SPP 1088:  Age-Related Macular Degeneration

• Subject Area: Medicine
• Term: from 2000 to 2006
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5470091

No abstract available

• DFG Programme: Priority Programmes
• International Connection: Switzerland

Projects

• Age-related macular degeneration: Regulative mechanisms of cell death and survival; effects of hypoxia (Applicant Remé, Charlotte )
• Age-related macular degeneration: signal transduction leading to changed secretion of angiogenic factors by retinal pigment epithelial cells from excised neovascular membranes (Applicant Strauß, Olaf )
• Application and further development of fixation-controlled tests of macular function in AMD (Applicant Zrenner, Eberhart )
• Autologe Translokation von Irispigmentepithel auf resorbierbaren Unterlagen als neue therapeutische Methode bei altersbedingter Makuladegeneration (Autologous iris pigment epithelium (IPE) translocation on biodegradable supports as new therapeutic modality to treat age-related macular degeneration) (Applicant Klee, Doris )
• Autologe Translokation von Irispigmentepithel auf resorbierbaren Unterlagen als neue therapeutische Methode bei altersbedingter Makuladegeneration (Autologous iris pigment epithelium (IPE) translocation on biodegradable supports as new therapeutic modality to treat age-related macular degeneration) (Applicant Wiedemann, Peter )
• Autologe Translokation von Irispigmentepithel auf resorbierbaren Unterlagen als neue therapeutische Methode bei altersbedingter Makuladegeneration (Autologous iris pigment epithelium (IPE) translocation on biodegradable supports as new therapeutic modality to treat age-related macular degeneration) (Applicant Kirchhof, Bernd )
• Biometrical support and information infrastructure for the Priority Research Program "Age-related Macular Degeneration; biometrics, data management, and monitoring of the clinical study "MARAN - Surgical Management of Subfoveal Choroideal Membranes in AMD by Macular Translocation" (Applicant Mansmann, Ulrich )
• Characterization of novel genes expressed in the retinal pigment epithelium (RPE) and assessment of their role in age-related macular degeneration (Applicant Weber, Bernhard H.F. )
• Effects of lipofuscin accumulation on lysosomal functions of human RPE cells (Applicant Kopitz, Jürgen )
• Expression von Vascular Endothelial Growth Factor (VEGF) in retinalem Pigmentepithel bei altersabhängiger Makuladegeneration (Expression of angiogenic factors and their regulation in human retinal pigment epithelium of patients with age-related macular degeneration) (Applicant Hansen, Lutz Lothar )
• Fundus Autofluorescence imaging in Age-related Macular degeneration (FAM-Study) using confocal scanning laser ophthalmoscopy (Applicant Holz, Frank G. )
• Fundus Autofluorescence imaging in Age-related Macular degeneration (FAM-Study) using confocal scanning laser ophthalmoscopy (Applicant Foja, Christian )
• Genetics of macular drusen formation in rhesus macaques - Genetik makulärer Drusen beim Rhesusaffen (Applicant Schmidtke, Jörg )
• Identifizierung von Kandidaten-Genen altersabhängiger Makuladegeneration (AMD) und familiärer Formen von Netzhauterkrankungen (Identification of candidate genes for age-related macular degeneration (AMD) and familial forms of retinal dystrophies) (Applicant Berger, Wolfgang )
• Influence of inflammatory mediators on RPE barrier function and choroidal neovascularization (Applicant Joussen, Antonia )
• Longitudinales Monitoring der Netzhautfunktion bei altersabhängigen Veränderungen der Makula unter Berücksichtigung des Spontanverlaufes und von therapeutischen Eingriffen (Multifocal electroretinography in age-related macular degeneration: Monitoring of retinal function in various stages of the di (Applicant Jurklies, Bernhard )
• Optimizing photodynamic therapy in the treatment of age-related Macular Degeneration (Applicant Schmidt-Erfurth, Ursula )
• Pathomechanisms of choroidal neovascularisation and oxidative stress (Applicant Wiedemann, Peter )
• Pathophysiologie und Topographie von Schadensmechanismen in AMD-relevanten Tiermodellen (Pathophysiology and topographical distribution of disease mechanisms in animal models relevant for AMD) (Applicant Seeliger, Mathias )
• Prospective sibling study for clinical and genetic characterisation of early stages of age-related macular degeneration (Applicant Kellner, Ulrich )
• Prospective study to identify prognostic factors for the progression of age-related maculopathy (Applicant Hense, Hans-Werner )
• Role of macular pigment density in the pathophysiology, clinical outcome and therapy of age-related maculopathy (Applicant Wolf, Sebastian )
• Symposia, workshops, and sabbaticals of the Priority Program "Age-Related Macular Degeneration (Applicant Kirchhof, Bernd )
• Symposia, workshops, and sabbaticals of the Priority Program "Age-Related Macular Degeneration" (Applicant Holz, Frank G. )
• The influence of the protease inhibitor cystatin C on the occurrence of age-related macular degeneratin: evaluation of secretion by RPE cells and of possible mechanisms for its inhibition (Applicant Richard, Gisbert )
• The role of DNA sequence variants in AMD: Identification and molecular genetic analysis of candidate genes (Applicant Gal, Andreas )
• The role of the RPE baasement membrane in the pathogenesis of AMD (Applicant Pauleikhoff, Daniel )

• Spokesperson: Professor Dr. Bernd Kirchhof
• Deputy: Professor Dr. Frank G. Holz