 investigates basic mechanisms involved in embryonic pattern formation as well as differentiation and morphogenesis during organogenesis. Both animal and plant systems are analyzed in parallel, as basic aspects of signaling mechanisms, like the formation of signal sources, the control of the range of signaling, or the signal transduction mechanisms are common to many systems.
Research area A "Signaling Mechanisms" investigates the formation of signaling molecules, the establishment of local sources, as well as the influence of signals on cell behavior and cell differentiation. Among the projects, one focus is on integration of different signaling pathways to achieve developmental decisions. Among the signaling molecules investigated are Wnt, Delta/Notch, FGFs, TGFs, Hedgehog, Phytochrome, Calcium and Auxin. Research area B "Cell Polarity" investigates the polarization of cells and tissues as a basis for developmental decisions (organ differentiation, formation of signaling sources). Aspects as diverse as polar signal transport, polar signal transduction, and epithelio-mesenchymal transitions are studied. In some projects, biomedically relevant questions concerning the role of polar epithelia and polar signaling during organogenesis are investigated. The centre also operates a central unit "In vivo imaging for visualization of signaling and regulatory processes", which provides and optimizes methods for visualization of signaling pathway components and activity states in living embryos. One goal is to visualize signaling mechanisms during embryogenesis in real-time.
DFG Programme
Collaborative Research Centres
International Connection
Israel
Completed projects
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A01 - Signaling mechanisms in somite cell specification
(Project Head
Scaal, Martin
)
-
A2 - Signalmechanismen bei der Segmentierung von Wirbeltieren
(Project Head
Herrmann, Bernhard G.
)
-
A03 - Establishment of signaling centers, pattern formation, and control of differentiation in the zebrafish gastrula: roles of Pou5fl
(Project Heads
Driever, Wolfgang
;
Onichtchouk, Daria
)
-
A04 - Umsetzung von TGF-ß Signalen bei der embryonalen Musterbildung und Differenzierung
(Project Head
Meyer, Dirk
)
-
A5 - Die Rolle von Hedgehog in der Adenohypophysenentwicklung und der Ausbildung asonaler Bahnen im Gehirn des Zebrafischs
(Project Head
Varga, Zoltán Marton
)
-
A7 - Signal induzierte Symmetrie-Etablierung in der frühen Embryogenese bei Pflanzen
(Project Head
Neuhaus, Gunther
)
-
A08 - Photomorphogenesis in plants: spatial and temporal patterns of phytochrome-mediated signal transduction
(Project Heads
Kircher, Stefan
;
Nagy, Ph.D., Ferenc
;
Schäfer, Eberhard
)
-
A10 - Stem cell regulation in Arabidopsis plant apical meristems
(Project Head
Laux, Thomas
)
-
A11 - Festlegung der Position von Organen in Arabidopsis thaliana
(Project Head
Laux, Thomas
)
-
A12 - Molekulare Funktionen des FGF Signalwegs bei der Entwicklung des Wirbeltiergesichts
(Project Head
Neubüser, Annette
)
-
A14 - Signalling pathways required for propagation and differentiation of thymic epithelial progenitor cells
(Project Head
Boehm, Thomas
)
-
A16 - Genetische Analyse der Hypophysen-Entwicklung im Zebrafisch
(Project Head
Hammerschmidt, Matthias
)
-
A19 - ceh-16/engrailed kompartimentiert die Epidermis des Fadenwurms Caenorhabditis elegans
(Project Head
Baumeister, Ralf
)
-
A20 - Reelin signaling in the development of layers in the neocortex
(Project Head
Frotscher, Michael
)
-
A21 - Regulation of neural stem cell maintenance and fate choice in the vertebrate brain through novel aspects of Notch signaling
(Project Head
Taylor, Ph.D., Verdon
)
-
A22 - TGF-ß/GDNF-mediated crosstalk during sympathetic neuron development
(Project Head
Krieglstein, Kerstin
)
-
A23 - Specification and maintenance of chromaffin cells and their preganglionic innervation
(Project Heads
Kalcheim, Ph.D., Chaya
;
Unsicker, Klaus
)
-
B01 - In vivo Analyse von Protocadherin-ß Genen
(Project Head
Kemler, Rolf
)
-
B04 - Epithelio-mesenchymale Transitionen während der Entwicklung des paraxialen und intermediären Mesoderms
(Project Head
Brand-Saberi, Beate
)
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B5 - Kontrolle der späten Lungendifferenzierung in der Maus
(Project Head
Sippel, Albrecht E.
)
-
B6 - Elucidating novel mechanisms of focal adhesion signaling by targeted disruption of the mouse nephrocystin gene (Kurztitel: Nephrocystin signaling)
(Project Head
Hildebrandt, Friedhelm
)
-
B07 - The role of planar cell polarity proteins in renal development
(Project Head
Walz, Gerd
)
-
B08 - Regulation of lateral root development in Arabidopsis thaliana
(Project Head
Palme, Klaus
)
-
B09 - The role of nephrocystin-3 for celia-mediated signaling and determination of left/right asymmetry
(Project Head
Omran, Heymut
)
-
B10 - Development of the Glomerular Filter
(Project Heads
Huber, Tobias B.
;
Kramer-Zucker, Albrecht
)
-
C01 - Wnt-dependent and Wnt-independent Regulation of Organogenesis by LEF1
(Project Head
Grosschedl, Rudolf
)
-
C02 - Control of adipogenesis by the signal-regulated INHAT-repressor NIR
(Project Head
Schüle, Roland
)
-
C03 - Notch signalling in hematopoiesis: The role of RBP-Jk-assosiated transcriptional cofactors in lymphopoiesis
(Project Head
Borggrefe, Tilman
)
-
C05 - Protein interactions and modifications determine the activity of a major regulator of neural transcription, the POU protein UNC-86
(Project Head
Baumeister, Ralf
)
-
N02 - N02: Developmental biology involving mechanisms of pattern formation, signaling and differentiation in embryogenesis and organogenesis of animal or plant models
(Project Head
Pyrowolakis, Giorgos
)
-
Z01 - Central tasks of the Collaborative Research Centre
(Project Head
Driever, Wolfgang
)
-
Z02 - Central facility - In vivo Imaging (Life Imaging Center)
(Project Heads
Driever, Wolfgang
;
Nitschke, Roland
)
