FOR 434:
Oligosaccharide and DNA Chips - Recognition of Secondary Gene Products
Subject Area
Chemistry
Medicine
Term
from 2001 to 2007
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5468316
The availability of genomic information for entire organisms presents chemists and biologists with new opportunities, but also with new challenges. The traditional single experiment approach does not allow mining the biological information to the extent desirable. Instead, massively parallel experiments have to be developed. Biochips are arguably the most important tool in the rapidly growing repertoire ofgenomic scientists, since they allow performing molecular recognitionexperiments with thousands of biological target structures. The research unit "Oligosaccharide and DNA Chips - Recognition of Secondary Gene Products" focuses on developing new types of biochips, improving the selectivity of known types of biochips, and establishing new biomolecular recognition phenomena that may later be employed in novel biochips. Organic synthesis, biophysical characterization, and testing of biological activities are core techniques. Among the compounds to be immobilized on chip surfaces are oligosaccharides and oligonucleotides. The principles of molecular recognition are studied for antigens, lipoteichoic acids, and membrane-bound oligosaccharides. The research unit employs aninterdisciplinary, four-pronged approach based on organic synthesis,structure elucidation, biological testing, and physical measurements in solutions and on surfaces.
DFG Programme
Research Units
Projects
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Arbeitsgruppe "Professor Geyer"
(Applicant
Geyer, Armin
)
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Arbeitsgruppe "Professor Schmidt"
(Applicant
Schmidt, Richard R.
)
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Die Rolle von Glycolipidclustern bei der Zelladhäsion: Kooperative molekulare Erkennung membranständiger Kohlenhydrate Teilprojekt 7 A: Arbeitsgruppe "Dr. Geyer"
(Applicant
Geyer, Armin
)
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Die Rolle von Glycolipidclustern bei der Zelladhäsion: Kooperative molekulare Erkennung membranständiger Kohlenhydrate Teilprojekt 7 B: Arbeitsgruppe "Professor Schmidt"
(Applicant
Schmidt, Richard R.
)
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Effiziente und Selektive Erkennung von DNA auf Oberflächen
(Applicant
Richert, Clemens
)
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Funktionale Nucleinsäure-Sonden zur Untersuchung sequenzunabhängiger Protein-DNA-Wechselwirkungen
(Applicant
Marx, Andreas
)
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Highly efficient photolabile protecting groups for photolithigraphic synthesis of DNA chips
(Applicant
Steiner, Ulrich
)
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Kohlenhydrat Erkennungsstrukturen von Lectin-Bindungsdomänen des Tumor-Nekrosefaktor-alpha
(Applicant
Przybylski, Ph.D., Michael
)
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Molekulare Erkennungsstrukturen von Kryoglobulin-Antigenen
(Applicant
Przybylski, Ph.D., Michael
)
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Multivalente Erkennung und Differenzierung von Galactose bindenden Lectinen durch oberflächengebundene Neoglycopeptide
(Applicant
Wittmann, Valentin
)
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Oligosaccharid- und DNA-Chips-Analyse sekundärer Genprodukte
(Applicant
Marx, Andreas
)
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Spezifische Interaktionen von Poly(ADP-Ribose) definierter Komplexität mit Bindeproteinen (Arbeitsgruppe Bürkle)
(Applicant
Bürkle, Alexander
)
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Spezifische Interaktionen von Poly(ADP-Ribose) definierter Komplexität mit Bindeproteinen (Arbeitsgruppe Marx)
(Applicant
Marx, Andreas
)
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Struktur/Wirkungsbeziehungen bei der Erkennung Gram-positiver Bakterien-Zellwandbestandteile durch das Immunsystem Teilprojekt 6 A: Arbeitsgruppe "Professor Hartung"
(Applicant
Hartung, Ph.D., Thomas
)
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Strukturaufklärung, Synthese und immunanalytische Charakterisierung immunstimulierender und antigener Komponenten von Chlamydophila pneumoniae
(Applicant
Hermann, Corinna
)
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Synthese und kovalente Anbindung von Oligosacchariden an Glasoberflächen - Erzeugung von Oligosaccharid-Chips
(Applicant
Schmidt, Richard R.
)