Project Details
Projekt
FOR 585: Pathogen Specific Defense Mechanisms in the Mammary Gland
Subject Area
Agriculture, Forestry and Veterinary Medicine
Medicine
Medicine
Term
from 2005 to 2013
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5471805
Prevention and cure of infections of the mammary gland are significant goals for human medicine but also for veterinary medicine and animal housing. Using the cow as an example, the programme analyses relevant defence mechanisms in the mammary gland, but also mechanisms and genes contributing to the species-specific virulence of significant mastitis pathogens.
A central goal is the establishment of a comprehensive catalogue of mastitis relevant genes from the cow and, moreover, to uncover the interplay of gene products establishing the defence mechanisms in the mammary gland. In addition, molecular patterns of the pathogens will systematically and comparatively be analysed to gain insights into conserved and divergent infection strategies of pathogens. This will be supported by analyses into the molecular principles under covering divergent host tropisms of various strains of the same pathogen species. The understanding of molecular principles of both, infection and initial defence strategies inside the mammary gland will form the basis to define new parameters for the trait udder health . It is a long-term goal to identify and functionally validate new candidate genes, which may be used to breed for cows with improved immune protection of the mammary gland. Moreover, the understanding of the initial immune mechanisms inside the mammary gland might provide new strategies for mastitis prevention, based on a prophylactic modulation of the proprietary immune protection of the host and to develop new approaches for diagnosis and therapy mastitis.
A central goal is the establishment of a comprehensive catalogue of mastitis relevant genes from the cow and, moreover, to uncover the interplay of gene products establishing the defence mechanisms in the mammary gland. In addition, molecular patterns of the pathogens will systematically and comparatively be analysed to gain insights into conserved and divergent infection strategies of pathogens. This will be supported by analyses into the molecular principles under covering divergent host tropisms of various strains of the same pathogen species. The understanding of molecular principles of both, infection and initial defence strategies inside the mammary gland will form the basis to define new parameters for the trait udder health . It is a long-term goal to identify and functionally validate new candidate genes, which may be used to breed for cows with improved immune protection of the mammary gland. Moreover, the understanding of the initial immune mechanisms inside the mammary gland might provide new strategies for mastitis prevention, based on a prophylactic modulation of the proprietary immune protection of the host and to develop new approaches for diagnosis and therapy mastitis.
DFG Programme
Research Units
Projects
- Differentielle Proteom-Analyse Mastitis-infizierter Zellen und Gewebe (Applicant Arnold, Georg Josef )
- In vivo-Studien beim Rind zur Pathogen-spezifischen Immunantwort auf Toxine verschiedener Mastitiserreger (Applicant Bruckmaier, Rupert M. )
- Mastitismodell zur Analyse des initialen Erreger-Wirtskontaktes im distalen Milchdrüsenkompartiment (Applicant Zerbe, Holm )
- Pathogen-spezifische Signaltransduktion in der Milchdrüsen Epithel Zelle (Applicant Seyfert, Hans-Martin )
- Physiologische Proteomanalyse des Erregers bei S.aureus induzierter Mastitis (Applicant Engelmann, Susanne )
- Struktur/Wirkungsbeziehungen von Immunstimuli aus bakteriellen Mastitis-Erregern (Applicant von Aulock, Sonja )
- Strukturen immunmodulierender Substanzen der Mastitiserreger Escherichia coli und Staphylococcus aureus (Applicant Holst, Otto )
- Suche nach Mastitis-relevanten Genen in der Milchdrüse des Rindes (Applicant Blum, Helmut )
Spokesperson
Professor Dr. Hans-Martin Seyfert
